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Pathology > Spr 16- Test 3- Castleman > Flashcards

Spr 16- Test 3- Castleman Flashcards

1
Q

Intestinal adenocarcinoma in the dog occurs most commonly in which segment?

A

Large intestine (Colon/rectum) >55% (SI 45%)

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2
Q

All of the following often result in generalized (diffuse) splenomegaly EXCEPT? Histoplasmosis, Septicemic salmonellosis, Lymphoma, Hemangiosarcoma, Congestion

A

Histoplasmosis

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3
Q

The oral/pharyngeal neoplasm in dogs least likely to metastasize is? @Gingival melanoma
@Fibrosarcoma on the hard palate
@Tonsillar squamous cell carcinoma
@Periodontal fibromatous epulis

A

@Periodontal fibromatous epulis (expansile, non-invasive)
*********
Gingival melanoma (70% met)
Fibrosarcoma on the hard palate (10-20% met)
Tonsillar squamous cell carcinoma (98% met)

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4
Q

Stem cells for epithelial renewal in the small intestine are present in? (2 pt.) @Villus tips
@Crypts
@A and B

A

Crypts (page 1 slides, hard to see text)

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5
Q

The most common form of pulmonary neoplasia is? (2 pt.) @Metastatic neoplasia
@Pulmonary adenoma
@Pulmonary fibrosarcoma
@Pulmonary osteosarcoma @Pulmonary adenocarcinoma

A

Metastatic neoplasia

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6
Q 
All of the following forms of lung lesions are reversible EXCEPT? (2 pt.) 
@Alveolar emphysema
@Alveolar edema
@Bronchiectasis
@Compressive atelectasis 
@A and C
A

Bronchiectasis and Alveolar emphysema are irreversible, so A and C

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7
Q

All of the following are common features of acute bacterial bronchopneumonia in cattle EXCEPT?
Abundant alveolar exudates that includes neutrophils
Diffuse pulmonary distribution
Increase firmness of affected lung
Concurrent fibrinous pleuritis
Bronchiolar oriented inflammatory infiltrate in alveoli

A

Diffuse distribution is false, per notes: “cranioventral sometimes locally extensive”

Unable to confirm: Bronchiolar oriented inflammatory infiltrate in alveoli

All true: Grossly red and firm, cranioventral, locally extensive, alveolar exudate with neutrophils; locally extensive fibrinous pleuritis

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8
Q

Which of the following function as stem cells for epithelial repair in pulmonary alveoli?
@Mucous cells
@Nonciliated bronchiolar epithelial cells
@Basal cells
@Type 1 alveolar epithelial cells
@Type 2 alveolar epithelial cells

A

Type 2 alveolar epithelial cells

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9
Q 
Which of the following contain toxins activated by ruminal microflora and/or pulmonary cytochrome P450 monoxygenase that can induce interstitial pneumonia in cattle?
@Purple mint (Perilla mint)
@Mold damaged sweet potatoes
@Feed containing L‐tryptophan 
@A, B
@A,B,C
A

A,B, and C pg 20 and 53 (Stinkwood/zieria is also one of these toxins)

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10
Q

What mechanism accounts for some respiratory viruses being able to induce chronic pneumonia and diffuse interstitial pneumonia?
@They replicate in type 1 epithelial cells
@They replicate in type 2 epithelial cells
@They evade or suppress immunological defense mechanisms

A

Confirmed correct answer: They evade or suppress immunological defense mechanisms

They DO replicate in type 2 epithelial cells (pg 16) in acute pneumonia, but cannot be chronic without the suppression- per Dr. Castleman

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11
Q

According to the distinguished veterinary pathologist and philosopher at large, John M. King, “If it ain’t firm…..”? (2 pt.)
@”…you’re going soft”
@”…you need to train harder”
@”…it may be Spring in New England” @”…it ain’t pneumonia”

A

”…it ain’t pneumonia”?

Unable to find concrete answer, but this is the only reasonable one

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12
Q

Intestinal adenocarcinoma in the cat occurs most commonly in which segment? @Small intestine
@Large intestine

A

SI- 90% (pg 8)

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13
Q

Which of the following viruses causes systemic lymphoid atrophy? (2 pt.) @Canine parvovirus type 2
@Canine distemper virus
@Feline calicivirus
@A, B @A, B, C

A

Parvo and distemper- lymphoid necrosis (pg 6)
Distemper- atrophy (pg 2 lymphoid notes)

Wrong test?

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14
Q

The most common distribution of lymphoma in dogs is? (2 pt.) @Multicentric
@Alimentary
@Thymic
@Cutaneous @Solitary

A

Multicentric

Wrong test?

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15
Q

Ulceration of the nonglandular stomach with fatal hemorrhage occurs most commonly in? (2 pt.) @Pig
@Horse
@Cow
@Rat @Alpaca

A

Pigs!!!!

