PPIs Flashcards
1
Q
PPI target site
A
cross membrane of parietal cells into acidic canaliculae
PPIs then ionised and cannot cross out of cell
2
Q
pH activation
A
canalicular are only place in the body with pH low enough to activate PPIs
3
Q
liver toxicity
A
can be caused by thioamide group in molecule
4
Q
esomeprazole vs omeprazole
A
esomeprazole has better performance and is less hydroxylated by CYP and has a reduced clearance rate, but there is no difference in action mechanism
