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Lab Diagnosis > Specific Proteins 2 > Flashcards

Specific Proteins 2 Flashcards

1
Q

Main components of globulins:

A 
Pre-albumin
Albumin
A1 globulin
A2 globulin 
B globulin
Gamma globulin
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2
Q

Identify the specific proteins of the fractions:

Pre- albumin

A

Prealbumin

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3
Q

Identify the specific proteins of the fractions:

Albumin

A

Albumin

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4
Q

Identify the specific proteins of the fractions:

A1 globulin

A 
A1 anti trypsin 
A1 acid glycoprotein 
A1 lipoprotein
Transcortin
AFP TBG
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5
Q

Identify the specific proteins of the fractions:

A2 globulin

A

Haptoglobulin
A2 macroglobulin
HDL
Ceruloplasmin

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6
Q

Identify the specific proteins of the fractions:

B globulin

A 
B1 and B2 transferrin
LDL
C3-C4
Transferrin 
Hemopexin
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7
Q

Identify the specific proteins of the fractions:

Gamma globulin

A

Ig
Fibrinogen
CRP

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8
Q

Types of plasma proteins:

A

Albumin
Globulin
Fibrinogen

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9
Q

Which specific protein transport the ff:

FA, bilirubin, Ca

A

Albumin

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10
Q

Which specific protein transport the ff:

Iron

A

Transferrin

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11
Q

Which specific protein transport the ff:

Copper

A

Ceruplasmin

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12
Q

Which specific protein transport the ff:

Cortisol, corticosterone

A

Transcortin

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13
Q

Which specific protein transport the ff:

Lipids

A

Lipoprotein

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14
Q

Which specific protein transport the ff:

Free hemoglobin

A

Haptoglobin

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15
Q

Which specific protein transport the ff:

Thyroxine

A

TGB

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16
Q

Which specific protein transport the ff:

Retinol

A

Retinol binding protein

17
Q

The most important in regulation of colloidal osmotic/ oncotic pressure

A

Albumin

18
Q

Combines with elastase and trypsin to protect the hydrolytic damage of tissues and lungs

A

A1 antitrypsin

19
Q

Breakdown thrombin and dissolves blood clot

A

Plasmin

20
Q

Positive acute phase reactants:

A 
CRP - 1000 fold
A1 anti trypsin
Fibrinogen
Haptoglobin
C3, C4
Serum amyloid
21
Q

Negative acute phase reactants

A 
Albumin
Transferrin 
Antithrombin
Transcortin
RBP
22
Q

The fraction that migrates in a position faster than albumin towards the anode

A

Pre albumin

23
Q

Characteristics of prealbumin:

A 
Tetramere structure - MW 62,000 Da
2nd most predominant protein in CSF
One of the smaller serum proteins
Rich in tryptophan
Beta pleated sheet conformation
Short half life - 2 days
24
Q

Functions of prealbumin:

A

Carrier protein for thyroxine - thyroxine binding prealbumin (TBPA) or transthyretin (TTR)

Significant role in vitamin A metabolism - it holds the rretinol binding protein (RBP) in the plasma to prevent it from rapid removal from the circulation by filtration through the kidneys

25
Q

Portion of prealbumin is the source of beta fibrillar amyloid component in ____________________

A

Type 1 familial amyloidotic polyneuropathy

26
Q

Synthetic rate of prealbumin is sensitive to:

A

Adequate nutrition

Alterations in hepatic function

27
Q

Better early indicator of change in nutritional status and an important factor for planning patient management

A

Prealbumin

Low levels is associated with greater risks of mortality and hospitalization

28
Q

True prealbumin is best quantified by:

A

Nephelometry

29
Q

A protein band frequently appears in the prealbumin postion in pts with:

A

Heparin therapy

30
Q

Absence of albumin:

A

Analbuminemia

31
Q

Presence of 2 bands in the albumin region:

A

Bisalbuminemia

32
Q

Decrease level of albumin, typical of nephritic syndrome

A

Hypoalbuminemia

33
Q

Characteristics of albumin:

A

Most abundant protein in normal plasma
Serves as mobile repository of amino acids
General transport or carrier protein
Consists of 585 AA

34
Q

Depression in albumin levels result to serious imbalance of intravascular oncotic pressure manifested clinically by;

A

Peripheral edema

35
Q

Has regions of homology with serum albumin

A

Alpha fetoprotein

Lab Diagnosis (7 decks)

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