Special sense - ear Flashcards

1
Q

Anatomy of the ear

3 parts

A

External ear: pinna, ear canal, tympanic membrane
Middle ear: 3 ossicles, oval and round window, eustachian tube
Internal ear: cochlear, semi-circular canals

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2
Q

Middle ear 3 ossicles

A

Maleus, Incus and Stapes

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3
Q

Hearing and balance

A

-The outer and middle ear are involved with hearing
-The inner ear functions in both hearing and equilibrium
-Receptors for hearing and balance
Respond to separate stimuli
Are activated independently
-Afferent fibres from:
Hearing receptors in cochlear vestibular division
Transmit information from the inner ear in from of action potentials via vestibulocochlear nerve to the brain

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4
Q

The inner ear

2 things

A

Bony Labryinth:
Tortuous channels worming their way through the temporal bone, filled with perilymph
Contains the vestibule, the cochlea and the semicircular canals
Membranous labyrinth:
Series of membranous sacs within the bony labyrinth, filed with potassium-rich fluid

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5
Q

How we perceive sound

A

-The outer ear and external auditory canal act passively to capture the acoustic energy
-Sound waves strike the tympanic membrane causing it to vibrate
-Formation of a perilymph (fluid) wave within the cochlea
-Wave travels the length of the cochlea = displacement of the basilar membrane
-Stereocilia are bent due to a shearing force causing change in resting membrane potential of hair cell
3 structures in the inner ear amplify the sounds

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6
Q

Sound transduction by hair cells

A
  • Oscillations of cochlea membranes cause hair cell sterocilia to bend
  • Sterocilia are different lengths
  • Bend either towards or away from tallest stereocilium (transmit the sounds to the brain by creating the action potential)
  • Signals from hair cells transmitted to brain via cochlear nerve
  • In ends of stereocilia of hair cells are mechanically-gated K+ channels
  • Bending of stereocilia towards tallest stereocilium (kinocilium) opnes mechanically0gates K+ channels in ahir cells
  • Allows K+ to enter cell depolarisation Ca2+ enters cell release of neurotransmitter = action potential
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7
Q

Auditory pathway to the brain

A
  • Vestibulocochlear nerve
  • Spiral ganglion transmit to the brainstem via cranial nerve VIII
  • Synapses on the 2 cochlear nuclei
  • Main pathway involves axons from the ventral cochlear nucleus to the inferior colliculus
  • Travels to and synapse at the medial geniculate body of the thalamus = MGN
  • Finish at the auditory cortex
  • Vestibular nerve (balance) joins the cochlear nerve (hearing) entering the internal acoustic meatus from this point on they are collectively called vestibulocochlear nerve
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8
Q

Deafness = hearing aids

A

3 basic parts
Microphone
Amplifier
Speaker

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9
Q

Vestibular apparatus –> balance

Comprised of

A

Comprides: 3 semicircular canals, 1 utricle, 1 saccule

  • Semicircular canals contain endolymph
  • At base of each semicircular canal is ampulla (jug)
  • Within each ampulla is cupula (cap)
  • Utricle and saccule = linear acceleration
  • Cupula and ampulla = rotational acceleration
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10
Q

Structure of ampulla

A
  • Ampulla sits as base of each semicircular canal
  • Each ampulla has ridge (crista) that extends with cupula = cap into the lumen of fluid filled inside the ampulla
  • Cupula bridges width of ampulla
  • Forms mobile barrier through which endolymph (fluid) cannot circulate
  • Mechanoreceptor hair cells extend out of crista into gelatinous cupula
  • If head it tilted endolymph pushes against hair bundles in cupula
  • Mechanoreceptor hair cells transmit information to vestibulocochlear nerve
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11
Q

Transduction of rotation

A
  • The movement of stereocilia towards or away from Kino cilium causes K+ channels to open or close
  • Causes depolarisation or hyperpolarisation of hair cells, increasing or decreasing Ca2+ concentration within cells
  • End result is increase or decrease in number of action potentials
  • Information is interpreted in the brain
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12
Q

Anatomy of utricle and saccule

A
  • Utricle and saccule detect linear acceleration in same way that semicircular canals that detect rotational acceleration
  • Receptor cells are hair cells with stereocilia that extend into gelatinous layer containing small calcium carbonate crystals
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13
Q

Chemical sense - smell and taste

Chemoreceptors

A

-Respond to chemicals in aqueous solution
-Membrane of sensory neurons becomes depolarised action potentials
-Respond to different classes of chemicals
-Complement each other
-Smell and taste are related
in severe rhinitis loss of specific taste of food

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14
Q

Smell

A
  • Chemoreceptor animals have much better olfactory ability to humans
  • This superior ability is reflected in:
    Greater surface are of nasal cavity lining
    The size of the olfactory region of the brain
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15
Q

Olfactory nerves

A
  • Sensory nerves of smell
  • Run from nasal mucosa to olfactory bulbs
  • Pass though cribriform plate of ethmoid bone
  • Fibres synapse in olfactory bulb
  • Pathway terminates in primary olfactory cortex
  • Purely sensory (olfactory) function
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16
Q

Olfactory anatomy

A

-Smell is difficult to research
-At least 1000 smell genes active in the nose
-Extremely sensitive
-Olfactory epithelium: spans 3cm2 = cilia located on dendrites
Ciliated pseudostratified epithelium
- Nasal cavity also contains pain and temperature receptors (respond to e.g. ammonia, chilli
- Chemical signal gets translated into electrical signal receptor stimulation –chemical changes (G protein cascade) opening/closing of membrane channels

17
Q

Olfactory physiology

A

-Resting membrane potential of olfactory receptors is -55mV
-Continuous impulses arise from these receptors at a rate 1:3/sec
-Stimulation of receptors by odorant substance decreases potential from -55 to -30mV = depolarisation
-Detection of odours at 1 in 10 million molecules
Stronger the odour = increased odour molecules
-Odorant molecules must cross the mucosal layer
-Odorant binding proteins mostly wok via G coupled activation
Triggers depolarisation – leads to action potential
-Smell depends on the pattern of activation of olfactory receptor neurons
-Mitral cells from the olfactory tract, eventually terminate in the olfactory cortex and limbic system

18
Q

Taste - gustation

A
  • Within papillae are taste buds that contain specialised gustatory receptor cells
  • Receptors selectively bind to various chemicals in food
  • Binding of chemical to receptor causes opening/closing of ion channels in cell membrane
  • Causes change in electrical potential of receptor cell membrane
  • Increase in intracellular Ca2+ causes release of transmitter, which signals afferent nerve
  • Most taste buds respond to 2-4 taste qualities
  • Bitter buds are most sensitive (protective)
  • Sugar and salt most pleasurable
  • Taste receptors are fast adaptors
  • Salty taste is simply the perception of sodium ions in the saliva
19
Q

Neural code for tasting

A

In humans, localisation of receptors means that some regions are more sensitive to certain tastes
Several receptors communicate with single afferent system, making perception of test complex

20
Q

Gustatory pathway

A
  • Release of neurotransmitter - AP
  • Facial nerve (anterior 2/3 of tongue) and glossopharyngeal nerve (posterior 1/3 of tongue)
  • Solitary nucleus of medulla (initiate PsNS reflexes to trigger saliva and gastric secretion
  • Thalamus to gustatory cortex of parietal lobes and limbic system