Barbituates

Question 0

Pentobarbital (Neumbutal Sodium)

Answer 0

Barbituate. Contraindicated: any porphyria and pulmonary insufficiency

Question 1

Barbituates (whole class)

Answer 1

Act by binding to modulatory site on GABAa to prolong actions of GABA (increase Cl- influx).
Marked CNS depression such that they produce hypnosis and can produce anesthesia. Drugs of euphoria- drugs of abuse
Low margin of safety. At high doses: decrease resp. drive
Supra-additive CNS depressive effects by combining 2 drugs esp. w/alcohol. Impairs REM.
Lipid soluble, enter CNS easily (degree of lipid solubility determines onset and duration of action)
Metabolized by liver, and induces hepatic enzymes with chronic use
Tx toxicity: supportive, dont use stimulants, cleared w/alkalinization of urine.
Withdrawal is life threatening.
Absolute contraindication is any porphyria, also pulmonary insufficiency.

Question 2

Phenobarbital (Luminal Sodium)

Answer 2

Long acting anticonvulsant

Question 3

Secobarbital (Seconal)

Answer 3

Barbituate

Question 4

Thiopental

Answer 4

Barbituate, ultra short acting, used for induction of anesthesia.

Question 5

Barbituate Drug Names

Answer 5

Pentobarital
Phenobarbital
Secobarbital
Thiopental