Spleen Flashcards
T/F Short gastrics and splenic artery are end arteries
True
T/F Splenic vein is posterior/inferior to splenic artery
True
Most common antibody in spleen
IgM
Red vs. White pulp in spleen
Red: filter for aged/damaged RBC’s
- Pitting: removal of abnormalities in RBC membrane
White: 15% – immunologic
Howell-Jolly bodies vs. Heinz bodies
HJ: nuclear remnants
Heniz: Hgb
What is tuftsin?
An opsonin, facilitates phagocytosis; produced in spleen
What is properdin
Activates alternate complement pathway
Where is accessory spleen most commonly found?
At hilum
Most common non-traumatic condition requiring splenectomy
ITP
What condition is caused by anti-platelet antibodies?
ITP
Is the spleen normal in ITP?
Yes
Should you avoid splenectomy in children < 10 years old?
Yes
Primary and secondary therapy for ITP
Steroid; gammaglobiulin
TTP
Loss of platelet inhibition; leads to thrombosis and infarction; profound thrombocytopenia
Treatment of TTP
Plasmapheresis
Most common cause of death following TTP
Intracerebral hemorrhage, ARF
Highest risk of post-splenectomy sepsis syndrome
Hemolytic disorders or malignancy
How old should you be before a splenectomy in a child
5 years old
Should you vaccinate before or after splenectomy
Before (14 days before elective surgery; 14 days after emergency surgery)
Most common congenital hemolytic anemia requiring splenectomy
Spherocytosis; and ccy
Is splenectomy required in SC anemia?
No; spleen usually auto-infarcts
Stage 1–>4 Hodgkin’s
Stage I: 1 area or 2 areas on same side as diaphragm
2: Non-contig
3. Bilateral diaphragm
4: Liver, bone, lung
Reed-Sternberg cells
Seen in Hodgkin’s lymphoma
Best/Worst prognosis in Hodgkin’s lymphoma subtypes
Predom (best); lymphocyte depleted – worst prognosis
