Neurology Flashcards
Indications for thrombectomy in aute ischaemic stroke?
- location of lesion
- timing
Location: large vessel occlusion -> ICA, M1, proximal M2, basilar
Timing: less than 6 hours from symptom onset. Can perform up to 24 hours from last seen well if there is a large penumbra/core mismatch as identified by CT Perfusion (DAWN trial)
Still need to thrombolyse prior if eligible
Cranial nerve distribution - rule of 4s
4 above pons -> 1-4
4 in pons -> 5-8
4 in medulla -> 9-12 (bulbar)
4 medial structures in Brainstem
Start with M
Motor pathway
Medial lemniscus (part of dorsal column)
Medial longitudinal fasciculus
Motor nucleus (of CN 3,4,6,12)
4 side structures of brainstem
Starting with S
Spinocerebellar pathways
Spinothalamic pathways
Sensory nucleus of CN 5 (large, from pons to medulla)
Sympathetic tract
3rd nerve palsy
Manifestations?
Common causes?
3rd CN -> oculomotor nerve
Supplies:
- levator muscle of eyelid
- 4 extraocular muscles: medial rectus, superior rectus, inferior rectus, and inferior oblique
- contricts pupil through parasympathetic fibres
Clinical presentation:
- diplopia
- ptosis
- “down and out” position
Lesions:
- PCA aneurysms compressing pathway
- ischaemia (diabetes)
- trauma
4th nerve palsy
Manifestations?
Common causes?
4th CN -> Trochlear
Supplies superior oblique muscle -> intorts, depresses in adducted position
Clinical features:
- blurred vision / diplopia
- eye is deviated upwards and outwards
Causes:
- congenital
- trauma
- microvascular
6th cranial nerve palsy
Clinical features?
Causes?
6th CN -> abducens
Supplies lateral rectus -> abducts eye
Clinical features:
- horizontal diplopia
- horizontal gaze palsy
- strabismus
Causes:
- raised ICP causing compression
- tumours
- vascular disease
- inflammation
- trauma
What is Broca’s aphasia?
Other names for it
Where is the lesion?
Non-fluent / Expressive issue
Can’t repeat
Can comprehend perfectly, leading to intense frustration
Lesion -> dominant frontal lobe
What is Wernicke’s aphasia?
Where is the lesion?
Fluent aphasia. Receptive issue, cannot comprehend
Cannot repeat
Lesion -> Dominant temporal lobe
What is conduction aphasia?
Where is the lesion?
Mixture between Broca’s and Wernicke’s
Able to comprehend, fluent but paraphasic errors common
Not able to repeat
Lesion -> Arcute fasciculus (connection between Broca’s and Wernicke’s area)
What is transcortical motor / sensory aphasia?
What type of lesion?
Transcortical motor aphasia -> expressive aphasia but CAN repeat
Transcortical sensory aphasia -> receptive aphasia but CAN repeat
Lesion -> Classically watershed infarcts that spare main language centres of Broca’s and Wernicke’s but affect other areas
What is Horner’s syndrome?
Where is the lesion?
Triad:
Ptosis
Miosis
Anhydrosis
Lesion = in sympathetic tract. Runs with lower brachial plexus around lung apex up to brainstem
Internucleur ophthalmoplegia
What is the clinical finding?
Where is the lesion?
Causes?
INO = impaired horizontal eye movements with weak adduction of the affected eye, and abduction nystagmus of the contralateral eye
Convergence is NORMAL.
Lesion = in medial longitudinal fasciculus (usually in pons, can be midbrain). MLF connects 6th CN on one side to 3rd CN on contralateral side so eyes move in same direction horizontally
Eye that cannot adduct = side of the lesion
Causes: MS (particularly if bilateral), stroke
Corticospinal tract:
What does it do?
Where does it travel?
-> where do the fibres cross?
Key motor pathway
Long tract that descends from primary motor cortex in frontal lobe
- through internal capsule
- crux cerebri
- basis pontis
- cross over at level of pyramids in lower medulla
- meet lower motor neurons in anterior horn

Spinothalamic tract
Major function?
Where does it run?
Responsible for pain and temperature sensation
Receives input at posterior horn
- decussates over 2-3 spinal segments while ascending
- through brainstem to thalamus
- primary sensory cortex in parietal lobe

Dorsal Column
What is it’s main function?
Where does it run?
Responsible for proprioception and vibration sensation
Input through dorsal root ganglion
- ascends entire spinal cord
- crosses over to contralateral medial lemniscus in lower medulla
- ascends to thalamus
- primary sensory cortex in parietal lobe

What is Brown-Sequard Syndrome?
Where is the lesion?
Cord hemisection
- Ipsilateral UMN weakness below level of lesion (corticospinal)
- ipsilateral proprioception/vibration loss below level of lesion (dorsal column)
- contralateral pain and temprature loss 1-2 levels below lesion (spinothalamic)
- ipsilateral LMN and sensory loss AT level of lesion
What is Central Cord Syndrome?
Where is the lesion?
Central cord lesion, usually syrinx
- suspended sensory level = loss of pain/temperature in adjacent dermatomes at level of lesion
Larger lesions -> will involve LMNs, then corticospinal tract and spinothalamic tract
What is Anterior Cord Syndrome?
Where is the lesion?
Loss of all function, except dorsal column preserved (proprioception / vibration)
Caused by occlusion of anterior spinal artery
Lacunar syndromes:
Name 5 classic lacunar syndromes
- Pure motor (internal capsule or basis pontis)
- Pure sensory (thalamic)
- Ataxic hemiparesis (internal capsule, basis pontis and corona radiata)
- Dysarthria/clumsy hand (basis pontis)
- Mixed sensorimotor (thalamus + internal capsule)
What are the absolute contraindications to thrombolysis?
Contraindications:
- extensive hypoattenuation on CT
- current or previous ICH
- intracranial tumour
- severe head trauma last 3 months
- intracranial / intraspinal surgery
- plts <100
- INR >1.7
- APTT >40
- Clexane last 24 hours
- possible endocarditis
- active GI / other bleed
- aortic arch dissection
What medication do we use for thrombolysis?
Within what time frame can it be given?
Alteplase 0.9mg/kg
Current guidelines -> within 4.5 hours of symptom onset
What should BP be before giving thrombolysis?
< 180 / 105
Thalamus =
Blood supply from which artery?
4 nuclei -> function of each?
Blood supply = PCA
Centre of all sensory input. Pure sensory loss-> classically thalamic injury
Anterior nuclei = language and memory
Lateral nuclei = motor and sensory
Medial nuclei = arousal and memory
Posterior nuclei = visual
