SPECIAL - Non-interpretive skills Flashcards

1
Q

Reactive, retrospective, “policing”; punitive, finger pointing; “who was at fault after a medical error”; old term - QA/QI/QC?

A

Quality assurance (QA)

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2
Q

Both prospective and retrospective; avoids assigning blame; goal is to create systems that prevent medical errors; continuous process - QA/QI/QC?

A

Quality improvement (QI)

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3
Q

System for maintaining a pre-determined level of quality; planning, inspection, corrective action if required - QA/QI/QC?

A

Quality control (QC)

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4
Q

Six improvement aims for the healthcare system

A

from IOM; safety, timeliness, effectiveness, efficiency, equity, patient-centeredness (“STEEEP”)

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5
Q

Quality care is…

A

coordinated, compassionate, innovative

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6
Q

Six core competencies of MOC

A

medical knowledge, interpersonal/communication skills, patient care, professionalism, practice-based learning/improvement, systems-based practice (“MIPPPS”)

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7
Q

Best practices (2)

A

dashboards, benchmarking

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8
Q

Measurement of the quality of an organization’s policies, products, programs, and strategy

A

benchmarking; helps determine improvements, achieve high performance, and improve performance

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9
Q

Visual display of the most important information needed

A

dashboard

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10
Q

PDSA (acronym)

A

Plan-Do-Study-Act

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11
Q

PDSA steps

A

plan = develop hypothesis, do = test hypothesis, study = analyze data, act = draw conclusions and determine next steps

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12
Q

Developing a hypothesis (P, D, S, or A?)

A

Plan

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13
Q

Testing the hypothesis (P, D, S, or A?)

A

Do

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14
Q

Analyze the data (P, D, S, or A?)

A

Study

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15
Q

Draw actionable conclusions and determine next steps (P, D, S, or A?)

A

Act

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16
Q

Improvement is most effective when… (PDSA)

A

multiple PDSA cycles are run in parallel or in rapid succession

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17
Q

Major quality improvement methodologies

A

PDSA, Lean Process Improvement, and Six Sigma

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18
Q

When and who published “To Err Is Human”?

A

IOM, 1999; part of Quality of Health Care in America project

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19
Q

Number of deaths attributable to medical error per year

A

44,000 to 98,000

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20
Q

Percentage of hospitalizations in which adverse events occur

A

3-4%

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21
Q

Percentage of adverse events leading to death

A

7-14%

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22
Q

Failure of a planned action to be completed as intended or use of a wrong plan to achieve an aim

A

medical error; highest risk locations are ER, OR, and ICU

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23
Q

Parent organization of Institute of Medicine

A

National Academy of Sciences (NAS)

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24
Q

Most medical errors were system errors or individual errors?

A

system errors

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25
Q

Factors contributing to medical errors (from IOM report) (4)

A

decentralized nature of healthcare, failure to focus on errors, impediment to identify errors, failure of third-parties to incentivize improving safety

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26
Q

Organization funded by congress in response to IOM report

A

Agency for Healthcare Research and Quality (AHRQ); created in 2000

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27
Q

Purpose of “Never Events” list

A

to serve as a basis of a mandatory reporting system

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28
Q

Discipline which examines how systems work in actual practice with real human beings

A

human factors engineering; attempts to design systems that optimize and minimize risk of error

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29
Q

Standardization of equipment and processes is an axiom of…

A

human factors engineering

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30
Q

Checklists are an example of ________

A

standardization

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31
Q

Organizations that consistently minimize adverse events despite carrying out instrinsically complex and hazardous work

A

high reliability organization (HRO)

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32
Q

Characteristics of a HRO

A

fixation on failure, avoidance of oversimplification, respect of expertise, dedication to resilience, sensitivity to operations (“FARDS”)

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33
Q

Features of a safety culture

A

acknowledgement of high risk nature of activities, blame-free environment, encouragement of collaboration, commitment of resources to address safety concerns

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34
Q

Authority gradients encourage or undermine safety culture

A

undermine

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35
Q

Measurement of Safety Culture

A

surveys of providers at all levels

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36
Q

Examples of Safety Culture surveys

A

Patient Safety Culture Survey and Safety Attitudes Questionnaire (both from AHRQ)

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37
Q

Teamwork systems, administrative walk-arounds, and unit-based systems are associated with improvements in….

