Spring Test 3 Flashcards
3 functions of the cerebellum
But the primary function is:
- Regulates equilibrium
- Muscle tone and posture
- Motor Coordination for voluntary movements (in near future and during execution)
Motor adaptation
The three deep nuclei of the cerebellum are the:
The _ has two parts, the _ and the _
Dentate
Interposed Nucleus
Fastigal
Interposed nucleus
Emboliform
Globose
The three cerebellar peduncles connect the _ and the _
Cerebellum
Brainstem
The inferior cerebellar peduncle has two parts:
Where do they get their inputs from?
What do they do?
Restiform body:
inputs from spinal cord and brainstem
monitors muscle and limb movement
Juxtarestiform body:
interconnects vestibular nuclei and cerebellum
Doesn’t say what it does
Middle cerebellar peduncle does what 2 things
- Gets Afferent from contralateral basis pontis
- relays motor signals from cerebral cortex
Superior cerebellar peduncle contains what
Mostly efferent fibers to red nucleus and VL thalamus
Inferior olivary nuclei are involved in what two things
Motor learning
Acquisition of new motor skills
The three layers of the cerebellar cortex are the
Molecular layer
Purkinje cell layer
Granule layer
Cortical afferent fibers are _
Cortical efferent fibers are _
Excitatory
Inhibitory
Synonym for excitatory is _
Synonym for inhibitory is _
Glutaminergic
GABAnergic
Mossy fibers synapse at _
Granule cells
Granule cell axons are called _
They travel perpendicular and through _
Parallel fibers
Purkinje cell axons
_ cells inhibit granule cells
Golgi cells
The three main functions of the cerebellum are:
Equilibrium
Muscle tone and posture
Coordinating voluntary movement
What is fractionated somatotopy
Body part is represented in multiple places in cerebellum
How are the homunculi oriented in the cerebellum
Axial muscles more toward midline
The three functional subdivisions of the cerebellum and the nucleus that each is associated with
Vestibulocerebellum -fastigial nucleus Spinocerebellum -dentate nucleus Pontocerebellum -interposed nucleus
Vestibulocerebellum functions (2)
Control of eye movement in response to head movements
Balance
Spinocerebellum has what functions
Posture and gait
Coordination of trunk and limb movements
Neo/pontocerebellum functions
Planning the timing of movements
Coordination of speech
3 other important functions of the cerebellum
Cognition
Speech
Emotion
The diencephalon is made up of what 4 parts
Thalamus
Hypothalamus
Epithalamus
Subthalamus
The limbic system is made up of what 3 things
Hippocampus
Hypothalamus
Amygdala
Which sensory pathways don’t relay in the thalamus
Olfaction only
What divides the different thalamic nuclei
Internal medullary lamina
Which thalamic nuclei division is the largest
Lateral
Thalamic nuclei consist of what two types of neurons
Projection neurons (output from thal.) Interneurons (inhibitory)
The two types of thalamic inputs are
Specific inputs (from a thalamic nucleus to cortex)
Regulatory inputs (from cortex)
Three categories of thalamic nuclei
- Relay nuclei
- Association nuclei
- Intralaminar & midline nuclei
Relay nuclei receive input from a _ source and project to the _
Subcortical
Cortex
Why is the reticular nucleus particularly important
Everything has to pass through it, so it is a major regulatory nucleus
Why is the reticular nucleus unique?
