Specific Proteins 2 Flashcards
Main components of globulins:
Pre-albumin Albumin A1 globulin A2 globulin B globulin Gamma globulin
Identify the specific proteins of the fractions:
Pre- albumin
Prealbumin
Identify the specific proteins of the fractions:
Albumin
Albumin
Identify the specific proteins of the fractions:
A1 globulin
A1 anti trypsin A1 acid glycoprotein A1 lipoprotein Transcortin AFP TBG
Identify the specific proteins of the fractions:
A2 globulin
Haptoglobulin
A2 macroglobulin
HDL
Ceruloplasmin
Identify the specific proteins of the fractions:
B globulin
B1 and B2 transferrin LDL C3-C4 Transferrin Hemopexin
Identify the specific proteins of the fractions:
Gamma globulin
Ig
Fibrinogen
CRP
Types of plasma proteins:
Albumin
Globulin
Fibrinogen
Which specific protein transport the ff:
FA, bilirubin, Ca
Albumin
Which specific protein transport the ff:
Iron
Transferrin
Which specific protein transport the ff:
Copper
Ceruplasmin
Which specific protein transport the ff:
Cortisol, corticosterone
Transcortin
Which specific protein transport the ff:
Lipids
Lipoprotein
Which specific protein transport the ff:
Free hemoglobin
Haptoglobin
Which specific protein transport the ff:
Thyroxine
TGB
Which specific protein transport the ff:
Retinol
Retinol binding protein
The most important in regulation of colloidal osmotic/ oncotic pressure
Albumin
Combines with elastase and trypsin to protect the hydrolytic damage of tissues and lungs
A1 antitrypsin
Breakdown thrombin and dissolves blood clot
Plasmin
Positive acute phase reactants:
CRP - 1000 fold A1 anti trypsin Fibrinogen Haptoglobin C3, C4 Serum amyloid
Negative acute phase reactants
Albumin Transferrin Antithrombin Transcortin RBP
The fraction that migrates in a position faster than albumin towards the anode
Pre albumin
Characteristics of prealbumin:
Tetramere structure - MW 62,000 Da 2nd most predominant protein in CSF One of the smaller serum proteins Rich in tryptophan Beta pleated sheet conformation Short half life - 2 days
Functions of prealbumin:
Carrier protein for thyroxine - thyroxine binding prealbumin (TBPA) or transthyretin (TTR)
Significant role in vitamin A metabolism - it holds the rretinol binding protein (RBP) in the plasma to prevent it from rapid removal from the circulation by filtration through the kidneys
Portion of prealbumin is the source of beta fibrillar amyloid component in ____________________
Type 1 familial amyloidotic polyneuropathy
Synthetic rate of prealbumin is sensitive to:
Adequate nutrition
Alterations in hepatic function
Better early indicator of change in nutritional status and an important factor for planning patient management
Prealbumin
Low levels is associated with greater risks of mortality and hospitalization
True prealbumin is best quantified by:
Nephelometry
A protein band frequently appears in the prealbumin postion in pts with:
Heparin therapy
Absence of albumin:
Analbuminemia
Presence of 2 bands in the albumin region:
Bisalbuminemia
Decrease level of albumin, typical of nephritic syndrome
Hypoalbuminemia
Characteristics of albumin:
Most abundant protein in normal plasma
Serves as mobile repository of amino acids
General transport or carrier protein
Consists of 585 AA
Depression in albumin levels result to serious imbalance of intravascular oncotic pressure manifested clinically by;
Peripheral edema
Has regions of homology with serum albumin
Alpha fetoprotein