A

Safety Culture

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38
Q

Model with focus on addressing systems issues that lead individuals to engage in unsafe behaviors, while maintaining individual accountability

A

Just Culture model

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39
Q

Three manageable behaviors of the Just Culture model

A

Human Errors, At-risk Behaviors, Reckless Behaviors

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40
Q

In a Just Culture model, the response to an error is predicated on the severity of the event or the type of behavior associated with the event

A

type of behavior associated with the adverse event; e.g. refusing to do a timeout even if no patient was harmed would result in punitive action

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41
Q

Response to Human Errors (e.g. slips)

A

Human Errors are consoled

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42
Q

Response to At-risk Behaviors (e.g. shortcuts)

A

At-risk Behaviors are coached

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43
Q

Response to Reckless Behaviors (e.g. ignoring required safety steps)

A

Reckless Behaviors are punished

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44
Q

Human Reliability Curve relates…

A

Human reliability (y-axis) to factor affecting human performance (x-axis); never reaches 100% reliability

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45
Q

Area under Human Reliability Curve

A

Successful operation (by the human)

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46
Q

Area above Human Reliability Curve

A

Human error

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47
Q

Person in an organization who takes ownership of processes and foster creation/maintence of the safety culture

A

safety coach/champion

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48
Q

Primary focus in a safety-report system

A

the patient, the system, and the event

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49
Q

Healthcare worker who is traumatized by or unduly punished for an error or adverse patient event

A

second victim; may exhibit signs similar to PTSD

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50
Q

Two broad categories of radiologist errors + which is more common

A

perceptual errors and cognitive/interpretive errors

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51
Q

Most radiologist errors are cognitive or perceptual?

A

perceptual (60-80%)

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52
Q

Poor lesion conspicuity, reader fatigue, rapid pace of interpretation, phone calls, and satisfaction of search are examples of which type of radiologist error?

A

perceptual errors (missed finding which is present in retrospect)

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53
Q

Error analysis tool used to examine serious adverse events

A

root cause analysis; identifies underlying problem that increases likelihood of errors; avoids focusing on individal mistakes; goal is to eliminate latent errors

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54
Q

Error occurring at the interface between humans and a complex system (in RCA)

A

active errors (how event occurred)

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55
Q

Hidden problems in healthcare systems that contribute to adverse events (in RCA)

A

latent errors (why event occurred)

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56
Q

“Quick fix” in root cause analysis

A

a quick fix may be implemented early in the RCA process to rapidly reduce the risk of a similar error, even though it may not be the definitive solution to a root cause

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57
Q

Accuracy vs. precision - how variable is a test result in ANY given situation?

A

precision

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58
Q

Accuracy vs. precision - how variably does the test result reflect the desired diagnosis?

A

accuracy; (TP + TN) / (TP + FN + FP + TN)

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59
Q

Patient identifiers, patient assessment, informed consent, and medication reconcilation are part of what process?

A

peri-procedural care

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60
Q

Number of patient identifiers that should be used before a procedure

A

2 or more; include patient name, MRN, phone number, DOB, photo ID, last 4 SSN

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61
Q

Example of a piece of information that cannot be used as a patient identifier

A

patient location or room number

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62
Q

Which is not an acceptable source of patient identifiers; the patient, a relative, a guardian, a domestic partner, or a healthcare provider who has previously identified the patient?

A

all are acceptable sources of patient identifiers

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63
Q

Elements of informed consent (5)

A

discussion of procedure, benefits, potential risks, reasonable alternatives, risk of refusing procedure

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64
Q

Six rights of medication administration

A

right patient, right medication, right route, right dose, right time, and right documentation

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65
Q

Pre-procedure verification, procedure site marking, and performing a timeout are components of what?