It has no projections to cortex (unlike all other thalamic nuclei)
Reticular nucleus output:
Inhibitory axons to thalamus
8 thalamic relay nuclei
Anterior Lateral dorsal VA VL VPL VPM MGN LGN
The two main association nuclei
DM
Pulvinar
The DM is associated with what part of the brain
Prefrontal
Pulvinar is associated with what area of the brain
Parietal-Occipital-Temporal complex
The LP nucleus
Type:
Input:
Output:
Association
Parietal lobe
Parietal cortex
The putamen and globus pallidus make up the _
Lenticular nucleus
What passes through the internal capsule
Thalamocortical and corticothalamic fibers
The five parts of the internal capsule and what they are made of
- Anterior limb
a. Lenticular nucleus
b. Caudate - Posterior limb
a. Lenticular nucleus
b. Thalamus - Genu (b/t A&P limbs)
- Retrolenticular (b/h lenticular nucleus)
- Sublenticular part (b/n lenticular nucleus)
Hypothalaums is important in what 5 functions
Autonomic Endocrine Emotional Somatic Maintaining homeostasis
The 4 longitudinal regions of the hypothalamus are:
The 3 medial-lateral regions of the hypothalamus are:
Preoptic
Anterior
Tuberal
Posterior
Lateral
Medial
Periventricular
How does the hypothalamus control the pituitary
Superior and inferior hypophyseal arteries supply the pituitary and transmit hormones
How do pituitary hormones get to the rest of the body
Capillaries from pituitary drain into cavernous sinus then to systemic circulation
3 main types of hypothalamic connections
- Interconnected with limbic system
- Output to pituitary
- Interconnects visceral/somatic nuclei
The two arteries that supply the pituitary
Superior and inferior hypophyseal arteries
Parvocellular: end in _
3 nuclei
Magnocellular: end in _
2 nuclei
Median eminence
Preoptic
Ventromedial
Arcuate
Posterior lobe
Paraventricular
Supraoptic
Parvocellular nuclei control what part of the pituitary?
Magnocellular nucleI?
Anterior pituitary
Posterior pituitary
Two hormones from posterior part?
ADH
Oxytocin
The rest are anterior
Anterior hypothalamus has what autonomic effects
Posterior?
Anterior = parasympathetic
Posterior = sympathetic
The two hypothalamic nuclei that control feeding?
Stimulation and lesion of each do what
Lateral and ventromedial nuclei
Lateral:
Stimulation = feeding
Lesion = refuse food
VM:
Stimulation = refuse food
Lesion = feeding
The ventromedial nuclei of the hypothalamus is involved in feeding as well as _
Rage and fear
3 steps in cortisol release in males
- Corticotropin RH released by paraventricular nucleus
- ACTH release in pituitary
- Increase in cortisol from adrenal gland
what area is activated in males in fight or flight response
lateral prefrontal cortex
other than the 4 F’s, what are 2 other hypothalamic functions
sleep/wake
memory
2 key areas for hypothalamic input
forebrain, esp limbic sys.
brainstem/spinal cord
The main functions of the limbic system are
Feelings
Emotions
Amygdala functions
Emotional responses
Hippocampus functions
Learning
Memory
Main source of Afferent to hippocampus
2 minor sources
Entorhinal cortex
Septal nuclei
Fornix
3 zones of the hippocampus
Dentate
Hippocampus proper (CA1-4)
Subiculum
The two important Efferent from the hippocampus go to the _ and _ front the _ and _
Fornix from the subiculum
Sensory cortex from entorhinal cortex
The fímbria of the hippocampus is continuous with the
Fornix
6 steps of papez circuit
- Cingulate gyrus
- Entorhinal cortex
- Hippocampus
- Fornix
- Mammillothalamic tract
- Anterior nucleus of thalamus to cingulate cortex
Consolidation is what
Storing new info in long term memory
HM had only what kind of memory
Working memory
Left hippo does what
Right?
