Drugs: Protein Kinase Inhibitors

Question 1

drugs ending in -nib inhibit

Answer 1

protein kinase

Question 2

Imatinib

Answer 2

targets BCR-ABL
inhibits tyrosine kinase

Question 3

BCR-ABL gene is associated with 2 things:

Answer 3

1. leukemia
2. philadelphia chromosome (9 to 22)

Question 4

Erlotinib
Gefitinib

[E and G]

Answer 4

inhibition of tyrosine kinase domain of EGFR

Question 5

these 2 growth factors promote tumor angiogenesis (formation of new blood vessels)

Answer 5

VEGF and PDGF

Question 6

Dabrafenib

Answer 6

VEGF/PDGF receptor blocker
Ras/MEK inhibitor
blocks MAPK pathway