A

Universal Protocol

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66
Q

Items which must be agreed on during a timeout

A

correct patient identity, correct site, procedure to be performed; completion of the timeout must be documented

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67
Q

Maximum sterile barrier technique

A

for more invasive procedures (e.g. central line); defined by National Quality Measures Clearinghouse; cap, mask, sterile gown, sterile gloves, large sterile sheet, hand hygeine, cutaneous sepsis

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68
Q

Which organizations collaborated on the ‘Practice Parameter for Sedation/Analgesia’?

A

ACR and SIR (Society of Interventional Radiology)

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69
Q

Levels of sedation are defined by whom?

A

Joint Commission and American Society of Anesthesiologists (ASA)

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70
Q

Levels of sedation (4)

A

minimal (anxiolysis), moderate, deep, and general anesthesia

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71
Q

Moderate sedation description

A

patient retains ability to maintain a patent airway and can be aroused by physical/verbal stimulations

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72
Q

ASA class(es) of patients that qualify for moderation sedation

A

class I (normal healthy patient), class II (mild systemic disease); classes III and IV may require additional consideration for sedation

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73
Q

Discharge criteria after use of a sedation reversal agent

A

patient’s level of consciousness and vital signs should return to an acceptable level for at least 2 hours prior to discharge

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74
Q

Who was/is responsible for developing/updating the ACR Guidance Document for Safe MR Practices?

A

Blue Ribbon Panel on MR Safety (which was established by the ACR)

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75
Q

Publically accessible, unrestricted MR zone

A

zone 1

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76
Q

MR zone for greeting patients, obtaining histories, and screening patient

A

zone 2; under supervision of MR personnel

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77
Q

Restricted access MR zone(s)

A

zones 3 and 4

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78
Q

MR zone with physical restriction from entry (door, lock, etc.)

A

zone 3

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79
Q

MR zone containing the MR magnet

A

zone 4

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80
Q

First action in the event of a quench

A

evacuate the room immediately

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81
Q

First action in the event CPR is required (or other medical emergency)

A

remove patient to a magnetically safe location

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82
Q

Type of gas that fills MR magnet room in a quench

A

helium gas (displaces oxygen); same process occurs if a tank bursts or there is a helium leak; oxygen levels in the scanner room must be monitored at all times

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83
Q

When must oxygen levels in the MR scanner room be monitored?

A

at all times

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84
Q

Potentional MR complication of loops of wire, metallic transdermal patches, and large tattoos

A

skin burns; first two should be removed prior to entry, ice pack may need to be applied to area of tattoo during scanning

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85
Q

T/F - the majority of contrast reactions are mild and self-limited

A

true

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86
Q

Overall incidence of contrast reactions with low osmolality media

A

0.2-0.7% (or <1%)

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87
Q

Three goals for contrast administration

A

appropriate for patient and indication, minimize likelihood of contrast reaction, and be prepared to treat a reaction

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88
Q

Greatest risk factor for a contrast reaction

A

history of prior reaction to contrast; assoc. with 5x increased risk

89
Q

Increased risk of contrast reaction with history of shellfish allergy?

A

no

90
Q

Risk factors for a contrast reaction

A

history of prior reaction to contrast > history of allergic reaction not related to contrast (atopy, asthma, major anaphylactic reaction), significant cardiac disease

91
Q

Who gets premedication for contrast?

A

patients at increased risk for an acute contrast reaction

92
Q

Most contrast reactions are due to histamine release or IgE-mediated?

A

histamine release (90%)

93
Q

Preferred premedication regimen - PO or IV?

A

PO; risk of reaction to corticosteroids when administered IV

94
Q

Increased contrast osmolality is associated with increased or decreased likelihood of a contrast reaction?

A

hyperosmolar contrast is assoc. with increased likelihood

95
Q

PO premedication regimens for contrast reaction (2)

A

50mg prednisone PO at 13, 7, and 1 hour before injection + diphenhydramine 1 hour before; or, 32mg methylprednisolone PO at 12 and 2 hours before + diphenhydramine 1 hour before

96
Q

IV predmedication regimen for contrast reaction (in patients unable to take PO)

A

same as prednisone protocol, but with 200mg IV hydrocortisone and IV/IM benedryl

97
Q

Most desirable contrast premedication protocol when scan is desired in less than 4-6 hours

A

40mg methylprenisolone or 200mg hydrocortisone IV q4 hours until contrast is required + 50mg diphenhydramine IV at 1 hour before

98
Q

Premedication has a proven benefit in reducing major or minor contrast reactions, or both?

