Solid Dosage Forms Flashcards
pH sensitive polymers
insoluble in aqueous media at low pH but with increasing pH, they experience an abrupt increase in solubility
what are nonpereils
sucrose spheres coated with drug and polymer
they are a form of multiparticulate
uses of sodium bicarbonate
can be used with an acid to cause effervescence
can increase the rate of gastric emptying which enables a faster speed of absorption
examples of diluents
lactose
microcrystalline cellulose
examples of lubricants
magnesium stearate
anti-caking agent
colloidal silicon dioxide
examples of diluents
lactose
dicalcium phosphate
starches
how is microcrystalline cellulose produced
partial hydration of cellulose
has good compressability and high tablet strength
absorbs moisture
what is wet granulation
includes grinding down drug and blending with a binder, put in a granulator, passed wet through a screen, dried in fluidised bed dryer, blended with excipients, compaction
process driven by surface tension and adhesion/cohesion between particles
liquid bridges develop between particles which can lead to solid bridging - increasing strength
what is slugging
dry granulation used for powder blends that cannot be directly pressed due to poor compressibility/flow
can be used for heat or moisture sensitive materials
what is dry roller compaction
dry powder passed between two rollers that compact materials at higher pressures
produces sheets of material in ribbons which are milled to granules
more economical and required less equipment
slow release rate of suppositories
due to high solubility in vehicle which results in low leaving tendency
