Soft Tissue Tumors (Dumbledorf) Flashcards by Jennifer Watson

fatty tumors

lipoma/liposarcoma

How well did you know this?

Not at all

Perfectly

fibrous tumors

reactive proliferans/fibromatosies/fibrosarcoma

How well did you know this?

Not at all

Perfectly

fibrohistiocytic tumors

benign and malignant histiocytoma

dematofibroscarcoma protuberans

How well did you know this?

Not at all

Perfectly

smooth muscle tumors

leiomyoma/leiomyosarcoma

How well did you know this?

Not at all

Perfectly

as mesenchymal proliferations that occur in the extraskeletal, nonepithelialized tissues of the body, excluding the viscera, coverings of the brain, and the lymphoreticular system

definition of soft tissue tumors

How well did you know this?

Not at all

Perfectly

a connective tissue neoplasm, usually highly malignant, formed by proliferation of mesodermal cells

sarcoma

How well did you know this?

Not at all

Perfectly

rapidly growing, small, benign, fibrous proliferation on the subcutis, usually encountered as a small mass

nodular fascitis

How well did you know this?

Not at all

Perfectly

epidemiology of nodular fascitis

young adult

*sometime after trauma

How well did you know this?

Not at all

Perfectly

Where on the body is nodular fasciitis most commonly seen?

arms

**particularly the flexor aspects of the forarms**

How well did you know this?

Not at all

Perfectly

What is the key feature that distinguishes myositis ossificans from a malignancy?

MATURE, woven bone is well formed at peripher BUT there is IMMATURUE bone at the center

**malignancies lack a maturation pattern **

How well did you know this?

Not at all

Perfectly

What are these? What is the major difference?

top : liposarcoma (malignant)

bottom: lipoma (benign)

How well did you know this?

Not at all

Perfectly

Nodular Fasciitis

(rapidly growing, small, benign, fibrous proliferation on the subcutis)

How well did you know this?

Not at all

Perfectly

How well did you know this?

Not at all

Perfectly

fixed flexion contracture of the hand where the fingers bend towards the palm and cannot be fully extended, ring finger and pinky finger are most commonly affected

Dupuytren contracture

(type fo superficial fibromatosis)

How well did you know this?

Not at all

Perfectly

Where do superficial fibromatoses commonly arise?

hand, feet, penis

How well did you know this?

Not at all

Perfectly

Peyronie disease

penile fibromatoses

How well did you know this?

Not at all

Perfectly

Ledderhose disease

plantar fibromatoses
**younger pts and often bilateral

How well did you know this?

Not at all

Perfectly

Dupuytren contractures

palmar fibromatoses
**usually presents bilaterally

How well did you know this?

Not at all

Perfectly

arise in the digits of infants and young children and are characterized by peculiar inclusion-like condensations of cytoplasmic actin.

infantile digital fibromatoses

How well did you know this?

Not at all

Perfectly

myositis ossificans

Mature, woven bone at periphery (right) and Immature bone at center (left)

How well did you know this?

Not at all

Perfectly

lipoblast

in liposarcoma

How well did you know this?

Not at all

Perfectly

“tissue culture” appearence

nodular fascitis (histo)

How well did you know this?

Not at all

Perfectly

woven bone in granulation tissue

reactive proliferans: myositis ossificans

How well did you know this?

Not at all

Perfectly

What is going on in the plam of a hand with a Dupuytren contracture (i.e. what is making the hand look funny?)

the tissues under the skin on the palm of the hand thicken and shorten so that the tendons connected to the fingers cannot move freely
The palmar aponeurosis becomes hyperplastic and undergoes contracture

How well did you know this?

