Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Microbiology > Prions And DNA Viruses > Flashcards

Prions And DNA Viruses Flashcards

You may prefer our related Brainscape-certified flashcards:
Biology 101 flashcards
1
Q

Transmitted prions

A

Kuru and vCJD

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Inherited prions

A

CJD

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Animal prions diseases

A

Scrapie and Mad Cow (BSE)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Characteristics of animal prion diseases

A

Dementia, amyloidosis, spongiform encephalopathy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What would be the main method of vCJD transmission in humans?

A

Transplants (pituitary growth hormone, cornea, dura mater)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Mean age of symptoms beginning in both vCJD and CJD

A

VCJD: 28
CJD: 68

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Erythrovirus diseases

A

Fifth disease (face rash)
Aplastic crisis (sickle cell)
Acute polyarthritis
Spontaneous abortion

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Pathology of erythrovirus

A

Kills erythrovirus precursors
1st response: viremia and anemia
2nd response: immune/rash/arthralgia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Most common strains of HPV

A

1-4, 16, 18, 31, 45, 52, 58

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

HPV Pathology

A

Warts in keratinized skin, hyperplasia, koilocytes, inactive p53

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

HPV diseases

A

Papillomas, Laryngopapillomas, cervical dysplasia/carcinoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Vaccines for HPV

A

HPV9, Guardasil, Types 6/11/6 in high risk groups

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

BK and JC epidemiology

A

Very common latent infection, only causes disease in immunocompromised

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Where is the BK virus commonly found?

A

Kidney (associated with UTIs)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What disease is associated with JC virus?

A

Progressive Multifocal leukoencephalopathy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Adenovirus transmission

A

Aerosol and fecal-oral (common in kids and unsanitary conditions)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Which virus is heavily used in gene replacement therapy?

A

Adenovirus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

What vaccines are used for the adenovirus?

A

Types 4 and 7 used in military

19
Q

Adenovirus Diseases

A 
Pharyngitis ± pink eye
Acute Respiratory Tract Disease
Colds*
Conjunctivitis/keratoconjunctivitis
GI/diarrhea
Intussusception*
20
Q

What makes HSV a unique virus?

A

Encodes it’s own DNA polymerase

21
Q

What nerves are typically infected by HSV?

A

Peripheral sensory nerve ganglia (trigeminal or sacral ganglia)

22
Q

Tzanck smear is used to diagnose what?

A

HSV to reveal syncytia (giant, multinucleated cell) and Cowdry type A inclusions

23
Q

What is the most common cause of sporadic encephalitis?

A

HSV 1

24
Q

What is the most common cause of postnatal herpes encephalitis?

A

HSV 2. 15% of newborns die

25
Q

Herpetic Whitlow

A

Typically HSV 1 on the distal finger

26
Q

Varicella-Zoster virus

A

Chicken pox in young
Shingles in older (16 and up). Reactivation of HHV-3
SandS:papules, pustules, vesticles, shallow ulcer, some adults may get interstitial pneumonia, can be passed prenatally**leading to CNS abnormality

27
Q

What vaccines are used for varicella-zoster?

A

Varivax (live) and Zostavax (live)

28
Q

Epstein-Barr virus

A

Targets B cells mitogen (mitosis). T cells resolve the infected B cells, leads to T-cell lymphocytosis (swollen glands/spleen/liver, atypical or Downey cells). Heterophile mononucleosis

29
Q

Diseases caused by EBV

A

Infectious mononucleosis
Laryngitis
Hepatitis
Encephalitis, aseptic meningitis

30
Q

EBV Cancers

A

Burkitt’s lymphoma (Africa-malaria)
Hodgkin’s lymphoma
Nasopharyngeal carcinoma
Hairy oral leukoplakia (AIDS)

31
Q

Cytomegalovirus

A

Primarily opportunistic. Can be passed thru the placenta. Owl’s-eye cells to dx**. Most common cause of congenital defects

32
Q

CMV diseases

A

Ctyomegalic inclusion disease
Transplant/transfusion infection
CMV mono

33
Q

Human lymphotrophic virus

A

HHV 6/7. High fever with a short lived rash

34
Q

Kaposi’s Sarcoma Virus

A

HHV8. Common in AIDS pts and Mediterranean area.

35
Q

Kaposi’s sarcoma disease

A

Black lesions

36
Q

Variola

A

Largest human virus. Brick-shaped.

Only DNA virus that replicates in the cytoplasm

37
Q

Disease caused by variola

A

Smallpox : crater-form lesions. Eradicated in 1980. Breaks down skin barrier to infection. Dx via Guarneri inclusion body

38
Q

Molluscum Contagiosum Virus

A

Poxviridae. Typically spread contact. AIDS associated. Cells look like clam shells. Expressible caseous core

39
Q

Animal Pox viruses

A

Cowpox, Monkeypox, pseudocowpox. Orf (sheep). Self limiting disease.

40
Q

Pathology of Hep B

A

Tc Cells kill HBsAg expressing hepatocyte. Integrates into hepatocyte DNA in hepatocarcinoma. URQ pain**

41
Q

Diseases caused by Hep B

A

Type B hepatitis
HBV-HDV Co-infection
Primary hepatocellular carcinoma.

42
Q

What is the caveat for having Hep D?

A

You must have Hep B to have Hep D. The reverse in not true

43
Q

What causes the yellow skin color in jaundice due to liver failure?

A

Bilirubin

Microbiology (10 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions