Disorders of Vulva & Vagina Flashcards
External vulvar anatomy
- boundaries
- structures included
- Boundaries extend from mons pubis to anus to labial cural folds
- Structures include: Labia majora, labia minora, paired Bartholin’s glands, Skene’s glands, urethra, anus, clitoris
Lymphatic drainage of vulva
- Lymphatics of vulva drain from posterior to anterior traversing thru the mons pubis and into superficial and deep inguinal nodes
- Tend to drain to ipsilateral side
What is the function of bartholin glands?
Secrete mucus for lubrication
What are the 3 tissue types and locations that make up bartholin glands?
- Proximal = glandular epithelium
- Distal = transitional epithelium
- Opening = squamous epithelium
What causes a bartholin gland cyst?
Orifice of gland may become obstructed leading to mucus accumulation and cystic dilatation.
Characteristics of bartholin gland cyst
- unilateral
- soft, painless mass
Which population should always have an excision of a bartholin gland cyst?
women over 40 to exclude carcinoma
How is a bartholin abscess different from a bartholin gland cyst?
-the cyst is now infected
Characteristics of bartholin gland abscess
- very painful
- fluctuant, swollen, red, warm, mass
Tx of bartholin gland abscess
I&D with culture, consider drain placement (Word catheter)
What is a word catheter?
- catheter that is placed into the area of the now empty abscess
- it is inflated and left in place for 4-6 weeks
- this promotes the formation of an epithelialized tract for drainage
Marsupialization of Bartholin Gland Abscess
- Abscess cavity is incised 1-2 cm in length and drained
- The edge of the cyst wall is grasped and everted open
- The opening is then sutured open creating a new larger duct for drainage
List the non-neoplatic disorders (4)
- Lichen Sclerosis
- Lichen Simplex Chronicus/Squamous Cell Hyperplasia
- Lichen Planus
- Vulvar Psoriasis
What is the most common vulvar derm disorder?
Lichen sclerosis
Etiology of lichen sclerosis
- Chronic, relapsing and remitting disorder (inflammatory)
- Peak Onset: Pre-pubertal and postmenopausal women
Appearance/sx of lichen sclerosis
- *Figure 8/hourglass appearance**
- Lesions appear as smooth, white plaques.
- Surface is smoothed and resembles parchment or wrinkled cigarette paper.
- Sx: intense pruritis, pain, dyspareunia
Etiology and anatomy of lichen sclerosis
Etiology is unknown:
- Autoimmune
- Genetic
- Hormonal
- labia minora, labia majora, clitoris, and perineum can all be involved
- vagina is spared
Dx/Tx of lichen sclerosis
Diagnosis made by punch biopsy.
-Repeat biopsy if new lesions/symptoms as these patients are at increased risk for vulvar cancer.
Treatment:
- Patient education
- Topical corticosteroids
- -Applied BID/daily until symptoms are controlled.
- -Then 1-3 x weekly for maintenance.
List the drugs for tx of lichen sclerosis
- Topical tacrolimus (Protopic 0.03 or 0.1%) or pimecrolimus (Elidel 1%) demonstrated effective but mainly use with taper.
- Recalcitrant: oral hydroxychloroquine or cyclosporin
Etiology of Lichen Simplex Chronicus
- AKA squamous cell hyperplasia – NOT a malignant precursor**
- Secondary to chronic rubbing/scratching.
- Associated with pruritis
- Mostly in premenopausal women
- Typically found on hair-bearing areas of labia majora
Describe clinical findings of lichen simplex chronicus
- Characterized by benign epithelial thickening and hyperkeratosis from chronic irritation
- Skin is thick with exaggerated skin markings
- Usually bilateral and symmetric
- *not a distinct entity but rather a description of morphologic alterations of vulva.
Dx/Tx of lichen simplex chronicus
Diagnosis is again made by biopsy.
Treatment:
- Patient education
- Identify and treat cause of itching (infection, contact dermatitis, etc.)
- Topical corticosteroids
Etiology of Lichen Planus
- Rare disorder believed to be autoimmune.
- Affects skin and mucous membranes
- Commonly affects the groin and the mouth**
- Leads to intense pruritus, burning, dysuria, dyspareunia, and post coital bleeding
- Mostly affects postmenopausal women
- Almost 70% of patients have vaginal involvement
What is lichen planus characterized by??
Lesions characterized by bright erythematous erosions with white striae or white border (Wickham’s striae) visible along the margins
Complications of lichen planus
- Recurrent exacerbations, slow healing and scarring are common
- Scarring can cause significant anatomic disruption, stenosis of vaginal opening and urethral opening
Tx of lichen planus
Can be difficult to treat:
- Topical corticosteroids
- Oral corticosteroids
- Vaginal dilators
- Recalcitrant : hydroxychloroquine, thalidomide, apremilast (Otezla), cyclosporine, methotrexate, mycophenolate mofetil
There is no role for surgery
Etiology of vulvar psoriasis
- Systemic skin disease characterized by silver-white scales.
- Vulvar lesions sharply demarcated erythematous absent of the silver-white scale.
- Moist and shiny
- Can affect elbows, knees, back, scalp, and vulva.
- It can be located just in one area, but it’s likely to be elsewhere on the body.
- Associated with pruritis.
What is koebner phenomenon in regards to vulvar psoriasis?
Koebner phenomenon – skin lesions on lines of trauma
Dx/Tx of vulvar psoriasis
Diagnosis is made by vulvar biopsy.
Treatment includes:
- Topical high potency steroids followed by maintenance therapy with lower potency steroids.
- Tar creams
List the vulvar neoplasms (5)
- Extramammary Paget Disease
- Vulvar Intraepithelial Neoplasia (VIN)
- Vulvar carcinoma
- Bartholin gland carcinoma
- Vulvar melanoma
Etiology of Extramammary Paget Disease
- Generally benign condition.
- Pruritic, erythematous, with well-demarcated eczematoid appearance.
- MC in postmenopausal, Caucasian women, 60s and 70s.
What nonvulvar locations will women have carcinoma in with extramammary paget disease?
- Breast
- Colon
- Urethra
- Bladder
Tx of extramammary paget disease
Treatment includes:
- Patient education
- Wide local excision
- Chemotherapy – 5-FU, imiquimod
- -These are typically used for widespread skin cancers: help to attract the bodies own immune system.
- Microscopically positive margins are common.
- Recurrence is common – 30-60%, 8-26% with MOHS.
What is vulvar intraepithelial neoplasia (VIN)?
- Precancerous/dysplastic lesion.
- Spectrum of disease ranging from mild dysplasia to vulvar carcinoma in-situ
Describe the lesions in vulvar intraepithelial neoplasia (VIN)
- Lesion appearance is highly variable but usually sharply demarcated.
- May be white, hyperkeratotic plaques, hyperpigmented lesions or areas of erythema
Patient presentation with VIN
Patients may be asymptomatic or have pruritus, bleeding, or pain.
Etiology and risk factors of VIN
- Incidence is increasing - particularly in younger women (related to HPV)
- Bimodal distribution of patients:
- -Younger, premenopausal women
- -Postmenopausal women
Risk Factors:
- HPV infection (90%)
- Smoking
- Immunodeficiency (HIV)
What is the importance of the “grades” of VIN?
- The degree of dysplasia has to do with the depth into the epidermis/dermis.
- Remember: carcinoma in-situ is full-thickness of the epidermis.