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Y2 LCRS Neuro Fwong > Sound Conduction and Transduction > Flashcards

Sound Conduction and Transduction Flashcards

1
Q

What scale is used to measure how loud a sound is?

A

Decibels (logarithmic scale)

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2
Q

What is the audible range for humans in terms of frequency?

A

20-20,000 Hz

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3
Q

What is the name given to the wing shaped flap skin and cartilage that makes up the outer ear?

A

Pinna

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4
Q

Describe the shape of the outer ear and its importance.

A

It is conical – starts off wide at the external auditory meatus and narrows to the tympanic membrane
This focuses the noise and increases the pressure on the tympanic membrane

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5
Q

Is the tympanic cavity fluid-filled or air-filled?

A

Air-filled

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6
Q

State 2 ways in which the ossicles increase the pressure of vibration of the tympanic membrane.

A

Focussing the vibrations from the large surface area of the tympanic membrane to the small surface area of the oval window – this decrease in surface area means that the pressure is increased
The incus has a flexible joint with the stapes, such that the ossicles use leverage to increase the force on the oval window
This amplifies the sound by 30 dB

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7
Q

What is the point of the middle ear? Why isn’t the tympanic membrane continuous with the cochlea?

A

The cochlea contains fluid, in which you are trying to induce a pressurewave
If the tympanic membrane was continuous with the cochlea, you would go straight from air to fluid and 99% of the energy will bounce back due to impedance
Sound waves require more energy to travel through fluid than air so the increase in pressure of vibration allowed by the ossicles is crucial for this conduction

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8
Q

What 2 muscles are involved in making sure that the ossicles aren’t damaged by excessive vibration due to loud noise?

A

Tensor Tympani (V3): The tensor tympani acts to dampen the noise produced by chewing. When tensed, the muscle pulls the MALLEUS medially, tensing the tympanic membrane and damping vibration in the ear ossicles and thereby reducing the perceived amplitude of sounds.

Stapedius (VII)- prevents excess movement of the STAPES, helping to control the amplitude of sound waves from the general external environment to the inner ear

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9
Q

What is the name given to this reflex?

A

Auditory reflex

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10
Q

What is the latency period (time between the stimulus and a reflex response) of this reflex?

A

50-100 ms

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11
Q

What is hyperacusis?

A

Heightened sensitivity to sound, with aversive or pained reactions to normal environmental sounds.– can occur in conditions that lead to flaccid paralysis of the auditory reflex muscles (e.g. Bell’s Palsy - stapedius is innervated by facial nerve)

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12
Q

Which test is used to determine the site of damage to the auditory system, that is causing hearing loss?

A

Weber Test

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13
Q

What are the 2 specialised membranes of the cochlea?

A

Oval Window

Round Window

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14
Q

What are the three compartments of the cochlea in the inner ear?

A

Scala Vestibuli
Scala Media
Scala Tympani

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15
Q

Which types of fluid do each compartment contain?

A

Scala Vestibuli + Scala Tympani = perilymph

Scala Media = endolymph

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16
Q

What structure connects the two perilymph compartments?

A

Helicotrema

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17
Q

Describe how the cochlea functions.

A

The vibration of the tympanic membrane is conducted and amplified to a vibration of the oval window by the footplate of the stapes.
This vibration induces a pressure wave in the perilymph in the scala vestibuli.
This vibrates the endolymph in the scala media leading to vibration of the basilar membrane.
The round window vibrates as well to equalise the pressure in the cochlea. (since perilymph fluid is mostly water which is incompressible, and so the pressure ‘inserted’ at the oval window needs to be relieved at the round window via vibration as well)

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18
Q

Describe the difference in sensitivity of different parts of the basilar membrane.

A

Higher frequency sounds = base

Lower frequency sounds = apex

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19
Q

What is the Organ of Corti?

A

The sense organ of the cochlea, which converts sound signals into nerve impulses that are transmitted to the brain via the cochlear nerve

20
Q

Where is the Organ of Corti found?

A

It lies on top of the basilar membrane and beneath the tectorial membrane, this is all within the Scala Media

21
Q

What are the two types of cell in the organ of corti?

A

Inner and outer hair cells

22
Q

Describe the features and function of inner hair cells.

A

Found on their own
Not in contact with the tectorial membrane
Send impulses to the brain
They have stereocilia that move in response to the movement of endolymph in the scala media
Roughly 3500 in the body

23
Q

Describe the features and function of outer hair cells.

A

Found in groups of three
They are in contact with the tectorial membrane
They receive input from the brain
Electromotile so can expand and contract to amplify the amount of vibration (this is the basis of the cochlear amplifier)
Damage can result in sensorineural hearing loss
Roughly 20,000 in the body

24
Q

Which fluid of the cochlea does the stereocilia of the hair cells project into?

