Statins

Question 1

First line familial hypercholesterolaemia

Answer 1

High intensity statin

Question 2

Statins and pregnancy

Answer 2

If considering pregnancy they should stop taking their statin 3 months before attempting to conceive

Question 3

Statins and contraception

Answer 3

Patients should be on contraception during treatment and 1 MONTH after

Question 4

Statin monitoring requirement

Answer 4

Before:
- Lipid profile
- Renal function
- Liver enzymes
- Creatine kinase
- Blood glucose conc

At 3 months:
- Blood glucose
- Liver enzymes

At 12 months
- Liver function

Question 5

Which statins need to be taken at night

Answer 5

Simvastatin
Pravastatin
Fluvastatin

Question 6

Dose adjustments in statins

Answer 6

Atorvastatin - 10mg daily with ciclosporin

Rosuva- 5mg daily with clop, bezeafibrate, fenofibrate, ciprofibrate

Simva- Max 20mg with amlodipine, amiodarone, verapamil. ranolazine, diltazem

Question 7

Key counselling with statins

Answer 7

Avoid grapefruit juice
Muscle weakness
Cough, dyspnea or sob should be reported