Mod 2 SLE Flashcards
Hallmark of the systemic rheumatic diseases
Auto-antibodies to nuclear antigens
ANA
True or False:
Definition and significant features of SLE:
SLE is a non organic autoimmune disease.
True
True or False:
Definition and significant features of SLE:
The typical case of SLE has an average of five different circulating antibodies present simultaneously.
False. Three
True or False:
Definition and significant features of SLE:
SLE is most prevalent in women during childbearing years.
True
True or False:
Definition and significant features of SLE:
Patients with SLE demonstrate a homogenous and monoclonal antibody response.
False. Heterogenous and polyclonal antibody response
True or False:
Definition and significant features of SLE:
The disease demonstrates a hyperactive immune system with multiple abnormalities.
True
Presence of one or more auto antibodies that may be directed against components of the surface, cytoplasm, nuclear envelope or nucleus of the cell
Rheumatic diseases
What drugs cause the syndrome of drug-induced lupus?
Hydralazine
Procainamide
Isoniazid
This technique is very sensitive and is an important method for characterization of the specific nature of many auto antibodies
Immunoblotting
Old test, also known as agar gel immunodiffusion
Used to determine immunological specificity
Shows the serum does or does not have antinuclear antibodies
Ouchterlony test
High specificity and sensitivity to SLE. Uses ELISA. General test for: DsDNA antibodies Antihistone antibodies DNP
FANA ( fluorescent antinuclear antibody test)
The most common drug involved in drug induced autoimmunity
Procainamide
Lupus anticoagulant/ antiphospholipid syndrome
Clinical features: Arterial and venous thrombosis Thrombocytopenia Hemolytic anemia Miscarriage
Antiphospholipid antibodies in SLE (APAS)
Has been widely used for detection of antiphospholipid antibodies.
Anionicphospholipid
Cardiolipin
Cardiolipin: identified in SLE pts in 3 ways -
- False positive VDRL test for syphilis
- Lupus anticoagulant assay
- Cardiolipin immunoassay
Antibodies to PCNA proteins
Cell cycle related. Useful probe in the study of agents regulating DNA replication, cell proliferation and transformation
Proliferating Cell Nuclear Antigen Multiprotein Complex
10-20 % in pts with SLE
Association with anti rRNP with major CNS disorder in SLE
Psychotic symptoms
Antibodies to P ribosomal proteins
Pathogenesis of SLE:
DNA anti DNA immune complexes (IgG3) will deposit in the BM as well as in glomeruli and initiate an inflammatory mechanism (foreign body) that will cause the cell lysis —- repeated deposition, inflammation reaction will contribute to kidney damage
Anti SS-A/Ro alone has:
Strongly associated with HLA-DRE 2
Young (
Anti SS B/LA antibodies has strong association with:
Sjogren’s syndrome
Clinical features of anti KI antibody:
Arthritis
Pericarditis
Pulmonary hypertension
True or false. nRNP could not be biochemically isolated from the sm antigen.
True
Associated with major CNS disorder in SLE
Psychotic symptoms
No association shown with cognitive impairments or depression
Antibodies to P ribosomal proteins
The skin lesion is as follows:
Persistent localized erythema Adherent scales Follicular plugging Telangiectasis Atrophy
Chronic discoid lupus erythematosus (CDLE)
Has a characteristic (+) histone auto antibodies
Drug induced lupus erythematosus
Clinical features of: Arterial and venous thrombosis Thrombocytopenia Hemolytic anemia MISCARRIAGE ( most common)
Antiphospholipid antibodies in SLE (APAS)
