Somatic recombination

Question 1

Three developments

Answer 1

Somatic recombination;

Hypermutation;

Class switching

Question 2

What is somatic recombination

Answer 2

DNA rearrangement;

DNA sequences are initially separated from one another;

Brought tgt by enzymatic removal of intervening seq;

Following rejoining of seq

Question 3

Somatic recombination occurs in?

Answer 3

Developing B cells in bone narrow

Question 4

lg heavy chain gene locus involves?

Answer 4

Selection of one V, D, J segment to form a single VDJ exon;

Which codes for variable region of heavy chain

Question 5

How is specific Vh forms?

Answer 5

Transcription;

pre-mRNA undergoes RNA splicing;

VDJ exon and C segment joined;

mature mRNA codes for a heavy chain has a specific Vh

Question 6

lg light chain gene locus involves?

Answer 6

Selection of one V, J gene to form a single VJ exon;

Codes for VL

Question 7

Immature B cell is form when?

Answer 7

Successful VDJ and VJ arrangement;

Expression of lgM on CSM