Mod 2 SLE

Question 1

Hallmark of the systemic rheumatic diseases

Answer 1

Auto-antibodies to nuclear antigens

ANA

Question 2

True or False:
Definition and significant features of SLE:

SLE is a non organic autoimmune disease.

Answer 2

True

Question 3

True or False:
Definition and significant features of SLE:

The typical case of SLE has an average of five different circulating antibodies present simultaneously.

Answer 3

False. Three

Question 4

True or False:
Definition and significant features of SLE:

SLE is most prevalent in women during childbearing years.

Answer 4

True

Question 5

True or False:
Definition and significant features of SLE:

Patients with SLE demonstrate a homogenous and monoclonal antibody response.

Answer 5

False. Heterogenous and polyclonal antibody response

Question 6

True or False:
Definition and significant features of SLE:

The disease demonstrates a hyperactive immune system with multiple abnormalities.

Answer 6

True

Question 7

Presence of one or more auto antibodies that may be directed against components of the surface, cytoplasm, nuclear envelope or nucleus of the cell

Answer 7

Rheumatic diseases

Question 8

What drugs cause the syndrome of drug-induced lupus?

Answer 8

Hydralazine
Procainamide
Isoniazid

Question 9

This technique is very sensitive and is an important method for characterization of the specific nature of many auto antibodies

Answer 9

Immunoblotting

Question 10

Old test, also known as agar gel immunodiffusion

Used to determine immunological specificity

Shows the serum does or does not have antinuclear antibodies

Answer 10

Ouchterlony test

Question 11

High specificity and sensitivity to SLE.
Uses ELISA.
General test for:
DsDNA antibodies
Antihistone antibodies
DNP

Answer 11

FANA ( fluorescent antinuclear antibody test)

Question 12

The most common drug involved in drug induced autoimmunity

Answer 12

Procainamide

Question 13

Lupus anticoagulant/ antiphospholipid syndrome

Clinical features:
Arterial and venous thrombosis
Thrombocytopenia
Hemolytic anemia 
Miscarriage

Answer 13

Antiphospholipid antibodies in SLE (APAS)

Question 14

Has been widely used for detection of antiphospholipid antibodies.

Anionicphospholipid

Answer 14

Cardiolipin

Question 15

Cardiolipin: identified in SLE pts in 3 ways -

Answer 15

1. False positive VDRL test for syphilis
2. Lupus anticoagulant assay
3. Cardiolipin immunoassay

Question 16

Antibodies to PCNA proteins

Cell cycle related. Useful probe in the study of agents regulating DNA replication, cell proliferation and transformation

Answer 16

Proliferating Cell Nuclear Antigen Multiprotein Complex

Question 17

10-20 % in pts with SLE

Association with anti rRNP with major CNS disorder in SLE

Psychotic symptoms

Answer 17

Antibodies to P ribosomal proteins

Question 18

Pathogenesis of SLE:

Answer 18

DNA anti DNA immune complexes (IgG3) will deposit in the BM as well as in glomeruli and initiate an inflammatory mechanism (foreign body) that will cause the cell lysis —- repeated deposition, inflammation reaction will contribute to kidney damage

Question 19

Anti SS-A/Ro alone has:

Answer 19

Strongly associated with HLA-DRE 2

Young (

Question 20

Anti SS B/LA antibodies has strong association with:

Answer 20

Sjogren’s syndrome

Question 21

Clinical features of anti KI antibody:

Answer 21

Arthritis
Pericarditis
Pulmonary hypertension

Question 22

True or false. nRNP could not be biochemically isolated from the sm antigen.

Answer 22

True

Question 23

Associated with major CNS disorder in SLE

Psychotic symptoms

No association shown with cognitive impairments or depression

Answer 23

Antibodies to P ribosomal proteins

Question 24

The skin lesion is as follows:

Persistent localized erythema
Adherent scales
Follicular plugging
Telangiectasis
Atrophy

Answer 24

Chronic discoid lupus erythematosus (CDLE)

Question 25

Has a characteristic (+) histone auto antibodies

Answer 25

Drug induced lupus erythematosus

Question 26

Clinical features of:
Arterial and venous thrombosis
Thrombocytopenia
Hemolytic anemia
MISCARRIAGE ( most common)

Answer 26

Antiphospholipid antibodies in SLE (APAS)