Statins and Fibrates Flashcards
1
Q
Give an example of a statin.
A
Simvastatin
2
Q
How do statins work?
A
Competitively inhibit HMG-CoA reductase, the rate limiting step of cholesterol synthesis in hepatocytes
3
Q
In what type of high cholesterol are statins ineffective?
A
Familial hypercholesterol, where HDL receptors are missing
4
Q
When are statins given in the day?
A
At night (orally)
5
Q
What are adverse effects of statins?
A
Myositis, and rarely rhabdomyolosis (especially if combined with fibrates)
6
Q
Are fibrates and statins often combined?
A
No (due to side effects)
7
Q
What drug class is first line for high triglyceride levels?
A
Fibrates
8
Q
When should fibrates be avoided?
A
In alcoholics
9
Q
What are fibrates agonists of?
A
PPARa
10
Q
Which has more adverse effects, statins or fibrates?
A
Fibrates