Language
Spatial tasks
Novel material is more _, as it is more familiar, it moves _
Anterior
Posterior
3 nuclei in the amygdala and what they do
Medial - olfaction
Central - emotional responses
Basolateral - emotional responses
Amygdala Afferents come from
Sensory association areas
General sense of emotional and physical discomfort/comfort to the amygdala comes from _
Orbital cortex and cingulate
Visceral sensory to amygdala comes from
Brainstem and PAG
Vision, taste, hearing, somatosensory to amygdala comes from
Cortex and thalamus
Stria terminalis is what
An amygdala efferent from central nucleus
Ventral amygdalofugal pathway is what and synapses with what
Amygdala efferent
Synapses with nucleus accumbens
Fibers leave the amygdala through what two pathways
Stria terminalis
VAG pathway
Amygdala output to ventral striatum is involved in what
Drive related info to influence decisions about movement
Kluver-Bucy syndrome is what
No fear, male = hypersexual, attention to all sensory stimuli, eat weird things, recognize nothing
Nucleus accumbens is aka
Ventral striatum
Limbic loop is what
Limbic system to ventral striatum -> ventral pallidum -> dorsomedial nucleus of thalamus
VS dopamine release from ventral tegmental area in midbrain
The 4 main parts of the basal ganglia are the:
Striatum
Globus pallidus
Subthalamic nucleus
Substantial nigra
The striatum is made of what 3 parts
Caudate
Nucleus accumbens
Putamen
The lenticular nucleus is made of what things
Putamen
Globus pallidus
The _ separates the P and GP from the C
Posterior limb of the internal capsule
The two types of substantia nigra are: and they are distinguished by _
Compact and Reticular
Pigmented neurons in compact
Reticular is closer to CP
Huntington’s disease is caused by degeneration of what
Striatum
Huntington’s disease symptoms are:
Chorea(rapid movements of face and limbs)
rigidity
cognitive disturbances
When does Huntington’s set in
About 50 years
Basal ganglia movement disorders (3)
Involuntary movement (chorea)
Difficulty initiating movement
Perturbed muscle tone
The 4 circuits of the basal ganglia and what they do
Motor loop -learned movements Cognitive loops -motor intentions Limbic loop -emotional aspects of movement Oculomotor loop -voluntary saccades
T/F the basal ganglia initiates motor movements
FALSE
What is the BG’s role in motor control?
Influence descending motor pathway by modulating cortical activity
1-4 of the BG motor loop
- Somatosensory and motor cortex
- Striatum (mostly putamen)
- GPi
- VA/VL in thalamus
Then back to somatosensory/motor cortex
BG cognitive loop is involved in what two things
Motor learning
Planning movements ahead (esp. complex)
When a motor task is practiced extensively, which loop is involved?
Motor loop (instead of cognitive loop)
The cognitive loop steps
Prefrontal cortex
Caudate
Globus Pallidus
VA
Back to prefrontal cortex
Limbic loop does what
Gives expression to emotions (smile, gesture, aggressive posture etc)
Steps in the limbic loop
From inferior prefrontal cortex
Through ventral striatum
Ventral pallidum
DMN
Back to inferior prefrontal cortex
The BG oculomotor loop goes from what parts
Frontal eye field & posterior parietal cortex
Caudate
SN reticular part
VA
Then back to 1st
What part of the oculomotor loop is activated when eyes are fixed on an object?
SN reticular part
What is disinhibition and of what part is it a major feature
It is stopping the inhibition by adding a silent neuron after the inhibiting neuron
It’s a major feature of neuronal activity in the basal ganglia
Basic circuit of basal ganglia
Cerebral cortex
Striatum
GPi
Thalamus
If the GPi is less active, what happens to the thalamus and cortex (direct pathway)
- Less inhibition on thalamus
- Increased thalamic excitation to cortex
- More cortical output
5 steps in direct pathway
- (Excitatory) Corticostriate fibers activate (inhibitory) neurons in striatum
- Striatum inhibits GPi
- Thalamus disinhibited
- Thalamus activates cortex
- Increased cortical output
In general, the indirect pathway does what
Disfacilitates neurons to suppress unwanted movements
Main difference between direct and indirect BG pathways
Indirect has excitation of GPi ultimately resulting in less cortical output
What is in the indirect pathway that isn’t in direct
Subthalamus
Hemiballismus symptoms
Flailing limb movements
Parkinson’s disease is due to what
Degeneration of dopaminergic fibers in the substantia nigra
Substantia nigra reticular part input is similar to that of the _
GPi
Nigrostriatal fibers have two pathways _ and _ based on _
D1/D2
Dopamine receptor expression
D1 receptors are _, D2 receptors are _
D1: facilitatory
D2: inhibitory
How to treat parkinson’s?
