SRY gene Flashcards

1
Q

SRY

A

Requires to develop testes, which then develop

Sertoli cells and Leydig cells

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2
Q

Sertoli cells

A

Produces MIF, which degenerates Paramesonephric (Mullerian duct, female internal genitalia)

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3
Q

No sertoli cells or MIF

A

Develop both male and female internal genitalia

Male external genitalia

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4
Q

Leydig cells

A

Produces testosterone, which converts mesonephric (Wolffian) to male internal genitalia (except prostate)

Testosterone gets converted to DHT by 5alpha reductase peripherally

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5
Q

DHT

A

Converts genital tubercle and urogenital sinus to

male external genitalia and prostate

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6
Q

5alpha-reductase deficiency

A

Male internal genitalia,

Ambiguous external genitalia until puberty.

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