Statins

Question 1

Statin MOA

Answer 1

HMG-CoA reductase inhibitor

Question 2

High intensity statin

Answer 2

Atorvastatin 40-80 mg

Rosuvastatin 20-40 mg

Question 3

Moderate intensity statin

Answer 3

Rosuvastatin 5- 10 mg
Lovastatin 40 mg 
Simvastatin 20-40 mg
Pravastatin 40- 80 mg
Atorvastatin 10-20 mg

Question 4

Low intensity Statin

Answer 4

Lovastatin 20 mg

Pravastatin 10-20 mg

Question 5

Statin ADE

Answer 5

GI upset
SAMS
Rhabdomyolysis

Question 6

Statin are all metabolized by ___ with the exception of ___

Answer 6

CYP450, pravastatin

Question 7

Statin + ___ increases risk of rhabdomyolysis

Answer 7

Fibrate

Question 8

Start on low doses of statin if

Answer 8

pt on 3A4 inhibitor 
renal insufficiency (exception: atorvastatin)

Question 9

Contraindication with simvastatin

Answer 9

Intraconazole, Ketoconazole, Posaconazole

Erythromycin, Clarithromyscin, telithromycin

Question 10

Do not exceed 10 mg Simvastatin with

Answer 10

Amiodarone
Verapamil
Diltiazem

Question 11

Do not exceed 20 mg simvastatin with

Answer 11

Amlodipine

Question 12

Pravastatin is metabolized by

Answer 12

CYP450

Question 13

Characteristics predisposing pt to statin SE

Answer 13

multiple/serious comorbidities
history of previous statin intolerance or muscle disorders
unexplained ATL elevations >3x normal
>75 years of age

Question 14

Rhabdomyolysis

Answer 14

condition resulting in muscle cell breakdown

can lead to renal failure or other organ failure

Question 15

Signs of Rhabdomyolysis

Answer 15

Muscle pain, tenderness, weakness

Dark urine, fever, malaise, N/V

Elevated CK