Sosnowski Acute and Chronic Inflammation

Question 1

marker for selectins

Answer 1

CD34

Question 2

2 different types of leukocyte adhesion molecules

Answer 2

selectins and integrins

Question 3

type of integrin that pulls neutrophil through endothelium

Answer 3

PECAM-1

Question 4

this receptor along with death toll-like receptor bind to sugar on microbe and bring it into cell and kill it

Answer 4

CD14

Question 5

this receptor binds to sugar on microbe and bring it into cell and kills it

Answer 5

mannose receptor

Question 6

process of how a microbe gets degraded: 4 basic steps

Answer 6

microbe attaches to receptor
endocytosis into cell
phagosome and lysosome combine
destruction of microbe

Question 7

best killing component in cells; secretes H2O2

Answer 7

MPO (myeloperoxidase)

Question 8

presents with candida albicans infections; caused by enzyme deficiency and environment

Answer 8

MPO deficiency

Question 9

important in the ability of immune system to clear microbes

Answer 9

C3 (and its cleavage)

Question 10

deals with inflammation (chemokines); leukocytes to destroy microbes

Answer 10

C3a

Question 11

deals with phagocytosis through opsinin coat

Answer 11

C3b

Question 12

forms MAC (membrane attack complex) and causes lysis of microbe

Answer 12

C3b

Question 13

serous (deals with plasma) inflammation example

Answer 13

blister

Question 14

purulent inflammation example

Answer 14

acne

Question 15

acute inflammation can lead to what 2 things

Answer 15

chronic and then fibrosis inflammation

Question 16

this syndrome results from impaired adhesion and migration of leukocyte through endothelium

Answer 16

Polymorphonuclear leukocyte dysfunction syndrome

Question 17

2 main things chronic inflammation causes

Answer 17

atherosclerosis
arthritis

Question 18

marker for macrophages

Answer 18

CD68

Question 19

marker for langerhan’s cells (presents microbe to lymph node)

Answer 19

CD1

Question 20

disease that arises from macrophages not being able to get rid of microbe; so they recruit leukocytes(lymphocytes)

Answer 20

chronic granulomatous disease

Question 21

large sphere where macrophages are on the inside and lymphocytes (a type of leukocytes) are on the outside

Answer 21

granuloma

Question 22

deals with antigens and process for anaphylaxis

Answer 22

Type I hypersensitivity disease

Question 23

deals with antibodies; binds to neuromuscular junction

Answer 23

Type II hypersensitivity disease

Question 24

deals with antigen-antibody complexes

Answer 24

Type III hypersensitivity disease

Question 25

deals with whole cells destroying each other

Answer 25

Type IV hypersensitivity disease