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Manufacturing > Solid > Flashcards

Solid Flashcards

1
Q

Process in Tablet Manufacturing

A

Dispensing
Milling
Blending
Granulation
Tableting
Coating

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2
Q

Step in manufacturing process thru weighing and measuring

A

Dispensing

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3
Q

Objective of Dispensing

A

Accuracy of weight -> uniform dose

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4
Q

Methods of Dispensing

A

Hand scooping and weighing
Weighing with material lifting assistance
Automated dispensaries

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5
Q

Issues with Dispensing

A

Weighing accuracy
Dust control (dust collecting assistance)
Lot control of each ingredient
Material movement

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6
Q

Particle size reduction, sizing, crushing, grinding, pulverization

A

Milling

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7
Q

Mill for Cutting

A

Cutter Mill

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8
Q

Mill for Compression

A

Edge Runner Mill
End Runner Mill

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9
Q

Mill for Impact

A

Hammer Mill
Vibration Mill

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10
Q

Attrition

A

Roller Mill

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11
Q

Impact and Attrition

A

Ball Mill
Fluid Energy Mill

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12
Q

Cuts particles using knives; for fibrous materials

A

Cutter Mill

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13
Q

Crushes materials by 2 rotating wheels

A

Edge Runner Mill

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14
Q

Uses a high speed rotor to which swinging hammers are fixed

A

Hammer Mill

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15
Q

Uses air with very high pressure

A

Fluid Energy Mill

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16
Q

Consists of rotating cylindrical rolls

A

Roller Mill

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17
Q

Consists of a rotating cylindrical roll filled with balls

A

Ball Mill

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18
Q

Process of blending materials together into one mass

A

Mixing

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19
Q

All ingredients are loaded together, mixed and discharged as a single batch

A

Batch Type Mixer

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20
Q

Used for blending of free-flowing powders/granules

A

Tumbling Mixers/Blenders

21
Q

Used in mixing and granulation

A

High Speed Mixer-Granulators

22
Q

Used in drying of granules or coating of multiparticulates and blending powders before granulation

A

Fluidized Bed Mixers

23
Q

Convection; Motion of blade or paddle through the product

A

Agitator Mixer

24
Q

Tumbling Mixers/Blenders

A

Double Cone
Oblique Cone
Rotating cube
Y Cone
Twin Shell (V) Mixer

25
Q

Particle size enlargement to granules

A

Granulation

26
Q

Objectives of Granulation

A

Improve flowability and compressibility

27
Q

2 Methods of Granulation

A

Wet Granulation Method
Dry Granulation
Fluid Bed Granulation

28
Q

Most common method; addition of liquid binders to powders

A

Wet Granulation Method

29
Q

Advantages & Disadvantages of Wet Granulation

A

Advantages: Increased Compressibility
Improved Dissolution

Disadvantage: Not applicable to water/ moisture & heat sensitive (ex: Aspirin)

30
Q

Steps in Wet Granulation Method

A
  1. Blending of Ingredients
  2. Addition of Liquid Binder/Lubricating Fluid
  3. Screening the damp mass (Mesh #6-8)
  4. Drying the granulation (0.5 - 1%)
  5. Screening the dry granules (Mesh #12-20)
  6. Blending with lubricant and disintegrant
31
Q

Moisture Content of Wet Granulation

A

31-35%
Underwet – too soft
Overwet – too hard

32
Q

Rapid granulation and drying of batch, spraying of granulating solution onto the suspended particles, the dried rapidly in suspending air

A

Fluid Bed Granulation

33
Q

Powder mixture is compacted into large pieces and subsequently broken down into granules; for moisture and heat-sensitive materials

A

Dry Granulation / Precompression / Double Compression

34
Q

Example of substances produced in Dry granulation

A

Magnesium hydroxide
Aspirin
Ascorbic Acid
Acetaminophen
Thiamine

35
Q

Processes in Dry Granulation

A

Slugging/Slugging
Roller Compaction/Ribbon Blending

36
Q

A large tablet (slugs) is produced which is broken via milling to produce granular materials

A

Slugging/Rotary Compaction

37
Q

Instrument used in Slugging

A

Rotary Press
Hammer Mill
Oscillating granulator

38
Q

The powder is squeezed between two rollers to produce a sheet of material

A

Roller Compaction/Ribbon Blending

39
Q

Instrument used in Roller Compaction

A

Roller Compactor Chilsonator

40
Q

Compression of tablet components within a die cavity by pressure exerted by movement of 2 punches

A

Tableting

41
Q

Tableting Machine

A

Single Punch Press (Eccentric Press) - 200 tab/min
Multistation Press (Rotary Press) - >10,000tab/min

42
Q

Parts of Tableting Machine

A

Hopper
Feed Shoe/Feed Frame
Die
Punches (Upper, Lower)
Cam Tracks

43
Q

Part of tableting machine that transfer materials from hopper to die

A

Feed Shoe or Feed Frame

44
Q

Part of tableting machine that defines the size and shape

A

Die

45
Q

Part of tableting machine that compress the materials within the die

A

Punches

Upper Punch: Compression
Lower Punch: Ejection

46
Q

Part of tableting machine that guides the movement of punches

A

Cam Tracks

47
Q

Flowability problems

A

Arching/Bridging – arch-shaped obstruction forms above hopper outlet

Rat-Holing – discharge takes place only above hopper outlets

48
Q

Forms a stable, compact mass when pressure is applied

A

Compressibility

Manufacturing (13 decks)

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