A

minor contrast reactions; no proof for protection against severe life-threatening reactions

99
Q

IV contrast utilization in patients with thyroid cancer or hyperthyroidism

A

IV contrast should be avoided 4-6 weeks prior to anticipated I-131 treatment (may “block” thyroid uptake of I-131)

100
Q

Contraindications to premedication with steroids

A

diabetes, uncontrolled HTN, TB, systemic fungal infection, PUD, diverticulitis

101
Q

Types of contrast reactions (3)

A

mild, moderate, severe; may be considered allergic-like or physiologic

102
Q

Type of contrast reaction: hypertensive urgency

A

moderate, physiologic; if hypertensive emergency, then severe

103
Q

Type of contrast reaction: vasovagal reaction that requires treatment

A

moderate, physiologic; if treatment is not required, then mild

104
Q

Type of contrast reaction: diffuse urticaria

A

moderate, allergic-like; if focal urticaria, then mild

105
Q

Examples of severe contrast reactions

A

anything that causes dyspnea/stridor, hypoxia, or hypotension; also arrhythmia, seizure, hypertensive emergency

106
Q

Dilution for IM epinephrine

A

1:1,000; ‘M’ in IM for ‘mill-‘ (1/1000th)

107
Q

Dilution for IV epinephrine

A

1:10,000 via slow infusion; IV administration of epinephrine is preferred in severe cases

108
Q

Initial step for managing a contrast reaction

A

monitor vitals/pulse ox/preserve IV access +/- oxygen at 6-10 L/min via face mask

109
Q

Dose limit for epinephrine administration (contrast reaction)

A

repeat doses may be given up to a total of 1 mg; for IM, 0.1 mL = 0.1 mg (1 mL total); for IV, 1 mL = 0.1 mg (10 mL total)

110
Q

Dose limit for atropine administration (contrast reaction)

A

repeat doses may be given up to a total of 3 mg; typical single dose is 0.6 to 1.0 mg IV

111
Q

Hives management flow chart (contrast reaction)

A

usually no treatment; if symptomatic => benadryl; if severe => epi

112
Q

Hypotension (SBP <90 mmHg) management flow chart (contrast reaction)

A

O2 + elevate legs => rapid IVF => if bradycardic give atropine OR if tachycardic give epi => 911

113
Q

Bronchospasm management flow chart (contrast reaction)

A

O2 => inhaled albuterol => epi => 911

114
Q

Laryngeal edema management flow chart (contrast reaction)

A

O2 => epi => 911

115
Q

Hypertensive crisis (SBP >200 mmHg) management flow chart (contrast reaction)

A

O2 => IV labetalol (or SL nitroglycerin) => IV lasix => 911

116
Q

Pulmonary edema management flow chart (contrast reaction)

A

O2 + elevate head => IV lasix => morphine => 911

117
Q

Seizure management flow chart (contrast reaction)

A

O2 => lorazepam => 911

118
Q

Hypoglycemia management flow chart (contrast reaction)

A

O2 => PO glucose (or D50W or IM glucagon) => 911

119
Q

Unresponse/pulseless management flow chart (contrast reaction)

A

911 => CPR + defibrillate + epi

120
Q

By definition, post-contrast AKI (PC-AKI) occurs within _______ hours of contrast administration

A

48 hours; CIN is subset of PC-AKI where the kidney injury is determined to be due to intravascular contrast

121
Q

Arterial or venous administration of contrast material is associated with a greater risk of CIN?

A

arterial

122
Q

Typical clinical course of CIN

A

rise in Cr within 24 hours => peaks at 4 days => returns to baseline within 7-10 days

123
Q

Permanent renal dysfunction related to CIN is rare or common?

