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633 > Slide Set 2 Moska- Inflammation > Flashcards

Slide Set 2 Moska- Inflammation Flashcards

1
Q

Acetaminophen a NSAID?

What is it generally considered?

But it Inhibits the synthesis of?

It has effects similar to?

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2
Q

How are allergic rxns classified?

Immediate hypersensitivity caused and triggered by?

Antibody mediated?

Immune complex mediated?

T lymphocyte mediated?

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3
Q

Review of Allergic Rxns

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4
Q

Immediate Hypersensitivity?

Allergies?

Mechanism 3 of them

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5
Q

IgE Overview

Is IgE common? Why is this?

IgE instegates immediate? How does it cause this?

Mast cell mediators:

Performed mediators are released de novo synthesis of lipid mediators produces symptoms withiin minutes what happens after?

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6
Q

Mast Cell Mediators

Histamine, Serotonin, Vasoactive amines and Lipid mediators what do they cause?

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7
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8
Q

Histamine:

Principle mediator in?

What are the 4 receptors?

Metabolism of Histamine? Where is the enzyme that synthesizes it expressed? What can store histamine?

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9
Q
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10
Q

Roles of Histamine

Mediator of?

Released in the gut by? Increases?

Stored where? And acts as a? Occur in both?

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11
Q

Expressed in many tissues, such as the CNS, vascular smooth muscle and GI tract

General Function of H1R?

Functions in Immune modulation?

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12
Q

Physiological Relevance of H1R 5 things its involved in.

Clincal Relevance?

Antagonists? 4

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13
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14
Q

H2R

General Functions? 4

Function in Immune Modulation? 5

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15
Q

H2R

Physiological Relevance?

Clinical Relevance?

Antagonists?

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16
Q

Structure

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17
Q

H3R
Functions, Immune modulations, physiologic relevance

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18
Q

H3R

Clinical Relevance and Antagonists?

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19
Q

H4R

Expressed where?

General functions?

Functions in Immune modulation?

Clinical Relevance?

Antagonists?

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20
Q

H Receptor effects

Tissue, Effect, Clinical Effect, Receptors

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21
Q

Histamine Receptor Summary

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22
Q

Histamine and Asthma

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23
Q

Histamine and Itch?

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24
Q

Immedicate Hypersensitivity and Anaphylaxis

Immediate Hypersensitivity Background

Clinical Manifestations?

Definition of Anaphylaxis

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25
Q

Organ systems in Anaphylaxis?

What drives a sudden drop in blood pressure?

How does death from anaphylaxis usually occur?

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26
Q

Anaphylaxis Treatment Goals?

What do you use?

What is the mechanism of this drug? Acts on 3 things

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27
Q

Questions to Consider for anaphylaxis

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28
Q

questions

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29
Q

Pharmacology of Immunosuppression

Immunosuppressive drugs can be grouped into 3 categories?

What are the goals for transplant immunosuppression?

A
30
Q

Rejection of Transplant Tissues

Hyperacute

Acute

Chronic

Compliment cascade is activated

Inflammation and tissue damage ensues

Inflammation, smooth muscle proliferation, and vessel occlusion ensues

T lymphocytes react with graft antigens and produce cytokines

Performed antibodies react with transplant antigens

T lymphocytes react with transplant antigens

A
31
Q

Induction Therapy

Goal:

Induction strategies?

What based therapy?

Drug used? Mechanism, Indication, AEs?

A
32
Q
A
33
Q

Induction: Antibody Based Therapies

Drug?

Mechanism:

Indication:

AEs

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34
Q
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35
Q

Induction/Rejection Therapy

Horse anti-thymocyte globulin (ATGAM)

Mechanism

Indication

AEs?

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36
Q

Maintenance Therapy

Goals: 3 goals

Maintenance regimens?

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37
Q

Maintenance Therapy

5 major agents available

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38
Q

Azothioprine

Mechanism

Treatment indications?

AEs?

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39
Q

Mycophenolate

Mechanism?

Tx indications?

AEs?

A
40
Q

Leflunomide

Mechanism

Indication

AEs?

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41
Q

Cyclosporine and Tacrolimus what type of drugs?

Mechanism

Tx indication?

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42
Q

Calcineurin Inhibitors

AEs

Vascular

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43
Q

mTOR Inhibitors 2

Mechanism

Tx indication

AEs

A
44
Q

Anti CD20 3 meds

Mechanism

Tx indication

AEs

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45
Q

Belatacept

MOA

Tx indication

AEs

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46
Q
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47
Q

Antirejection Therapy

What are included in the Tx options?

Monoclonal Antibodies?

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48
Q

AntiCD20

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49
Q

Eculizumab (Soliris)

Mechanism

Tx Indication

AEs

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50
Q

Pharmacology of Autoimmune diseases

In what diseases would immunosuppression be useful? 3

Immunosuppressive drugs? 6 total but 3 classes

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51
Q

TNF-a inhibitors? 3

Mechanism

Tx indication

AEs

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52
Q

Methotrexate

MOA

Indication

AEs

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53
Q
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