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Manufacturing > Solid: Tableting & Coating > Flashcards

Solid: Tableting & Coating Flashcards

1
Q

Compression of tablet components within a die cavity by pressure exerted by movement of 2 punches

A

Tableting

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2
Q

Tableting Machine

A

Single Punch Press (Eccentric Press) - 200 tab/min
Multistation Press (Rotary Press) - >10,000tab/min

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3
Q

Parts of Tableting Machine

A

Hopper
Feed Shoe/Feed Frame
Die
Punches (Upper, Lower)
Cam Tracks

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4
Q

Part of tableting machine that holds the material

A

Hopper

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5
Q

Part of tableting machine that transfer materials from hopper to die

A

Feed Shoe or Feed Frame

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6
Q

Part of tableting machine that defines the size and shape

A

Die

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7
Q

Part of tableting machine that compress the materials within the die

A

Punches

Upper Punch: Compression
Lower Punch: Ejection

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8
Q

Part of tableting machine that guides the movement of punches

A

Cam Tracks

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9
Q

Flowability problems

A

Arching/Bridging – arch-shaped obstruction forms above hopper outlet

Rat-Holing – discharge takes place only above hopper outlets

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10
Q

Forms a stable, compact mass when pressure is applied

A

Compressibility

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11
Q

Reserved for a small group of crystalline chemicals having the physical characteristics required for the formation of good tablet

A

Direct Compression

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12
Q

Examples of Direct Compression

A

Potassium salts
Ammonium Salts
Methenamine
Sodium Salts

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13
Q

Diluents used in Direct Compression

A

MCC
Spray Dried Lactose (Anhydrous)

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14
Q

Application of coating material to a moving bed of solids with concurrent use of heated air to facilitate evaporation of the solvent

A

Coating

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15
Q

Types of Coating Processes

A
  1. Sugar Coating
  2. Film Coating
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16
Q

Equipment used in coating

A

A. Standard Coating Pan – consists of a rotating circular metal pan with ducts
Methods:
o Pan Pouring – for viscous solutions; problem: surface erosion
o Pan Spraying – increases efficiency

B. Perforated Coating Pan – exhaustion is through the perforations
C. Fluidized Bed Coater

17
Q

Steps in Sugar Coating

A

Sealing
Subcoating
Smoothing
Color coating
Polishing

18
Q

Water proofing; strengthens tablet core by preventing water penetration

A

Sealing

19
Q

Agents used in Sealing of Sugar Coat

A

Shellac
Cellulose acetate phthalate (CAP)
Polyvinyl acetate phthalate (PVAP)

20
Q

Round off tablet, Addition of 3 to 5 subcoats of sugar-based syrups, increase in 50 - 100% weight

A

Subcoating

21
Q

Application of simple syrup solution (60-70%), used to obtain smooth surface

A

Smoothing

22
Q

Application of multiple syrup solutions containing appropriate colorant, most critical

A

Color coating

23
Q

Three phases of Color Coating

A

Grossing – develops color
Heavy Syruping – builds up color
Regular Syruping – final color

24
Q

Addition of waxes, produces gloss/shine

A

Polishing

25
Q

Waxes used in polishing

A

Beeswax
Carnauba Wax
Candelila Wax
Hard Paraffin Wax

26
Q

Addition of thin layer of polymer; increase in weight by 2-3%

A

Film coating

27
Q

Components of Film-Coated Tablet

A

Film Former
Alloying Substance
Plasticizer
Surfactant
Glossant
Volatile Solvent
Opaquants and colorant
Sweeteners, flavors, and Aromas

28
Q

Produces smooth, thin films

A

Film Former

29
Q

Provides water solubility or permeability

A

Alloying Substance

30
Q

Produce flexibility and elasticity

A

Plasticizer

31
Q

Enhance spreadability of film during application

A

Surfactant

32
Q

Provide sheen or gloss to the tablets

A

Glossant

33
Q

Allow spread of other components over the tablets while allowing evaporation to permit an effective & speedy operation

A

Volatile Solvent

34
Q

Make the tablets distinctive and aesthetically appearing

A

Opaquants and Colorants

35
Q

Enhance the acceptability of the tablet by the patient

A

Sweeteners, flavors, aromas

36
Q

Agents used in Film Coated Tablet Components

A

Film Former - Cellulose acetate pthalate
Alloying Substance - Polyethylene glycol
Plasticizer - Castor Oil, glycerin
Surfactant - Spans & Tweens, Polyoxythylene sorbitan derivatives
Glossant - Beeswax
Volatile Solvent - Alcohol, Acetone
Opaquants and colorant - TiO2, FD&C Dyes
Sweeteners, flavors, and Aromas - Saccharin, Vanillin

Manufacturing (13 decks)

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