A

rare

124
Q

Two main risk factors for developing CIN for which there is consensus

A

pre-existing renal insufficiency and AKI

125
Q

Most proven strategy for prevention of CIN in at risk patients

A

IV hydration with 0.9NS or LR; 100 mL/hour for 6-12 hours before and 4-12 hours after

126
Q

Risk of CIN in patients with anuric end-stage renal disease

A

no risk of CIN; thus no need for urgent dialysis after IV contrast

127
Q

Patients whom the ACR recommends obtaining a serum Cr prior to contrast administration

A

age >60, h/o renal disease, hypertension, diabetes, or use of metformin; if patient is stable, Cr value within 30 days is acceptable; same criteria are used for obtaining a GFR prior to gad administration (minus metformin)

128
Q

Low or high osmolality contrast agents are preferred in patients with renal insufficiency?

A

low osmolality contrast (less nephrotoxic); high osmolality contrast is not currently used in US

129
Q

Majority of gadolinium-based contrast reactions are mild or severe?

A

mild; e.g. nausea/vomiting, itching, warmth, paresthesias; allergic-like and anaphylactic reactions are rare

130
Q

Risk factors for gadolinium-based contrast media (4)

A

prior reaction to GBCM (8x), allergy to iodinated contrast, asthma, other non-contrast-related allergies

131
Q

Pathway of GBCM in maternal-fetal circulation

A

maternal circulation => cross placenta => fetal circulation => filtered by fetal kidneys => excreted into amniotic fluid => stays for prolonged time and may dissociate from chelate

132
Q

Gad is an absolute or relative contraindication in pregnancy

A

relative contraindication

133
Q

Risk factors for developing NSF (2)

A

AKI or severe CKD (1-7% risk in stage 4/5 CKD)

134
Q

GFR threshold above which no special precautions for gad are required

A

GFR >40

135
Q

Patients in whom GBCM administration should be avoided or severely limited

A

dialysis patient, GFR <30, or AKI

136
Q

Effect of flow rate on contrast extravasation

A

higher flow rate (power injection) assoc. with increased severity of the extravasation, but NOT increased frequency

137
Q

Risk factors for contrast extravasation related to venous access (3)

A

distal access sites (hand/wrist/foot/ankle), line older than 24 hours, multiple punctures into same vein

138
Q

Major risk factors for development of compartment syndrome following contrast extravasation (2)

A

volume of extravasated contrast, capacity of site of extravasation

139
Q

Severe complications of contrast extravasation

A

compartment syndrome, skin ulceration/tissue necrosis

140
Q

Indications for surgical consultation after contrast extravasation

A

progressive pain/swelling, decreased capillary refill, sensory changes, skin ulceration/blistering

141
Q

Three fundamental principles of medical professionalism

A

primacy of patient welfare (serve the interest of the patient; altruism), patient autonomy, social justice

142
Q

Fair distribution of healthcare resources and elimination of discrimination refers to what principle?

A

social justice

143
Q

First 5 “commitments” of the Physician Charter on Medical Professionalism

A

Professional competence, Honesty with patients, Patient confidentiality, Maintain appropriate patient relations, Improving QOC

144
Q

Second 5 “commitments” of the Physician Charter on Medical Professionalism

A

Improving access to care, Just distribution of finite resources, Scientific knowledge, Maintaining trust by managing conflicts of interest, Professional responsibilities

145
Q

PHI (acronym)

A

protected health information; information which identifies patient or could be used to reasonably identify patient

146
Q

Situations in which PHI can be transmitted without individual authorization (5)

A

at individual’s request; in the course of treatment; for payment; for operations involving quality/compliance/fraud; when required by law

147
Q

Standard communication in radiology refers to what?

A

creation and delivery of written reports

148
Q

Medically significant changes to a preliminary report should be…

A

communicated directly to the referring physician; not required for minor changes

149
Q

When viewed in an electronic system an addendum should appear before or after the original report?