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16
Q

Bronchiectasis is most often associated with which of the following?@Viral infection
@Fungal infection
@Bacterial infection
@Alveolar emphysema @Interstitial emphysema

A

Bacterial (page 7, SCAVMA)

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17
Q 
(Image question)  A smooth surfaced firm nodule on the gingival around the right lower incisors (arrow) is most consistent with? (2 pt.)
@Lymphoma
@Periodontal fibromatous epulis
@Squamous cell carcinoma 
@Gastrointestinal stromal tumor 
@Carcinoid tumor
A

Likely epulis, but squamous cell carcinoma (pg 10 slides), but often ulcerated

GIST- intestinal and gastric
Carcinoid- intestinal
Lymphoma- intestinal/GI more common

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18
Q

Image Question: This lung from a dog with necrotizing pancreatitis that was firm in dark red areas is most consistent with which of the following morphologic diagnoses? @aspiration pneumonia @embolic pneumonia

A

Aspiration pneumonia

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19
Q

Bronchopneumonia vs interstitial pneumonia- histo features

A

BP: Obstruction of airways, abundant exudate (neut, fibrin, etc), alveoli filled (=grossly stiff); IP: injury to inter-alveolar septa, epithelial necrosis–>type 2 alv thickening of inter-alv septa, mononuclear cells –>fibrosis

20
Q

Vesicular oral lesions induced by all except:

@foot and mouth @thermal injury @vesicular stomatitis @swine vesicular disease virus @bovine papular stomatitis virus

A

Bovine papular stomatitis- causes papules, not vesicles!

21
Q

Ulcerative lesions can be induced by: chronic uremia, calicivirus, BVD, FMD, All

A

All

22
Q

Which oral neoplasm in dogs has LEAST met probability? Tonsillar SCC, periodontal epulis, acanthomatous ameloblastoma, squamous papilloma, leiomyoma

A

Epulis

23
Q

Image: Mouth trauma in calf, purulent exudate- most likely caused by trauma and infection by what?

A

Fusobacterium (other choices given candida, bovine papular virus, FMD, arcanobacterium pyogenes)

24
Q

Image: Bovine abomasum with diffuse pinpoint lesions, most likely cause?

A

Ostertagia ostertagi

25
Q

Image: bovine omasum pale with large red splotches- most likely dx: bracken fern hemorrhage, BVD omasitis, mycotic omasitis, mycobacterial omasitis, bacterial rumenitis

A

Mycotic omasitis

26
Q

Image: dog stomach with large tumor in center- most likely morph dx: lymphoma, SCC, adenocarcinoma, fibrosarcoma, leiomyo/gastrointestinal-stromal tumor

A

leiomyo/gastrointestinal-stromal tumor

27
Q

Image- cat, pale exteriorized intestines- condition most likley: mesenteric volvulus, intestinal lymphangiectasia, lymphoma, intestinal linear foreign body obstruction, internal herniation of SI

A

intestinal linear foreign body obstruction

28
Q

What induces villous atrophy? rotavirus, coronavirus, crypto, parvo, all

A

ALL

29
Q

Which agent induces necrosis of crypt epithelial cells

A

Parvo

30
Q

Which agent most commonly induces fibrinonecrotic enterocolitis

A

Salmonella

31
Q

Which most commonly induces proliferative enteritis

A

Lawsonia intracellularis

32
Q

Which is not a stem cell for epithelial repair in bronchi or bonchioles? mucus cells, ciliated cells, non-ciliated cells

A

Ciliated cells

33
Q

Which serve as stem cells for epith repair in inter-alv septa

A

Type 2 alveolar epithelial cells

34
Q

What is the most common cause of bronchiectasis

A

Chronic bacterial infection

35
Q

Which is reversible- bronchiectasis, bronchiolitis obliterans, atelectasis, alveolar emphysema

A

Atelectasis

36
Q

Cranioventrally distributed pneumonia is most likely? Aspiration, fungal, viral, broncho- or interstitial pneumonia

A

Broncho

37
Q

Two most likely causes of bronchopneumonia

A

bacteria and aspiration

38
Q

If pneumonia is diffuse, least likely cause is? virus, protozoa, toxins, aspiration, bacterial septicemia

A

Aspiration

39
Q

Acute resp viral infections induce which of these lesions? Bronchitis, bronchiolitis, patchy interstitial pneumonia, diffuse interstitial pneumonia

A

Bronchitis, bronchiolitis, patchy interstitial pneumonia

40
Q

Bacterial, viral or dietary pneumotoxins: which will induce the most severe irreversible lung/pleural damage

A

Bacterial because of large amount of neutrophils and fibrin exudate which can only be repaired through fibrosis which obliterates the parenchyma

41
Q

T/F mold damaged corn contains toxins activated by c-p450 mono-oxygenase causing interstitial pneumonia

A

F

42
Q
  1. If pneumonia is diffuse the least likely cause is
    a. Aspiration
    b. Protozoa
    c. Toxin
    d. Virus
    e. Bacteria septicemia
A

Aspiration

43
Q

Name four things that cause ulcerative oral lesions

A

Chronic uremia, calicivirus, BVD, FMD

44
Q
  1. Which of the following oral neoplasms in dogs has the greatest probability of metastasis?
    a. Tonsillar squamous cell carcinoma
    b. Periodontal fibromatous epulis
    c. Acanthomatous ameloblastoma
    d. Squamous papilloma
    e. Leiomyoma
A

Tonsillar squamous cell carcinoma (acanth is invasive but doesnt met, epulis doesnt met, leio not in oral cavity)

45
Q

T/F Most acute viral respiratory lesions are not diffuse

A

True

Pathology (5 decks)

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