Drugs acting on RAAS

Question 1

What are ACE Inhibitors and ARBs used for?

Answer 1

Hypertension and cardiac failure

Question 2

As renal sympathetic nerve activity increases, what happens to renal perfusion pressure and glomerular filtration?

Answer 2

Decrease

Question 3

What does ACE do?

Answer 3

Convert Angiotensin 1 to Angiotensin 2

Question 4

What does renin do?

Answer 4

Convert Angiotensinogen to Angiotensin 1

Question 5

Which receptors are activated in the RAAS?

Answer 5

AT1 smooth muscle receptors

Question 6

Is there increased release of sympathetic release of noradrenaline from sympathetic nerves in RAAS?

Answer 6

Increased

Question 7

Does the RAAS cause contraction or relaxation of vascular smooth muscle?

Answer 7

contraction

Question 8

Where is aldosterone secreted from?

Answer 8

adrenal cortex

Question 9

What does aldosterone cause?

Answer 9

tubular sodium reabsorption and salt retention

Question 10

What is aliskiren an example of?

Answer 10

Renin inhibitor

Question 11

Which of ACE inhibitors and ARBS block inactivation of bradykinin?

Answer 11

ACE I’s

Question 12

What do ACE I’s do to preload and afterload?

Answer 12

Decrease

Question 13

Do ACE I’s have an effect on cardiac contractility?

Answer 13

No

Question 14

Do ACE I’s abolish aldosterone release?

Answer 14

No, but do reduce it

Question 15

Where do ACE I’s have their greatest effect?

Answer 15

brain, heart, kidneys

Question 16

When are ACE I’s and ARBs contraindicated?

Answer 16

pregnancy, bilateral renal artery stenosis