Drug Transporters

Question 1

what is transporter redundancy

Answer 1

when transports have an overlapping number of substrates

Question 2

what processes are involved in renal clearance

Answer 2

tubular active secretion

active reabsorption

Question 3

effect of GI efflux transporters

Answer 3

reduced F

Question 4

effect of GI uptake transporters

Answer 4

enable oral administration with actives or poor passive permeability

Question 5

tubular reabsorption

Answer 5

can be passive

mediated by transporters

Question 6

what is biliary excretion

Answer 6

transporters into bile tract may rate-control hepatic clearance

Question 7

what is hepatic metabolism

Answer 7

transporters into hepatocytes may rate-control hepatic clearance

Question 8

statins

Answer 8

liver is the sit of action and the sit of clearance
OATP1 facilitates hepatic uptake and low activity may decrease cholesterol lowering effect, increase plasma concentration and increase risk of muscle toxicity

Question 9

factors that affect transporter expression

Answer 9

drugs, environmental chemicals, endogenous ligands (bile salts)

Question 10

what are pharmacogenetics

Answer 10

genetic polymorphisms of transporter genes that may affect PK