PCSK9 inhibitors

Question 1

Proprotein convertase subtilisin/kexin type 9 (PCSK9) is

Answer 1

gene expressed in the liver in response to intracellular cholesterol levels

Question 2

PCSK9 is regulated by

Answer 2

SREBP

statins activate SREBP

Question 3

PCSK9 inhibitor MOA

Answer 3

inhibition of PCSK9= increase in LDL receptors = decrease in LDL in blood

Question 4

PCSK9 drugs include

Answer 4

Evolocumab
Alirocumab
Bococizumab
Inclinsiran

Question 5

Main reason PCSK9 inhibitors are not used regularly

Answer 5

Cost $$$