Stable Angina Flashcards

1
Q

What is angina?

A

Discomfort in the chest and/or adjacent areas associated with myocardial ischaemia but without myocardial necrosis

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2
Q

Why does angina happen?

A

Mismatch between supply of oxygen and metabolites to the myocardium and the myocardial demand for them

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3
Q

What causes angina?

A

Obstructive coronary atheroma
Coronary artery spasm
Coronary inflammation

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4
Q

What is the most common cause of angina?

A

Obstructive coronary atheroma

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5
Q

What are the very unlikely causes of angina?

A

Reduced oxygen transport

Pathologically increased myocardial oxygen demand

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6
Q

What can cause angina because of reduced oxygen transport?

A

Anaemia

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7
Q

What can cause angina because of increased myocardial oxygen demand?

A

LV hypertrophy

Thyrotoxicosis

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8
Q

Why does hypertrophy cause angina?

A

Because there is more tissue to supply blood to but not enough blood so there is ischaemia which causes pain

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9
Q

What can cause LV hypertrophy?

A

Hypertension
Aortic stenosis
Hypertrophic cardiomyopathy

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10
Q

When does myocardial oxygen demand increase?

A

Increased heart rate

Increased blood pressure

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11
Q

Why does angina happen?

A

Because of myocardial ischaemia

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12
Q

Where is the typical distribution of pain or discomfort with angina?

A

On the left top side of the chest and going down the medial part of the left arm

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13
Q

What is the key characteristic of stable angina?

A

It happens on exertion and goes away after rest

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14
Q

In the blood vessels what causes stable angina?

A

Obstructive plaque that covers 70% or more of the lumen

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15
Q

When there is spontaneous rupture of a plaque and local thrombosis with a degree of occlusion what is this called?

A

Acute coronary syndrome

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16
Q

What is the typical character of pain associated with angina?

A

Tight band
Pressure
Heaviness

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17
Q

Where are the radiation sites for angina pain?

A

Neck
Jaw
Down arms

18
Q

What aggravates stable angina?

A

Exertion

Emotional stress

19
Q

What improves angina rapidly?

A

GTN

Physical rest

20
Q

What characteristics make angina less likely?

A
Sharp/stabbing pain 
Associated with body movement or respiration 
Very localised 
Superficial 
No pattern to pain 
Often occurring at rest 
Begins after exercise
Last for hours
21
Q

What symptoms can myocardial ischaemia present as without angina?

A

Breathless on exertion
Excessive fatigue on exertion
Near syncope on exertion

22
Q

Who is more likely to present with myocardial ischaemia without angina?

A

Elderly

Diabetes mellitus

23
Q

What are the risk factors for coronary artery disease?

A
Age 
Gender 
Family history 
Genetic factors 
Smoking 
Lifestyle 
Diabetes mellitus 
Hypertension 
Hyperlipidaemia
24
Q

What should you look for on examination of stable angina?

A
Tar staining 
Obesity 
Xanthalasma 
Corneal Marcus 
Hypertension 
Abdominal aortic aneurysm atrial bruits, absent or reduced peripheral pulses 
Diabetic retinopathy
25
What are some exacerbating or associated conditions to stable angina?
``` Anaemia Tachycardia Aortic stenosis Hyperthyroidism Mitral regurgitation Heart failure ```
26
What are you looking for in anaemia?
Pallor
27
What are you looking for in hyperthyroidism?
Tachycardia Tremor Hyper-reflexia
28
What are you looking for in aortic stenosis?
Ejection systolic murmur
29
What are the signs of heart failure?
Basal crackles Elevated JVP Peripheral oedema
30
What investigations can be done for stable angina?
``` Full blood count Lipid profile Fasting glucose Electrolytes Liver function tests Thyroid function tests Chest x-ray Electrocardiogram Exercise tolerance test Myocardial perfusion imaging CT coronary angiography Coronary angiography ```
31
What are the treatment strategies for stable angina?
Address risk factors Drugs to reduce disease progression and symptoms PCI CABG
32
What is the medical treatment for disease progression?
Statins ACE inhibitors Aspirin
33
What affect do statins have?
Reduces LDL-cholesterol deposition in atheroma so stabilises them reducing plaque rupture and ACS
34
What affect do ACE inhibitors have?
Stabilises endothelium and reduces plaque rupture
35
What affect does Aspirin have?
Protects endothelium and reduces platelet activation
36
What is the medical treatment for relief of symptoms?
``` Beta blockers Calcium channel blockers Ik channel blockers Nitrates Potassium channel blockers ```
37
What do calcium channel blockers do?
Produce vasodilation
38
What do Nitrates do?
Produce vasodilation
39
What do beta blockers do?
Reduce myocardial work and have anti-arrhythmic effects
40
What is PCI?
Percutaneous coronary intervention such as coronary angioplasty and stenting. Squashes plaque into walls with balloon and stent
41
What is CABG?
Coronary artery bypass surgery is often the best option for stable angina but is significantly more risky than PCI