Antibodies Flashcards

1
Q

Anti dsDNA

A

SLE - specific

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2
Q

Anti Yo

A

Paraneoplastic encephalitis with breast/ovarian cancer

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3
Q

Anti NMDA

A

Paraneoplastic encephalitis with ovarian teratoma

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4
Q

AQP4 ab or MOG ab

A

NMOSD

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5
Q

Sjogren’s

A

Anti Ro

Anti La

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6
Q

Anti U1RNP

A

Mixed CTD

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7
Q

Anti mitochondrial

A

Primary biliary cirrhosis

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8
Q

Anti Smooth Muscle

A

Autoimmune Hepatitis

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9
Q

Anti Ma / Ta

A

Paraneoplastic encephalitis with testicular cancer

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10
Q

Anti Scl70

A

Diffuse systemic sclerosis - a/w ILD

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11
Q

Anti MuSK

A

Myasthenia Gravis - less ocular manifestations

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12
Q

Anti Mi2

A

Dermatomyositis with skin lesions

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13
Q

Anti THSD7A Ab

A

Membranous GN

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14
Q

Anti VGCC

A

Lambert-Eaton Myasthenic Syndrome

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15
Q

Anti-cardiolipin

A

APLS

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16
Q

Neonatal Lupus

A

Anti-Ro

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17
Q

Anti centromere

A

Limited systemic sclerosis, a/w with Pulmonary HTN

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18
Q

Anti CCP

A

RA

19
Q

Anti histone

A

Drug-induced lupus

20
Q

Anti Sm

A

SLE - Highly specific

21
Q

Anti Hu

A

Paraneoplastic encephalitis with SCLC

22
Q

Anti PLAR2

A

Membranous GN

23
Q

Anti Jo1

A

Anti-synthetase syndrome

24
Q

Anti ribosomal P

A

SLE with neuropsychiatric manifestations

25
Q

Anti Ri

A

Paraneoplastic encephalitis with SCLC

26
Q

Anti LKM1

A

Autoimmune hepatitis Type 2

27
Q

Anti KELCH-11

A

Paraneoplastic encephalitis with testicular seminoma

28
Q

Anti-TIF1 gamma

A

Dermatomyositis - a/w malignancy

29
Q

RNA polymerase

A

Diffuse Systemic Sclerosis - a/w renal manifestations

30
Q

Anti-NXP2

A

Dermatomyositis - a/w malignancies

31
Q

Anti-SRP

A

Necrotising Autoimmune Myositis

32
Q

Anti-HMGCoA reductase

A

Necrotising Autoimmune Myositis

33
Q

Anti cN1A

A

Inclusion body myositis

34
Q

Anti MDA-5

A

Dermatomyositis - a/w ILD

35
Q

CD5 + CD19 expression

A

CLL

36
Q

Reed Sternberg cells

Which CD markers?

A

Hodgkin’s lymphoma

CD 15 / 30

37
Q

Plasma cells

A

CD38

38
Q

Stem cells

A

CD34

39
Q

Del 5q in what condition?

A

MDS

Treat with lenolidamide

40
Q

3 poor prognostic cytogenetic mutations in CLL?

A

Del 17p
Unmutated IGHV
tp53

41
Q

t(14, 18) -> what lymphoma?

A

Follicular lymphoma

42
Q

t(8,14) -> what lymphoma?

A

Burkitt’s

43
Q

t(11,14) -> what lymphoma?

A

Mantle cell