A

before; a final report cannot be edited, can only be addended

150
Q

Level of non-standard communications: new or unexpected findings that are life threatening or require an immediate change in management

A

level 1; requires direct contact between radiologist and referring physician (or other responsible provider); communication must be documented

151
Q

Definition of a ‘critical result’

A

any result or finding that may be considered life threatening or that could result in severe morbidity and require urgent or emergent clinical attention

152
Q

Accredited facilities are required to define critical tests and critcal results, and monitor reporting of those results by whom?

A

Joint Commission

153
Q

Time requirement for level 1 communication

A

within 30-60 minutes of time the observation is made

154
Q

Relationship between critical results and level 1 communication

A

all critical results require level 1 communication, but not all level 1 communication is a critical result

155
Q

Do critical tests require rapid communication?

A

yes, regardless of what the study shows; e.g. negative PE study

156
Q

Level of non-standard communications: new or unexpected findings that could result in mortality or significant morbidity if not treated urgently (within 2-3 days)

A

level 2; call service or an associate may be used to communicate results

157
Q

Time requirement for level 2 communication

A

within 6-12 hours

158
Q

Level of non-standard communications: new or unexpected findings that could result in significant morbidity if not treated appropriately, but are not immediately life-threatening

A

level 3; these findings are often communicated electronically

159
Q

Time requirement for level 3 communication

A

not time sensitive

160
Q

Documentation for non-standard communications requirements

A

date and time of communication, name of person reporting findings, name of person receiving findings, +/- time observation was made (for level 1 findings)

161
Q

“Curbside consults” and “wet reads” are examples of what?

A

informal communications; should still be documented in some form by radiologist

162
Q

Percentage of abnormal radiographic findings that are missed

A

30%

163
Q

Most common cause of malpractice suits against radiologists

A

errors in diagnosis; further categorized as failure in detection, interpretation, communication of results, or suggesting appropriate follow-up test

164
Q

Radiologist diagnostic errors can be classified as… (2)

A

cognitive errors (e.g. missed findings) or systemic errors (e.g. failure of communication)

165
Q

Meaning of ‘radiologic errors’

A

combination of cognitive and systemic errors; e.g. missed findings due to long shift length

166
Q

Body designated to review and monitor research involving human subjects

A

IRB; required to register with DHHS

167
Q

Requirement for all human subjects participatring in a research study

A

must give informed consent

168
Q

CPT code (acronym)

A

current procedural terminology

169
Q

What body maintains CPT codes?

A

American Medical Association (AMA)

170
Q

ICD (acronym)

A

international classification of disease; formulated during a conference sponsored by WHO

171
Q

Concordance between CPT and ICD codes is termed what?

A

medical necessity

172
Q

Combining individual components of a complicated procedure for billing purposes is called what?

A

bundling

173
Q

RVU (acronym)

A

relative value unit

174
Q

What is meant by ‘meaningful use’?

A

basically using EMR technology to improve outcomes, communication, transparency, and efficiency

175
Q

Type of data: data values fall in categories without any inherent order

A

nominal; e.g. race, gender, subspecialty

176
Q

Type of data: data possess some inherent order but the size of the interval between categories is not quantifiable

A

ordinal; e.g. BI-RADS, assigning excellent/very good/good/fair ratings

177
Q

Type of data: data possess inherent order and the interval between successive values is equal

A

interval; can be averaged; may be continuous or discrete; e.g. temperature in celsius (continuous) or number of seizures per month (ordered discrete)

178
Q

Type of data: similar to interval data, but measures reflect a ratio between a continuous quantity and a unit magnitude of the same kind

A

ratio; e.g. birth weight in kg, percent vessel stenosis

179
Q

Type of variable: basic units are not quantifiable

A

categorical; may be nominal or ordinal; e.g. race, gender

180
Q

Type of variable: can take values within a given interval and generally have higher information content

A

continuous or ordered discrete; e.g. time, age, blood pressure

181
Q

Which measurement is more affected by outliers - mean or median?

