spermatogenesis Flashcards

1
Q

in order to have a constant production of spermatozoids, males must have adequate secretion of GnRH, what hypothalamic center is the only active in males?

A

tonic center

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2
Q

IN seminiferous tubules at the interstitial compartment we can observe what cells that express what type of receptor to synthesize this specific hormone?

A

leydig cells express LH receptors an synthesize Testosterone

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3
Q

At the adluminal compartment what cells are observed and they express what receptors resulting in the synthesis of what hormone?

A

Sertoli cells express FSH receptors ad synthesize estradiol

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4
Q

Spermiation

A

once formed the release of spermatozoids from Sertoli cells into the lumen of the seminiferous tubule

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5
Q

Cycle of the Seminiferous tubules

A

period of time required for a group of cells in a section of seminiferous tubule to pass through all of the stages

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6
Q

Spermiogenesis

A

morphological conversion of round spermatid into spermatozoa

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7
Q

spermatogenesis

A

cellular mechanisms that provide continuous supply of male gametes

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8
Q

During this phase of the Spermiogenesis the Acrosome forms a distinct cap over nucleus, the remaining Golgi apparatus move away from nucleus and and a primitive flagellum forms from distal centriole

A

the Cap phase

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9
Q

what is the precursor of hormones such as progesterone, estradiol and testosterone?

A

Cholesterol

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10
Q

During this phase of the Spermiogenesis the Manchette migrates towards tail and the mitochondria cluster on the neck of the flagellum

A

The Maturation phase

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11
Q

During this phase of the spermiogenesis the Acrosome continues to spread and develop around the nucleus, the nucleus elongates and the Machete forms- microtubules, postnuclear cap

A

the Acrosomal phase

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12
Q

During the initial phase of the Spermiogenesis the Glogi apparatus packages enzymes that eventually will become the acrosome, also initial arrangement of cellular organelles

A

The Golgi phase

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13
Q

how many meiotic divisions are necessary to reduce a haploid spermatid?

A

2

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14
Q

how long does it take for a spermatogonia cell to become spermatozoid in bulls?

A

60-61 days

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15
Q

what is the normal spermatozoid motility in a semen collection to consider the sample optimal?

A

at least 60%

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16
Q

what is the physiological function of dihydrotestosterone in males?

A

various embryological structures develop, regulates along with prostate function, aids in increasing Sertoli cell, spermatogonial and spermatocyte populations

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17
Q

the presence of a small amount of cytoplasm in the ejaculated spermatozoid is due to

A

over use of the male, epididymal issues, lack of transportation time in epididymis and disease

18
Q

in what organ the spermatozoids mature ad become futile and motile

A

epididymis

19
Q

what hormone causes apoptosis of the surge center in males

A

testosterone transformation to Estrogen

20
Q

where does spermatogenesis occur?

A

Sertoli cells –> seminiferous tubules

21
Q

when does spermatogenesis occur?

A

before puberty

22
Q

spermatogenesis phases;

A

proliferation phase , meiotic phase, differentiation phase

23
Q

Proliferation phase

A

mitotic division of spermatogonia. Stem cell renewal

24
Q

meiotic phase

A

genetic diversity

25
Q

differentiation phase

A

“Spermiogenesis”- differentiation of the spermatozoids, structural changes

26
Q

what changes do spermatids go through during differentiation

A

nucleus is high condensed, acrosome is formed, cell becomes motile, formation of the flagellum, mitochondrial helix

27
Q

spermatozoa=

A

head + tail

28
Q

head=

A

nucleus + acrosome + postnuclear cap

29
Q

tail

A

middle piece + principal piece + terminal piece

30
Q

what happens if there is a disruption of spermatogenesis cycle

A

can lead to short-to-long term stoppage in sperm production

ex: fever, stress, toxins, heat stress

31
Q

how long does it take for a spermatogonia cell to become spermatozoid in rat?

A

approximately 54 days

32
Q

how long does it take for a spermatogonia cell to become spermatozoid in man?

A

75-80 days

33
Q

factors that affect reproductive efficiency in males

A

environment, Nutrition, sexual maturation of the animal, diseases, management of the animal, genetics

34
Q

there is a positive correlation between what assessing scrotal circumference

A

positive correlation between scrotal circumference and testicular weight, number of sperm in testes and number of sperm in epididymis

35
Q

different ways of semen collection

A

electric stimulation, manual collection, teaser, artificial vagina

36
Q

ways to extract semen in bulls and stallions?

A

electro-ejaculator, teaser, artificial vagina

37
Q

what do you look at when doing a semen analysis

A

volume of ejaculate, color and consistency of the ejaculate, concentration of semen, progressive motility, semen morphology, semen viability

38
Q

endogenous factors that affect sperm motility?

A

age, sperm maturation, energy stores, surface and surface-active agents (antibodies, detergents, etc.)

39
Q

exogenous factors that affect sperm motility

A

biophysical and physiological factors, suspending fluids, stimulation- inhibition (prostaglandins, environmental pollutants, hormonal treatments)

40
Q

how to tell semen viability

A

cells that stain dark are no viable as the stain can enter the damaged cell, cells that are therefore not stained are viable. Cells that are not moving are motile = not viable, cells that re moving = viable

41
Q

normal rate of motility in bulls

A

60% motility

42
Q

aging in the testes is associated

A

decline in the number of leydig and sertoli
thickening of the basement membrane of the seminiferous tubules
arrested divisions of germ cells