Solid tumors

Question 1

Synovial sarcoma is characterized by the translocation…

Answer 1

t(X;18)(p11;q11)

Question 2

t(11;22)(q24;q12) is characteristic of …

Answer 2

Ewing sarcoma

Question 3

t(12;22) is unique to which solid tumor?

Answer 3

Clear cell sarcoma (i.e. malignant melanoma of the soft parts)

Question 4

Wilm’s tumor (renal cancer) abnormality

Answer 4

del(11p)

Question 5

The most frequent type of chromosomal abnormality in neurogenic tumors is…

Answer 5

gains and losses of whole chromosomes

Question 6

Myxoid liposarcoma is characterized by a highly consistent abnormality ___ in 90% of cases

Answer 6

t(12;16)(q13;p11)

Question 7

Clear cell sarcoma is characterized by which cytogenetic abnormality?

Answer 7

t(12;22)(q13;q12)

Question 8

Mesenchymal tumors are characterized by which type of abnormality?

Answer 8

Reciprocal translocations

Question 9

Epithelial tumors are characterized by which type of abnormality?

Answer 9

Deletions of specific bands or regions

Question 10

Neurogenic tumors are characterized by which type of abnormality?

Answer 10

Numerical changes

Question 11

Germ cell tumors are associated with which abnormality?

Answer 11

i(12)(p10)

Question 12

Most common abnormality in Small Cell Lung Cancer?

Answer 12

3p deletion

Question 13

i(6p) is associated with…

Answer 13

Retinoblastoma