A

mean

182
Q

Mode is most often used for these variable types

A

categorical or nominal; e.g. race, gender

183
Q

Amount of spread around the mean of data set

A

variance

184
Q

Average distance of observations from the mean

A

standard deviation; std dev = sqrt(variance)

185
Q

Meaning of n-th percentile

A

value at which n percent of the data lie below

186
Q

Type I error

A

reject the null hypothesis when the null is true = FALSE POSITIVE; α is the probability of type I error

187
Q

Type II error

A

fail to reject the null hypothesis when the null is false = FALSE NEGATIVE; β is the probability of type II error

188
Q

Meaning of p-value

A

probability that the observed effect was merely chance

189
Q

p-value greater than alpha

A

non-signficant result; does not prove null hypothesis, but cannot eliminate it

190
Q

p-value less than alpha

A

statistically significant result

191
Q

Range of reasonable values intended to contain the parameter of interest

A

confidence interval; desired degree of confidence is most often 95%

192
Q

Relationship between CI and precision of an estimate

A

wide CI = less precise; narrow CI = more precise

193
Q

Sensitivity (definition)

A

proportion with disease who test positive; TP/(TP+FN)

194
Q

Specificity (definition)

A

proportion with no disease who test negative; TN/(TN+FP)

195
Q

SNOUT mnemonic

A

high SeNsitivity test to rule OUT the disease; negative result suggests a low chance of having disease

196
Q

SPIN mnemonic

A

high SPecificity test to rule IN disease; positive result suggests a high chance of having disease

197
Q

Power

A

power = 1 - β, where β is the probability of making a type II error

198
Q

Tests with high ________ have low type I error rates

A

high specificity; α = 1 - specificity

199
Q

Tests with high ________ have low type II error rates

A

high sensitivity; β = 1 - sensitivity

200
Q

Good screening tests have high _________

A

high sensitivity

201
Q

Good confirmatory tests have high _________

A

high specificity

202
Q

Studies used to estimate PPV and NPV should include what?

A

prevalence of disease in the study population; PPV and NPV are influenced by prevalence

203
Q

What should be done if prevalence of disease in the study population does not match the prevalence in the general population?

A

likelihood ratios should be used instead of PPV and NPV; e.g. case control studies do not yield prevalence and thus cannot be used to estimate PPV and NPV

204
Q

ROC (acronym) - as in ROC curve

A

receiver operating characteristic

205
Q

ROC curve axes

A

x-axis = false positive rate (or 1 - specificity); y-axis = true positive rate (or sensitivity)

206
Q

How is an ROC curve generated?

A

plotting sensitivity and specificity values for each “cut-point” along the curve

207
Q

What does area under the ROC represent?

A

test accuracy; see http://gim.unmc.edu/dxtests/roccomp.jpg

208
Q

Bias: when comparisons are made between subjects that differ in ways not being studied

A

selection bias; may reduce generalizability of study results to broader population

209
Q

Bias: important subgroups are missing from the sample

A

spectrum bias (type of selection bias)

210
Q

Bias: patients with positive or negative test are preferentially referred for the gold standard test

A

verification or referral bias (type of selection bias); sensitivity and specificity are based only on those who underwent the gold standard test

211
Q

Bias: members of a population are more or less likely to be included than others

A

sampling bias (type of selection bias)

212
Q

Bias: study groups are measured differently

A

measurement bias

213
Q

Bias: tests performed or interpreted without blinding

A

review bias (type of measurement bias)

214
Q

Bias: two factors are associated and the effect of one is distorted by the effect of the other

A

confounding bias

215
Q

Bias: study volunteers tend to be healthy and have better outcomes

A

screening/compliance bias

216
Q

Bias: period of time between detection via screening and when detection would have occurred due to symptoms

A

lead-time bias; patients appear to live longer because they’re detected earlier, but still die at the same time (earlier treatment is no more effective)

217
Q

What should you compare to avoid lead-time bias?

A

age-specific mortality rates

218
Q

Bias: screening tends to find slow-growing tumors, which inherently have a better prognosis

A

length-time bias; this is because fast-growing tumors are more likely to be symptomatic and present outside of screening

219
Q

Bias: screening detects disease that will never become clinically important in a patient’s lifetime

A

overdiagnosis