Hematologic Malignancies

Question 1

Abnormality characteristic of acute promyelocytic leukemia APL

Answer 1

t(15;17)

Question 2

Abnormality is considered clonal if…

Answer 2

2+ cells have the same structural abnormality, 2+ cells have the same gain, 3+ have the same loss, 1+ normal cells

Question 3

t(8;14)(q24.1;q32) is the most common abnormality associated with…

Answer 3

Burkitt’s Lymphoma (aggressive B-cell neoplasm)

Question 4

Burkitt’s lymphoma is characterized by rearrangements involving …

Answer 4

the CMYC gene oncogene (8q24)

Question 5

the IGH gene is located at

Answer 5

14q32

Question 6

t(14;18)(q32;q21) is found in 70-90% of

Answer 6

follicular lymphomas (BCL2 and IGH)

Question 7

BCL2 oncogene is located at

Answer 7

18q21

Question 8

t(3;14)(q27;q32) is most often associated with

Answer 8

diffuse large cell lymphoma

Question 9

t(3;14)(q27;q32) involves which genes?

Answer 9

BCL6 (3q) and IGH (14q)

Question 10

Mantle cell Lymphoma is characterized by which abnormality?

Answer 10

t(11;14)(q13;q32) CCND1 and IGH

Question 11

which gene is located at 11q13?

Answer 11

CCND1 (aka BCL1)

Question 12

IGH is located where?

Answer 12

14q32

Question 13

Which translocation is specific for MALT lymphomas?

Answer 13

t(11;18)(q21;q21) forms API2-MALT1 fusion gene on der(11)

Question 14

14q11 rearrangements result in…

Answer 14

T cell lymphomas

Question 15

Where is cMYC located?

Answer 15

8q24

Question 16

2 subgroups of NHL and which is more common

Answer 16

B and T cell lymphoma (B more common)

Question 17

List some recurrent abnormalities in AML

Answer 17

t(8;21), inv(16), t(15;17) APL, t(9;11), inv(3)

Question 18

ALL: good prognosis

Answer 18

hyperdiploid (>50 chromosomes)

Question 19

t(12;21)(p13;q22) occurs in 20-25% of…

Answer 19

pediatric ALL

Question 20

Ewing Sarcoma abnormality

Answer 20

t(11;22)(q24;q12)