specific toxicity treatments Flashcards
acetaminophen toxicity - treatment
N-acetylcysteine (replenish glutathione)
AChE inhibitors, organophosphates toxicity - treatment
Atropine>pralidoxime
Antimuscarinic, anticholinergic agonists toxicity - treatment
- Physostygmine
2. control hyperthermia
Amphetamines toxicity - treatment
NH4CL (acidify urine)
Arsenic toxicity - treatment
dimercaprol, succimer
Benzodiazepines toxicity - treatment
Flumazenil
β-blockers toxicity - treatment
saline, atropine, glucagon
Carbon monoxide toxicity - treatment
100% 02, hyperbaric oxygen
Copper toxicity - treatment
penicillamine, trentine
oral zinc
Cyanide toxicity - treatment
Nitrate + thiosulfate, hydroxocobalamin
Digitalis (digoxin) toxicity - treatment
Anti-dig Fad fragments
Gold toxicity - treatment
penicillamine, diercaprol (BAL), succimer
heparin toxicity - treatment
protamine sulfate
flumazenil is the antidote for
benzodiazepines
iron toxicity - treatment
deferoxamine, derasirox, deferiprone, repeated phlebotomy
lead toxicity - treatment
EDTA, dimercaprol, succimer, penicillamine
Mercury toxicity - treatment
dimercaprol, succimer
Methemoglobin toxicity - treatment
Methylene blue, vitamin C
Opioids toxicity - treatment
naloxone
Salicylates toxicity - treatment
NaHCO3 (alkalinize urine), dyalisis
TCAs toxicity - treatment
NaHCO3
Warfarin toxicity - treatment
vitamin K (delayed effect) fresh frozen plasma (immediate)
Bivalirudin toxicity - treatment
not specific –> can attempt to use activated prothrombin complex concentrates (PCC) and/or fibrinolytics (eg. traxenamic acid)
Methanol, ethynele glycol (antifreeze) toxicity - treatment
fomepizole>ethanol, dialysis
arsenic, copper, gold, iron, lead, mercury toxicity - treatment
arsenic –> dimercaprol, succimer
copper –> penicillamine, trentine, oral zinc
lead –> EDTA, dimercaprol, succimer, penicillamine
gold –> penicillamine, diercaprol (BAL), succimer
mercury –> dimercaprol, succimer
iron –> deferoxamine, derasirox, deferiprone, repeated phlebotomy
