SNRIs

Question 0

Venlafaxine

Answer 0

SNRI, primary metabolite (desvenlafxine) is active, Tx for hot flashes. Also used in depression and sometimes neuropathic pain.

Question 1

SNRIs

Answer 1

Inhibit both NE and 5-HT reuptake. SE: Increased BP, SIADH, hyponatremia.

Question 2

Desvenlafaxine

Answer 2

It is a separate medication as well as the metabolite of venlafaxine. Does all the same shit.

Question 3

Duloxetine

Answer 3

SNRI, greater efficacy in depression then SSRI, Moderate inhibition of CYP2D6, SE; anorexia, drowsiness, HA, insomnia, N/V, Dry mouth. Hepatotoxic!!!!-dont give in liver disease. Contraindicated in 3rd trimester. Tx for depression, better than SSRI for physical symptoms.

Question 4

Milnacipran

Answer 4

SNRI. Tx for fibromyalgia as well as depression. SE: GI upset, increased BP, SIADH.

Question 5

Levomilnacipran

Answer 5

SNRI, Tx for major depressive disorder. SE: GI upset, increased BP, SIADH.