Stahylcoccus Flashcards
If gram positive and Cluster catalase positive, what bacteria genus is it?
Staphylococcus
Staphylococcus Aureus
Gram-positive, non-fastidious, facultative coccus
What is the leading cause of nosocomial infections?
S. Aureus
Special epidemiology of S. aureus
Higher colonization in diabetics, HIV, and burn patients
Predominant site for S. aureus
Anterior nare
Unique characteristic of community MRSA
Produces PVL and sensitive to non-beta lactams
S. Aureus capsule function
Inhibits chemotaxis/phagocytosis, promotes adherence to foreign bodies
S. aureus peptidoglycan
Inhibits phagocytosis, low endotoxin-like activity
S. Aureus teichoic acid
Regulates cationic concentration at cell membrane. Binds to Fn
S. Aureus Protein A
Binds IgG. Inhibits opsonization, complement activation
Enzymes that S. Aureus produces
Coagulase, catalase, hyaluronidase, lipase, nucleases
Coagulase
Converts fibrinogen to fibrin
Catalase
Removes hydrogen peroxide
Hyaluronidase
Hydrolyzes hyaluronic acids. Aids in spreading the the infection
Lipases
Hydrolyzes lipids
Nucleases
Digest DNA/RNA. Aids in spreading infection
Cytolytic toxins of S. aureus
Alpha, beta, delta, gamma, PVL
Exfoliative toxins of S. aureus
A and B. Are sertine proteases that digests the anchors int eh stratum granulosum. Most prevelant in neonates. Made by 30-50% of strains
Enteroteoxins (A-R) and TSST-1 in S. aureus
are superantigens that act systemically. Cause non-specific T cell response, so releases an excess of IL-1, TNF, IL-2
S. Aureus action on Ig
Binds to the Fc portion, so improperly coats the bacteria, thus preventing proper opsonization and phagocytosis