Ionic Equilibrium and Resting Membrane Potential

Question 1

What is the importance of the ungated channels?

Answer 1

Determines the membrane potential at resting

Question 3

Which are the endogenous ligands of the NMDA receptor?

Answer 3

Glutamate and Aspartate

Question 4

What ions does the NMDA receptor allow to flow? And their most important functions?

Answer 4

• Is non-selective channel (Na, K, Ca can flux)

- memory (long-term potentiation) and pain (CNS)

Question 5

What drug can target the NMDA receptor?

Answer 5

Ketamine

Question 6

What ion have a high conductance in resting potential membrane?

Answer 6

• potassium

- ⬆️ leak channels

Question 7

Which are the functions of the Na/K ATPase?

Answer 7

• helps to maintain negative charge inside cell

- volume regulation of excitable tissue

Question 8

What is the ion in that changing its extracellular concentration can affect the resting potential membrane of a cell? Why?

Answer 8

• potassium

- because it’s high conductance at resting

Question 9

What type of channel is the exception to the rule about the mechanism?

Answer 9

Lingand/voltage gated channel