Not at all

Perfectly

epidemiology of Dupuytren contracture

Incidence increases after the age of 40; at this age men are affected more often than women. After the age of 80 the distribution is about even.

deep fibromatosis

Where a deep fibromatoses typically found in and what is the sex predominance... 1. pediatic pts 2. pts in late 20s 3. adult years

1. extra abdominal and female 2. abdominal wall and female 3. extra abdominal and no sex predominance

a tumor of mesenchymal cell origin that is composed of malignant fibroblasts in a collagen background

fibrosarcoma

fibrosarcomas of bone are (painless or painful)

painful

fibrosarcomas are a (soft tissue mass or bone tumor)

BOTH

Where do fibrosarcomas of bone typically form?

lowe extremities, esp femur and tibia (also, metaphysis of long bones and in the pelvis)

epidemiology of fibrosarcoma of bone

Men \> women can occur @ any age but most commonly in 30s

Where do fibrosarcoma of soft tissue usually arise?

thigh and posterior knee

Fibrosarcomas of soft tissue are (painless or painful)

painless

fibrosarcoma of soft tissue is generally found (superfical or deep) to the fascia

deep

non-cancerous growth of dermal dendritic histiocytic cells

dermatofibroma (aka fibrous histiocytoma)

Where do dermatofibromas most commonly arise?

arms and legs

Why will a dimple form in the skin over a dermatofibroma when it is squeezed?

the skin is attatched to the underying fibrous tissue

What layers of the skin does a dermatofibrosarcoma protuberans affect?

arises in dermis and invades deeper subcutaneous tissue (fat, fascia, muscle, bone)

cellular origin of dermatofibrosarcoma protuberans

fibroblastic, histocytic, or neuralectodermal OR pluripotential progenitor cells, such as undifferentiated mesenchymal cells

fibroblastlike and histiocytelike cells in varying proportions, with spindled and rounded cells exhibiting a storiform arrangement.

malignant fibrous histocytoma

What is the most significant prognostic factor for a malignant fibrous histiocytoma?

stage (defined by grade, size, and +/- mets)

Where do malignat fibrous histiocytoma commonly metastazise to?

lungs (90%), bone (8%), liver (1%)

"fish flesh” appearance.

rhabdomyosarcoma

“storiform” (woven mat) pattern

malignat fibrous histocytoma

Reactive bone formation in muscle as a result of injury, usually blunt trauma

reactive proliferants: myositis ossificans

What cells make up a rhabdomyosarcoma?

rhabdomyoblasts

What are the most common site for a rhabdomyosarcoma to arise?

1. adjacent to the base of the skull (parameningeal) 2. around the eye 3. nose and throat 4. arms and lefs 5. GU sooooo, pretty much anywhere

most common place to find leiomyoma

uterus | (smooth muscle tumor)

Uterine leiomyoma are.. symptomatic, asymptomatic regress or progress after menopause estrogen sensitive or insensitive

asymptomatic regress estrogen senstivie (why they prob regress after menopause)

leimyoma affect \_\_\_\_% of reproductve age women

25-40% that shit be cray

Leiomyosarcoma can arise anywhere in the body, but is more common in the ...

uterus, abdomen, or pelvis

sarcomas spread via (blood stream or lymphaics)

blood stream

Where do leiomyosarcomas typically metastasize to?

lungs

elongated “strap” cells

Rhabdomyosarcoma

bland histiocytic type cells interdigitate between normal collagen bundles

Dermatofibroma (fibrous histiocytoma) \*\*not as structured/organized a malignant fibrous tumor

cigar shaped nuclei

Leiomyoma or leiomyosarcoma

arises at the site of a minor injury, especially an insect bite or thorn prick

Dermatofibroma (fibrous histiocytoma)

locally aggressive fibrous tumor with a high recurrence rate;

Dermatofibrosarcoma protuberans

Can get large enough that they outgrow their blood supply and may undergo areas of necrosis with ultimate formation of one or more cysts

Leiomyoma or leiomyosarcoma

dermatofibroma

leiomyosarcoma with partially hemorrhagic necrosis

fibrosarcoma "herringbone" pattern

dermatofibrosarcoma protruberans shows greater cellularity than dermatofibroma with greater cellular atypia, though without mitotic figures or necrosis.