Growth, Growth Hormone and Puberty Flashcards
1
Q
What is the Laron syndrome? Treatment?
A
- tissue resistant to GH (⬆️ GH, ⬇️ IGF-1)
- mercasermin (synthetic IGF)
2
Q
What differentiate the growth hormone of the others counter regulatory hormones?
A
GH ⬆️ protein synthesis (because ⬆️ synthesis of IGF ▶️ uses insulin like receptor)
3
Q
Major anabolic effect of IGF-I
A
⬆️ synthesis of cartilage (chondrogenesis) in epiphyseal plates of long bones ▶️ ⬆️ bone length
4
Q
What stimuli is representative for the secretion of GH, besides those that stimulate all stress hormones (including GH)?
A
Deep sleep
*main secretion of GH at night, III, IV No REM stages
5
Q
Diagnosis acromegaly
A
- ⬆️ IGF-I level
- failure to suppress GH/IGF after oral glucose
- MRI with lesion at pituitary
6
Q
Removal an over-producing adenoma of GH is first treatment in acromegaly, and often of almost all endocrinology, except
A
Prolactinoma
