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Pharmacology > Drug toxicities > Flashcards

Drug toxicities Flashcards

1
Q

drugs that cause coronary vasospam

A
  1. Cocaine
  2. sumatriptan
  3. ergot alkaloids (Bromocriptine)
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2
Q

drugs that cause cutaneous flushing

A
  1. VANCOMYCIN
  2. Adenosine
  3. Niacin
  4. Ca2+ channel blockers
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3
Q

drugs that cause Dilated cardiomyopathy

A

Anthracyclines (eg. doxorubicin, daunorubicin)

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4
Q

how to prevent antracyclines mediated dilated cardioyopathy

A

dexrazoxane

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5
Q

drugs that cause Torsade de pointes

A

ABCDE

  1. AntiArrhythmics (class IA, III)
  2. AntiBiotics (eg. Macrolides)
  3. AntiCychotices (eg. haloperidol)
  4. AntiDepressants (eg. TCA)
  5. AntiEmetics (ondansetron
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6
Q

torsade de pointes - treatment

A

Magnesium sulfate

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7
Q

other causes of torsade de pointes beside drugs

A

hypokalemia

hypomagnisemia

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8
Q

drugs that cause HPA adrenocortical insufficinecy

A

HPA suppression 2ry to glucocorticoid withdrawal

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9
Q

drugs that cause Hot flashes

A
  1. Clomiphene

2. Tamoxifen

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10
Q

drugs that cause hyperglycemia

A
  1. Tacrolimus
  2. protease inhibitors
  3. Niacin
  4. hydrochlorothiazide
  5. Corticosteroids
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11
Q

drugs that cause hypothyroidism

A
  1. Lithium
  2. amiodarone
  3. sulfonamides
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12
Q

drugs that cause acute cholestiatic hepatitis and jundice

A

Erytrhomycin (Macrolides)

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13
Q

drugs that cause Diarrhea

A
  1. Acamprosate -
  2. Acarbose
  3. cholinesterase inhibitors
  4. colchicine
  5. erythromycin -
  6. ezetimibe
  7. metformin
  8. misoprostol -
  9. orlistat
  10. pramlintide -
  11. quinidine -
  12. SSRIs
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14
Q

drugs that cause Focal to massive hepatic necrosis

A
  1. Halothane
  2. Amanita phalloides (death cap mushroom)
  3. Valproic acid
  4. Acetaminophen
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15
Q

drugs that cause hepatitis

A
  1. Rifampin
  2. Isoniazid
  3. Pyrazinamide
  4. Statins
  5. fibrates
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16
Q

drugs that cause Pancreatitis

A

Drugs Causing A Violent Abdominal Distress

  1. Didanosine
  2. Corticosteroids
  3. Alchohol
  4. Valproic acid
  5. Azathioprine
  6. Diuretics (furosemide, thiazides)
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17
Q

drugs that cause Pill-induced esophagitis

A
  1. Tetracyclines
  2. biphosphanates
  3. Potasium chloride
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18
Q

Pill-induced esophagitis - caustic effects minimized with

A

upright posture and adequate water ingestion

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19
Q

drugs that cause pseudomembranous colitis

A
  1. Clindamycin
  2. ampicillin
  3. cephalosporne
  4. PPIs
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20
Q

Drugs that cause dry cough

A

ACE inhibitors

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21
Q

drugs that cause Pulmonary fibrosis

A
  1. Methotrexate
  2. Bleomycin
  3. Busulfan
  4. Amiodarone
  5. Carmustine
  6. Nitrofurantoin
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22
Q

drugs that cause thrombotic complications

A

OCP

Horomne replacement therapy

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23
Q

drugs that cause thrombocytopenia

A
  1. Heparin
  2. Antiarrhythmics class IA
  3. sulfa
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24
Q

drugs that cause Megaloblastic anemia

A
  1. Phenytoin
  2. Methotrexate
  3. Sulfa drugs
25
Q

drugs that cause Hemolysis in G6PD deficinecy

A
  1. Isonizid
  2. Sulfonamies
  3. Dapsone
  4. Primaquine
  5. Aspirin
  6. Ibuprofen
  7. Nitrofurantoin
26
Q

drugs that cause Gray baby syndrome

A

Chloramphenicol

27
Q

Direct Coombs-positive hemolytic anemia

A
  1. Methyldopa

2. penicillin

28
Q

drugs that cause aplastic hemolytic anemia

A
  1. Carbamazepine
  2. Methimazole
  3. NSAID
  4. Benzene
  5. Chloramphenicol
  6. Propylthiouracil
29
Q

drugs that cause agranulocytosis

A
  1. Clozapine
  2. Carbamazepine
  3. Propylthuouracil
  4. Methimaazol
  5. Colchicine
  6. Ganciclovir
30
Q

