Solute Transport: Reabsorption and Secretion

Question 1

Examples of substances that have no net tubular modification. How is the filtered load respect excretion rate?

Answer 1

• inulin, mannitol

- filtered load=excretion rate

Question 2

What is the result that in pregnancy the elevation in cardiac output leads an elevation of GFR and then a high filtered load which decrease the TM of the SGLT2?

Answer 2

Glucosuria at lower plasma glucose levels

- ⬆️ risk for urinary tract infections

Question 3

Compounds that competes for the carriers (nonspecific organic anion transporter [OAT]) with PAH?

Answer 3

Penicillin, furosemide, acetazolamide, salicylate

*for this reason ⬆️ of one ion (-) the secretion and clearance of the others

Question 4

What drugs participate in a transport secretory system for many organic cations which transporter is not specific? What happen if you give two do them simultaneously?

Answer 4

• atropine, morphine, procainamide, cimetidine, amiloride

- ⬆️ [plasma] of both higher than given alone (⬆️ risk side effects)