Sm Intestine and Colon Pt 3

Question 1

Inflammatory polyps in UC and CD

Answer 1

inflammatory pseudopolyps

just what is left after erosion

Question 2

Hamartomatous polyp

Answer 2

rectal bleeding in children
non-neoplastic
left-sided

Question 3

Hyperplastic polyps

Answer 3

most common polyp in adults, does not become adenocarcinoma

Question 4

Adenomas become

Answer 4

carcinomas

Question 5

Peutz-Jegher polyps

Answer 5

result of STK11 tumor suppressor gene loss of function

Peutz-Jegher syndrome

Question 6

Adenoma vs dysplasia

Answer 6

adenoma: mass lesion
dysplasia: flat lesion

Question 7

Sessile serrated polyps

Answer 7

dysplasia –> adenocarcinoma

resemble hyperplastic, but this one is dysplastic

Question 8

FAP defect

Answer 8

APC tumor suppressor gene

inherit one, 2nd mutation is sporadic

Question 9

FAP inheritance pattern

Answer 9

autosomal dominant

Question 10

KRAS mutation screening of tumors purpose

Answer 10

if not mutated, then EGFR antibody can downregulate proliferation pathway

Question 11

Risk of adenocarcinoma in FAP

Answer 11

100%

Question 12

HNPCC/Lynch syndrome defect

Answer 12

mismatch repair defect

inherit 1 hit, other is acquired

Question 13

ASA and NSAIDs

colorectal cancer

Answer 13

have protective effect against adenocarcinoma

Question 14

Most common site of metastasis

adenocarcinoma of colon

Answer 14

liver

Question 15

Apple-core sign on barium enema

Answer 15

left-sided colon cancer

Question 16

Most small intestine adenocarcinoma is found in this area

Answer 16

ampulla of Vater

Question 17

Most neuroendocrine tumors are found where?

Answer 17

ileum, jejunum

Question 18

Carcinoid tumors aften found

singular/in multiple

Answer 18

in multiple 30% of time

Question 19

Melanosis coli

Answer 19

dark color of colon from some laxatives

looks like necrotic bowel from infarction

Question 20

Pseudomyxoma peritonei

pathology

Answer 20

appendiceal mucinous tumors

presence of abundant mucinous material on peritoneal surfac

Question 21

Anal fissure

Answer 21

linear separation of tissues in anal canal

Question 22

Anal carcinoma

from what type of cells

Answer 22

epithelial cells

Question 23

Anal carcinoma

association

Answer 23

HPV 16 and 18