drugs that cause fat redistribution

A
  1. Protease inhibitor

2. Glucocorticoids

31
Q

drugs that cause gingival hypeplasia

A
  1. Phenytoin
  2. Ca2+ channel blockers
  3. Cyclosporine
32
Q

drugs that cause gout

A
  1. Pyrazinamide
  2. Thiazides
  3. Furosemide
  4. Niacin
  5. Cyclosporine
33
Q

drugs that cause myopathy

A
  1. fibrates
  2. niacin
  3. colchicine
  4. Hydrxychloroquine
  5. interferon α
  6. penicillamine
  7. statins
  8. glucocorticoids
34
Q

drugs that causeOsteoprosis

A
  1. corticosteroids

2. heparin

35
Q

drugs that cause teeth discoloration

A

Tetracyclines

36
Q

drugs that cause Tendonitis, tendon rupture, and cartilage damage

A

Fluoroquinolones

37
Q

drugs that cause SLE-like syndrome

A
  1. Sulfa drugs
  2. Hydralazine
  3. Isoniazid
  4. Procainamide
  5. Phenytoin
  6. Etanercept
38
Q

drugs that cause Stevens Johnson syndrome

A
  1. Anti-epileptic drugs (esp lamotrigine)
  2. Allopurinol
  3. sulfa drugs
  4. penicillin
39
Q

drugs that cause Photosensitivity

A
  1. Sulfonamifes
  2. amiodarone
  3. Tetracuclines
  4. 5-FU
40
Q

drugs that cause Cinchonism

A
  1. Quinidine

2. Quinine

41
Q

drugs that cause Parkinson like-syndrome

A
  1. Antipsychotics
  2. Reserpine
  3. Metoclopramide
42
Q

drugs that cause Tarditve dyskinesia

A
  1. Antipsychotics

2. metoclopramide

43
Q

drugs that cause Seizures

A
  1. isoniazid (vit B6 deficinecy)
  2. Bupropion
  3. Impipenem/cilastatin
  4. Tramadol
  5. Enflurane
44
Q

drugs that cause antimuscarinic

A
  1. atropine
  2. TCA
  3. HI-blockers
  4. Antipsychotics
45
Q

drugs that cause disulfiram like reaction

A
  1. Metronidazole
  2. certain cephalosporins
  3. griseofulvin
  4. procarbazine
  5. 1st generation sulfonylureas
46
Q

drugs that cause Nephrotoxicity/ototoxicity

A
  1. aminoglycosides
  2. vancomycin
  3. loop diuretics
  4. cisplatin
47
Q

cisplatin toxicity may respond to

A

amifostine

48
Q

Cytochrome P-450 inducers

A
  1. Chronic alcohol use
  2. St John’s wort
  3. Pheyntoin
  4. Phenobarbital
  5. Nevirapine
  6. Rifampin
  7. Griseofulvin
  8. Carbamazepine
49
Q

Cytochrome P-450 substrates

A
  1. Anti-epileptics
  2. Theophilline
  3. Warfarin
  4. OCPs
50
Q

Cytochrome P-450 inhibitors

A
  1. Acute alcohol abuse
  2. Ritonavir
  3. Amiodarone
  4. Cimetidine
  5. Ciprofloxacin
  6. Ketoconazole
  7. Suldonamides
  8. Isonizid
  9. Grapefruit juice
  10. Macrolides (except azithromycin)
51
Q

Sulfa drugs - drugs?

A
  1. Sulfonamide antibiotics
  2. Sulfasalazine
  3. Probenecid
  4. Furosemide
  5. Acetazolamide
  6. Celecoxib
  7. Thiazides
  8. Suldonylureas
52
Q

Patients with sulfa allergies may develop

A
  1. fever
  2. UTI
  3. Steven Johnson syndrome
  4. hemolytic anemia
  5. Thrombocytopenia
  6. Agranulocytosis
  7. urticaria
    SYMPTOMS RANGE FROM MILD TO LIFE THREATENING
53
Q

drugs that cause SIADH

A
  1. carbamazepine
  2. Cyclophosphamide
  3. SSRIs
54
Q

drugs that cause diabetes insibidus

A
  1. Lithium

2. Demeclocycline

55
Q

drugs that cause Fanconi syndrome

A
  1. Tendofovir
  2. Ifosfamide
  3. cisplatin
  4. expired tetracycline
  5. Lead poisoning
56
Q

drugs that cause interstitial nephritis

A
  1. Methicillin
  2. NSAID
  3. Furosemide
57
Q

drugs that cause Hemorrhagic cystitis

A
  1. Cyclophosphamide

2. Ifosphamide

58
Q

drug induced Hemorrhagic cystitis is prevented by

A

coadministration of mesna

Pharmacology (9 decks)

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