A

Endolymph, hence movement of endolymph in the scala media will trigger movement of stereocilia on the hair cells

25
Q

What internally generated sounds are the outer hair cells responsible for?

A

Otoacoustic emissions
These are sounds made by the cochlea and can be measured using microphones. They are measured in newborn babies to see if they have hearing problems. This is partly because otoacoustic emissions is closely associated to the cochlear amplifer (the cochlea can amplify the intensity of the sound that you hear and hence make it more audible)

26
Q

What are stereocilia connected by?

A

Tip links

27
Q

What bony conical structure is found at the middle of the cochlea?

A

Modiolus

28
Q

Describe what happens when the basilar membrane is displaced upwards.

A 
Depolarisation  
Upward displacement moves the stereocilia away from the modiolus  
K+ channels open 
K+ enters from the endolymph 
Hair cells depolarises
29
Q

Describe what happens when the basilar membrane is displaced downwards.

A

Hyperpolarisation
Stereocilia move towards the modiolus
K+ channels close and hair cells hyperpolarises

30
Q

Describe the difference in K+ and Na+ concentration in the different compartments of the cochlea.

A

Scala Media = High K+ and Low Na+
Scala Tympani = High Na+ and Low K+
NOTE: stria vascularis maintains this concentration

31
Q

Describe the auditory pathway from the cochlea to the primary auditory cortex.

A

Spiral ganglion -> cochlear nuclei -> superior olive -> inferior colliculus -> medial geniculate nucleus -> primary auditory cortex

32
Q

Up to what point is the auditory pathway from one ear ipsilateral?

A

Cochlear nuclei

Beyond this point there is bilateral representation

33
Q

The inferior colliculus receives input from both cochlea. What is the inferior colliculus responsible for?

What is the role of the superior colliculius?

A

IC: All ascending auditory pathways converge. Eg different sound frequencies converge
Reflex associations – turning your head towards loud noise

SC: Where auditory and visual pathways merge- also important in reflexes involving sound and vision eg turning your head and looking towards the direction of a loud noise

34
Q

Describe a phenomenon that is involved in sharpening the signal coming from the cochlea.

A

Lateral inhibition

35
Q

To which parts of the CNS do collaterals from the auditory pathway go?

A

Reticular formation

Cerebellum

36
Q

In which lobe is the primary auditory cortex?

A

Temporal

37
Q

What is the secondary auditory cortex responsible for?

A

Responding to sounds coming off/on

Responding to the duration of sound

38
Q

What is the name given to the axons that project from the medial geniculate nucleus to the primary auditory cortex?

A

Acoustic radiations (they travel via the internal capsule)

NB optic radiations from the visual pathway travel from lateral geniculate nucleus to the primary visual cortex

39
Q

How do you localise short sound burst?

A

Interaural time delay

40
Q

How do you localise continuous sound?

A

Interaural intensity/ level difference

difference in loudness and frequency distribution between the two ears. (intensity of sound is dependent on frequency and amplitude of the sound wave)

41
Q

What is conductive hearing loss?

A

Any problem at places before the INNER EAR. Involved in conducting the sound waves anywhere along the route through the outer ear, tympanic membrane (eardrum), or middle ear (ossicles).
eg When diseases of the middle ear damage the ossicles or stiffen theirjoints so that the amplification system is eliminated – results in conductive hearing loss

42
Q

What is sensorineural hearing loss and what can it be caused by?

A

When the cochlea (ie the inner ear) or cochlear nerve get damaged, the signal transmitted to the primary auditory cortex is reduced or lost
It can be caused by acoustic schwannoma (tumour of the cochlear nerve) or cerebellar tumours expanding and putting pressure on thecochlear nerve

43
Q

What is the term used to describe loss of hearing due to the death of hair cells in normal ageing?

A

Presbyacusis
presby= old/aging
acusis= hearing

44
Q

Name 2 types of second order neurons found in the cochlear nucleus

A

T- Stellate cells
Bushy cells
These are both neurons in the cochlear nucleus. First order bipolar neurons of the cochlear nerve (part of CNVIII) will synapse with these neurons. They will then project to eg the superior olivary complex (this is all part of the auditory sensory pathway)

45
Q

explain frequency, pitch, intensity, volume

A

Frequency: no of waves per second, measured in Hz
Pitch: Higher frequency = higher pitch.
Sound intensity: units is W/m2. Watt= joules/second so intensity = J/s/m2 so think of it as the amount of energy per second that passes through 1 square metre of space
Volume: Sound intensity is perceived as sound volume. Higher intensity = higher volume

Y2 LCRS Neuro Fwong (22 decks)

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