Solid Dosage Forms

Question 1

Inert substance added to increase tablet size which is practical for compression

Answer 1

Diluent / Bulking Agent / Filler

Question 2

Examples of Diluent

Answer 2

Lactose
Microcrystalline Cellulose
Mannitol
Xylitol

Question 3

Most common diluent

Answer 3

Lactose

Question 4

Lactose is incompatible with:

Answer 4

Incompatible with Primary & Secondary Amine
Alkali and Strong Oxidizers

Question 5

Lactose used in Direct compression

Answer 5

Spray-dried Lactose and Anhydrous lactose

Question 6

Lactose used in Wet Granulation

Answer 6

Hydrous Lactose

Question 7

Most commonly used filler-binder in Direct Compression

Answer 7

Microcrystalline Cellulose

Question 8

Diluent used in chewable tablet and has cooling effect

Answer 8

Mannitol (70% as sweet as sucrose)

Question 9

Used in Sugar free chewable tablet and suitable for diabetic patient

Answer 9

Xylitol

Question 10

Imparts cohesiveness and adhesion to powders causing them to form granules

Answer 10

Binders / Granulators

Question 11

Examples of Binders

Answer 11

Starch
Starch paste
Pregelatinized Starch
Polyvinylpyrrolidone (PVP)
Ethylcellulose
Acacia
Tragacanth
Gelatin

Question 12

Binder soluble in hot water

Answer 12

Starch paste

Question 13

Binder soluble in cold water

Answer 13

Pregelatinized Starch

Question 14

Binder for chewable Tablet

Answer 14

Polyvinylpyrrolidone (PVP)

Question 15

Binder for moisture-sensitive materials

Answer 15

Ethylcellulose

Question 16

Facilitates breakup of a tablet into smaller particles when in contact with water in the GIT

Answer 16

Disintegrants

Question 17

Internal Addition of Disintegrant

Answer 17

Disintegrant is added before granulation

Question 18

External Addition of Disintegrant

Answer 18

Disintegrant is added after granulation

Question 19

Combination Method of Disintegrant

Answer 19

Both Internal and External addition, Most efficient

Question 20

Mechanism of action of Disintegrants

Answer 20

Swelling
Wicking/Capillary Action
Effervescence or Release of Gas

Question 21

Examples of Disintegrants

Answer 21

Starch

Question 22

The oldest and most commonly used tablet disintegrant

Answer 22

Starch (10-15%)

Question 23

Used for faster disintegration

Answer 23

Superdisintegrant (2-4%)

Question 24

Examples of Superdisintegrants

Answer 24

Croscarmellose
Crospovidone
Sodium Starch glycolate

Question 25

Improve the flowability of powders by reducing adhesion and cohesion

Answer 25

Flow activators

Question 25

Talc

Answer 25

Glidant 5% Lubricant 1-5%

Question 26

Types of Flow Activators

Answer 26

Lubricant Antiadherent Glidant

Question 27

Reduce friction between the tablet surface and die wall to eject tablet easily

Answer 27

Lubricant

Question 28

Examples of Lubricants

Answer 28

Calcium stearate Magnesium stearate Mineral oil Stearic acid Zinc stearate

Question 29

Reduce sticking of tablet to the punche face and die wall

Answer 29

Antiadherent

Question 30

Examples of Anti-adherent

Answer 30

Purified talc; Mg stearate

Question 31

Improve flow characteristics

Answer 31

Glidant

Question 32

Examples of Glidants

Answer 32

Colloidal Silicon dioxide (Cab-O-Sil)

Question 33

Used to disguising of off-color drugs, product identification, and aesthetic purposes

Answer 33

Colorants

Question 34

Water-soluble colorants used as solutions

Answer 34

Dyes

Question 35

Water-insoluble/Oil-dispersable dyes that have been absorbed on hydrous oxide usually alumina, used as dry powders

Answer 35

Lakes

Question 36

FD&C Blue No. 1

Answer 36

Brilliant Blue

Question 37

Blue No. 2

Answer 37

Indigotine

Question 38

Green No. 3

Answer 38

Fast Green

Question 39

Red No. 3

Answer 39

Erythrosine

Question 40

Red No. 40

Answer 40

Allura Red

Question 41

Yellow No.5

Answer 41

Tartrazine

Question 42

Yellow No. 6

Answer 42

Sunset Yellow

Question 43

Improve palatability of formulation

Answer 43

Flavorants

Question 44

Masking Flavors (Salty)

Answer 44

Orange Maple Glycyrrhiza

Question 45

Masking Flavors (Sweet)

Answer 45

Grapes Vanilla Honey

Question 46

Masking Flavors (Sour)

Answer 46

Citrus Raspberry Anise

Question 47

Masking Flavors (Bitter)

Answer 47

Chocolate Coffee

Question 48

Pineapple - Masking Flavorant

Answer 48

Butyl acetate

Question 49

Green Apple - Masking Flavorant

Answer 49

Ethyl valerate

Question 50

Banana - Masking Flavorant

Answer 50

Isoamyl acetate

Question 51

Acesulfame potassium

Answer 51

200x

Question 52

Acesulfame potassium uses

Answer 52

Candies Chewing gums Instant coffee Tea

Question 53

Aspartame

Answer 53

180 -200x

Question 54

Aspartame is contraindicated to

Answer 54

Patient with Phenylketonuria Aspartic Acid + Methanol + Phenylalanine

Question 55

Sucralose

Answer 55

600x

Question 56

High Intensity sweetener, Non-caloric Sweetener

Answer 56

Sucralose

Question 57

Saccharin

Answer 57

300x

Question 58

Bitter after taste, used in toothpaste

Answer 58

Saccharin

Question 59

Stevia

Answer 59

30x

Question 60

Herbal Sweetener

Answer 60

Stevia

Question 61

Sodium cyclamate/Magic Sugar

Answer 61

30x