Levodopa - replace dopamine lost
Pallidotomy - take out globus pallidus
From an external view, how can you tell if you are looking at a R or L tympanic membrane
The lateral process of the malleus will point up and to the side it’s on (up/right for right side)
Approximately, what are the dimensions of the middle ear cavity
10 x 10 x 6 mm
The two regions of the middle ear are:
Tympanic cavity proper
Epitympanic recess
Superiorly, the epitympanic membrane is continuous with the _
Aditus of the mastoid antrum
The _ m. Runs parallel to auditory tube, the _ m. Runs perpendicular to it
Levator veli palatini
Tensor veli palatini
The walls of the middle ear:
Roof: tegmen tympani Floor: jugular wall Lateral: tympanic membrane Medial: inner ear Ant: carotid wall Post: mastoid wall
The promontory in the middle ear is _ and it it is on the _ wall
Protuberance facing tympanic membrane
Medial
The oval window is also called _ and receives _ and is located _
Round window is also called _
Fenestra vestibuli
Receives base of stapes
Under base of stapes on medial middle ear
Fenestra cochlea
(Membrane covered)
The two prominences on the medial wall of the middle ear are the _ that covers the _ and the _ that covers the _
Facial canal
Facial nerve
Lateral semicircular canal
What tendon is on the medial wall of the middle ear
Tensor tympani
What is the origin of the stapedius and on what wall is it
Pyramidal eminence
On posterior wall (mastoid)
Pharyngotympanic tube and middle ear have what kind of epithelial tissue
P tube: ciliated pseudostratified columnar
mid. Ear: simple squamous
The tympanic membrane is attached to the _ bone, which is attached to the _, which is attached to the _ which is attached to the oval window
Malleus
Incus
Stapes
The two muscles of the middle ear are:
What do they do
Tensor tympani
Stapedius
Act to reduce oscillations of ossicles
Protects inner ear from injury during loud noises
What is the smallest striated muscle in the body
Stapedius
Stapedius is innervated by _
CN VII
Tensor tympani m. Is innervated by+
CN V3
Middle ear arteries:
Veins:
Drain to?
Tympanic branches (ant., inf., sup., stylomastoid, caroticotympanic)
Accompanying veins.
Drain to sup. Petrosal sinus or pterygoid plexus
Chorda tympani passes between _ and _ in the middle ear, then goes and travels with _ and eventually supplies _ with _
Malleus and incus
Lingual n.
Anterior 2/3 tongue with special sensory
Greater petrosal is a branch off _
Carries _ fibers to _
Joins _ to form _
Geniculate ganglion of VII
P-symp fibers to pterygopal. Gang
Deep petrosal to form n. Of pterygoid canal
Tympanic plexus covers _
It’s formed by _ nerves
Promontory in middle ear
Caroticotympanic nerves
Lesser petrosal n. Comes off the _
Tympanic plexus
Lesser petrosal carries _ to otic ganglion
P-symp fibers
Otic ganglion supplies _ to the _
P-symp to the parotid gland
The cochlea begins at the _ and ends at the _
Oval window
Round window
The fluid between bony and membranous labyrinths is _ it is similar to _ and _ and has a _ charge
Perilymph
Extracellular fluid and CSF
+
Fluid in membranous labyrinth is _. It is similar to _ and has a _ charge
Endolymph
Intracellular fluid
- charge
Endolymph is secreted by _ cells
Stria vascularis
Endolymph is reabsorbed in the _
Endolymphatic sac
Auditory and vestibular receptors are _ within the _
Hair cells
Membranous labyrinth
The apical part of stereocilia projects into _ and the basal surface synapses with _ of _
Endolymph
Peripheral processes of CN VIII
Tallest stereocilia
Project into what
Kinocilium
Gelatinous mass