Statistics Flashcards

1
Q

What indicates if a test is reliable?

A

If it is repeated again and again and gets the same result

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2
Q

What does it mean if a test is valid?

A

If it meets the requirements of the scientific study

e.g. randomisation, blinding

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3
Q

What type of data is nominal?

A

categorical, with no ranking

e.g. gender, blood group

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4
Q

What type of data is ordinal?

A

categorical with ranking

e.g. preference scale

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5
Q

what type of data is discrete?

A

numerical data which is in whole numbers

e.g. number of people

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6
Q

What is the variance of a sample? How is it calculated?

A

A measure of dispersion of sample

Average of squared differences from the mean

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7
Q

What is the relationship between variance and SD?

A

SD = square root of variance

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8
Q

What assumptions must be made with parametric data?

A

Continuous data

Population data is normally distributed

Sample and source population have same SD/variance e.g. spread

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9
Q

When are non-parametric tests more appropriate than parametric?

A

When data is not continuous (e.g. ordinal, nominal)

When distribution of population is not known

Small sample size -> less affected by outliers, uses median rather than mean. RANKS data

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10
Q

What is the central limit theorem?

A

In a skewed population, sample becomes more “normal” in shape as n increases

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11
Q

What is the parametric test used to compare 2 independant groups?

What is the non-parametric equivalent?

A

T-test

Wilcoxon rank sum test

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12
Q

What is the parametric test used to compare paired observations?

What is the non-parametric equivalent?

A

T-test for paired

Wilcoxon signed rank test

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13
Q

What is the parametric test used to compare several groups?

What is the non-parametric equivalent?

A

ANOVA

Kruskal Wallis test

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14
Q

What is the parametric test used to find linear relationship between 2 variables e.g. BP and sleep duration?

What is the non-parametric equivalent?

A

Pearson’s correlation

Spearman’s Rank correlation

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15
Q

What is the non-parametric test used to test association between 2 qualitative variables e.g. gender, smoking status?

Which one for sample size
>50?
<50?

A

Chi squared

> 50 -> chi squared

<50 -> Fisher’s exact

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16
Q

What is the difference between t-statistic and z-statistic?

A

T = sample with unknown SD

Z = known SD

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17
Q

What is a Type 1 error?

How is it minimised?

A

False positive

i.e. wrongly rejecting null hypothesis
Avoid by setting p-value low enough

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18
Q

What is a Type 2 error?

How is it minimised?

A

False negative

i.e. wrongly accepting null hypothesis
Avoid by having enough POWER

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19
Q

What is “power” of a study?

i.e. what does 80% power in a study mean?

A

The ability of a study to demonstrate a statistically significant association

80% power = study has 80% chance of ending with a p-value <0.05

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20
Q

What is “power” of a study?

i.e. what does 80% power in a study mean?

A

The ability of a study to demonstrate a statistically significant association

80% power = study has 80% chance of ending with a p-value <0.05

21
Q

What would changing your p-value cut-off from 0.05 to 0.01 do to the power of a study?

A

Decrease it

Smaller p-value requires more power

22
Q

How can power be increased in a study design?

A

Increase sample size

Increase p-value

Increase effect size

23
Q

What does a 95% confidence interval indicate?

A

we are 95% confident that true population mean occurs within this interval

24
Q

What error is more likely with post-hoc analyses?

A

Type 1 error

25
What is the familywise error rate? What is the Bonferroni correction?
Cumulative Type 1 error e.g. if testing 3 hypotheses, need to calculate 0.95 x 0.95 x 0.95 Bonferroni correction compensates for this by fixing p-value across tests
26
WHich of these measures is not affected by prevalence of an event? ARR NNT RR
RR
27
What is the difference between odds of an event and probability of an event?
Odds = no. of events / no. of NON-events Probability = no. of events / TOTAL events
28
What is the log rank test used for?
To compare 2 survival curves
29
Which study design is best for rare disease? Which study design is best for rare exposures?
Rare disease - case-control Rare exposure - cohort
30
What is the rationale for randomisation in RCTs?
To reduce confounding | Reduces selection bias
31
What is the rationale for blinding?
To reduce information (observe) bias
32
What kind of bias does non-random sampling lead to?
Selection bias
33
What kind of bias can occur if investigators know which intervention the next participant will receive
Allocation / channelling bias
34
What is ascertainment bias?
When data is collected in a way such that some members of population are less likely to be included e.g. requiring a doctor's visit to get Alzheimer's diagnosis
35
What is information bias?
Systematic difference in way information is collected / recorded
36
Which types of studies are liable to recall bias?
Where self-reporting occurs e.g. case control
37
What is the Hawthorne effect?
Participants report improvement if they know they are on the drug/being observed
38
what is the Halo effect?
error in reasoning where impression is formed due to a single trait
39
What are trials of nutrition or exercise liable to (with bias)?
Performance bias may inflate estimated effect of intervention, with subjective outcomes
40
What is length time bias?
Diseases with long duration are more likely to be included in screening, and are less aggressive e.g. slower-growing cancers are picked up on screening and tend towards better prognosis
41
What is lead time bias?
Occurs when a disease is diagnosed earlier, but it actually has no impact on outcome of disease. However it appears like there is prolonged survival
42
What is the aim of intention to treat analysis?
To minimise selection bias Under-estimates effect
43
What is another name for True positive rate?
Sensitivity
44
What is another name for True negative rate?
Specificity
45
Which of these are affected by prevalence of disease? Sens Spec NPV PPV
NPV -> increasing prevalence decreases NPV PPV -> increasing prevalence increases PPV
46
What is the purpose of Phase 1 trials?
Focus on pharmacology - in small number of healthy subjects - dose-finding, dosing schedule
47
What is the purpose of Phase 2 trials?
Focus on safety | - usually in subjects with disease, but small number
48
What is the purpose of Phase 3 trials?
Focus on efficacy | - large numbers of patients with disease
49
What is the purpose of Phase 4 trials?
Focus on long-term effects | - post-marketing