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Manufacturing > Solid Dosage Forms > Flashcards

Solid Dosage Forms Flashcards

1
Q

Inert substance added to increase tablet size which is practical for compression

A

Diluent / Bulking Agent / Filler

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2
Q

Examples of Diluent

A

Lactose
Microcrystalline Cellulose
Mannitol
Xylitol

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3
Q

Most common diluent

A

Lactose

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4
Q

Lactose is incompatible with:

A

Incompatible with Primary & Secondary Amine
Alkali and Strong Oxidizers

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5
Q

Lactose used in Direct compression

A

Spray-dried Lactose and Anhydrous lactose

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6
Q

Lactose used in Wet Granulation

A

Hydrous Lactose

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7
Q

Most commonly used filler-binder in Direct Compression

A

Microcrystalline Cellulose

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8
Q

Diluent used in chewable tablet and has cooling effect

A

Mannitol (70% as sweet as sucrose)

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9
Q

Used in Sugar free chewable tablet and suitable for diabetic patient

A

Xylitol

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10
Q

Imparts cohesiveness and adhesion to powders causing them to form granules

A

Binders / Granulators

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11
Q

Examples of Binders

A

Starch
Starch paste
Pregelatinized Starch
Polyvinylpyrrolidone (PVP)
Ethylcellulose
Acacia
Tragacanth
Gelatin

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12
Q

Binder soluble in hot water

A

Starch paste

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13
Q

Binder soluble in cold water

A

Pregelatinized Starch

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14
Q

Binder for chewable Tablet

A

Polyvinylpyrrolidone (PVP)

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15
Q

Binder for moisture-sensitive materials

A

Ethylcellulose

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16
Q

Facilitates breakup of a tablet into smaller particles when in contact with water in the GIT

A

Disintegrants

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17
Q

Internal Addition of Disintegrant

A

Disintegrant is added before granulation

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18
Q

External Addition of Disintegrant

A

Disintegrant is added after granulation

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19
Q

Combination Method of Disintegrant

A

Both Internal and External addition, Most efficient

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20
Q

Mechanism of action of Disintegrants

A

Swelling
Wicking/Capillary Action
Effervescence or Release of Gas

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21
Q

Examples of Disintegrants

A

Starch

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22
Q

The oldest and most commonly used tablet disintegrant

A

Starch (10-15%)

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23
Q

Used for faster disintegration

A

Superdisintegrant (2-4%)

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24
Q

Examples of Superdisintegrants

A

Croscarmellose
Crospovidone
Sodium Starch glycolate

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25
Q

Improve the flowability of powders by reducing adhesion and cohesion

A

Flow activators

25
Q

Talc

A

Glidant 5%
Lubricant 1-5%

26
Q

Types of Flow Activators

A

Lubricant
Antiadherent
Glidant

27
Q

Reduce friction between the tablet surface and die wall to eject tablet easily

A

Lubricant

28
Q

Examples of Lubricants

A

Calcium stearate
Magnesium stearate
Mineral oil
Stearic acid
Zinc stearate

29
Q

Reduce sticking of tablet to the punche face and die wall

A

Antiadherent

30
Q

Examples of Anti-adherent

A

Purified talc; Mg stearate

31
Q

Improve flow characteristics

A

Glidant

32
Q

Examples of Glidants

A

Colloidal Silicon dioxide (Cab-O-Sil)

33
Q

Used to disguising of off-color drugs, product identification, and aesthetic purposes

A

Colorants

34
Q

Water-soluble colorants used as solutions

A

Dyes

35
Q

Water-insoluble/Oil-dispersable dyes that have been absorbed on hydrous oxide usually alumina, used as dry powders

A

Lakes

36
Q

FD&C Blue No. 1

A

Brilliant Blue

37
Q

Blue No. 2

A

Indigotine

38
Q

Green No. 3

A

Fast Green

39
Q

Red No. 3

A

Erythrosine

40
Q

Red No. 40

A

Allura Red

41
Q

Yellow No.5

A

Tartrazine

42
Q

Yellow No. 6

A

Sunset Yellow

43
Q

Improve palatability of formulation

A

Flavorants

44
Q

Masking Flavors (Salty)

A

Orange
Maple
Glycyrrhiza

45
Q

Masking Flavors (Sweet)

A

Grapes
Vanilla
Honey

46
Q

Masking Flavors (Sour)

A

Citrus
Raspberry
Anise

47
Q

Masking Flavors (Bitter)

A

Chocolate
Coffee

48
Q

Pineapple - Masking Flavorant

A

Butyl acetate

49
Q

Green Apple - Masking Flavorant

A

Ethyl valerate

50
Q

Banana - Masking Flavorant

A

Isoamyl acetate

51
Q

Acesulfame potassium

A

200x

52
Q

Acesulfame potassium uses

A

Candies
Chewing gums
Instant coffee
Tea

53
Q

Aspartame

A

180 -200x

54
Q

Aspartame is contraindicated to

A

Patient with Phenylketonuria
Aspartic Acid + Methanol + Phenylalanine

55
Q

Sucralose

A

600x

56
Q

High Intensity sweetener, Non-caloric Sweetener

A

Sucralose

57
Q

Saccharin

A

300x

58
Q

Bitter after taste, used in toothpaste

A

Saccharin

59
Q

Stevia

A

30x

60
Q

Herbal Sweetener

A

Stevia

61
Q

Sodium cyclamate/Magic Sugar

A

30x

Manufacturing (13 decks)

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