Posterior Pituitary Flashcards

1
Q

What is the impact of hypokalemia, hypercalcemia and lithium in the behavior of the ADH on the kidney?

A
  • ⬇️ ADH effectiveness on principal cells at CD

* nephrogenic diabetes insipidus

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2
Q

How do you make differential diagnosis of nephrogenic vs central diabetes insipidus?

A

Following Water deprivation and give desmopreessin, plasma levels ADH

  • central: improve urine Os, ADH ⬆️
  • nephrogenic: not improve urine Osm, ADH ⬇️
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3
Q

How do you expect the plasma and urinary osmolality in SIADH?

A

Urinary osmolality >100 (high) + hyponatremia ▶️ SIADH

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4
Q

Cause of central pontine myelinolysis

A

Fast correction of Na with 3% hypertonic saline a chronically hyponatremia

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