Spleen

Question 1

Spleen

Answer 1

largest producer of IgM

antigen processing center for macrophages

Question 2

red pulp of spleen

Answer 2

85%

filter for damaged RBCs

Question 3

white pulp

Answer 3

15%
lymphocytes and macrophages
antigen presenting between macrophages and helper T cells

Question 4

Tuftsin

Answer 4

opsonin, facilitates phagocytosis

produced in the spleen

Question 5

Properdin

Answer 5

activates alternate complement pathway

prodeuced in spleen

Question 6

hematopoiesis

Answer 6

occurs in speen before birth and in conditions such as myeloid dysplasia

Question 7

accessory spleen

Answer 7

most commonly found at splenic hilum

Question 8

idiopathic thrombocytopenic puprura

Answer 8

antiplatelets antibiodies (IgG) - bind plts and cause DECREASED platelets
Sxs: petechia, ginigval bleeding, brusing,
TX: steroids, plasmapharesis, gammaglobulin IgG production and source of phagocytosis
SPLENECTOMY IF FAIL seroids

Question 9

Thrombotic thrombocytopenic purpura

Answer 9

assoicated with medical reactions, nfections, inflammation, autoimmune disease
LOSS of platelet inhibition- leads to thrombosis and infarction.
SXS: purpura, fever, mental status changes, renal dysfunction, hematuria, hemolytic anemia
TX: plasmapheresis, steroids, ASA