Slide Set 2 Moska- Inflammation Flashcards

1
Q

Acetaminophen a NSAID?

What is it generally considered?

But it Inhibits the synthesis of?

It has effects similar to?

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2
Q

How are allergic rxns classified?

Immediate hypersensitivity caused and triggered by?

Antibody mediated?

Immune complex mediated?

T lymphocyte mediated?

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3
Q

Review of Allergic Rxns

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4
Q

Immediate Hypersensitivity?

Allergies?

Mechanism 3 of them

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5
Q

IgE Overview

Is IgE common? Why is this?

IgE instegates immediate? How does it cause this?

Mast cell mediators:

Performed mediators are released de novo synthesis of lipid mediators produces symptoms withiin minutes what happens after?

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6
Q

Mast Cell Mediators

Histamine, Serotonin, Vasoactive amines and Lipid mediators what do they cause?

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7
Q
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8
Q

Histamine:

Principle mediator in?

What are the 4 receptors?

Metabolism of Histamine? Where is the enzyme that synthesizes it expressed? What can store histamine?

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9
Q
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10
Q

Roles of Histamine

Mediator of?

Released in the gut by? Increases?

Stored where? And acts as a? Occur in both?

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11
Q

Expressed in many tissues, such as the CNS, vascular smooth muscle and GI tract

General Function of H1R?

Functions in Immune modulation?

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12
Q

Physiological Relevance of H1R 5 things its involved in.

Clincal Relevance?

Antagonists? 4

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13
Q
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14
Q

H2R

General Functions? 4

Function in Immune Modulation? 5

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15
Q

H2R

Physiological Relevance?

Clinical Relevance?

Antagonists?

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16
Q

Structure

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17
Q

H3R
Functions, Immune modulations, physiologic relevance

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18
Q

H3R

Clinical Relevance and Antagonists?

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19
Q

H4R

Expressed where?

General functions?

Functions in Immune modulation?

Clinical Relevance?

Antagonists?

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20
Q

H Receptor effects

Tissue, Effect, Clinical Effect, Receptors

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21
Q

Histamine Receptor Summary

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22
Q

Histamine and Asthma

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23
Q

Histamine and Itch?

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24
Q

Immedicate Hypersensitivity and Anaphylaxis

Immediate Hypersensitivity Background

Clinical Manifestations?

Definition of Anaphylaxis

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25
Organ systems in Anaphylaxis? What drives a sudden drop in blood pressure? How does death from anaphylaxis usually occur?
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Anaphylaxis Treatment Goals? What do you use? What is the mechanism of this drug? Acts on 3 things
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Questions to Consider for anaphylaxis
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questions
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Pharmacology of Immunosuppression Immunosuppressive drugs can be grouped into 3 categories? What are the goals for transplant immunosuppression?
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Rejection of Transplant Tissues Hyperacute Acute Chronic Compliment cascade is activated Inflammation and tissue damage ensues Inflammation, smooth muscle proliferation, and vessel occlusion ensues T lymphocytes react with graft antigens and produce cytokines Performed antibodies react with transplant antigens T lymphocytes react with transplant antigens
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Induction Therapy Goal: Induction strategies? What based therapy? Drug used? Mechanism, Indication, AEs?
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Induction: Antibody Based Therapies Drug? Mechanism: Indication: AEs
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Induction/Rejection Therapy Horse anti-thymocyte globulin (ATGAM) Mechanism Indication AEs?
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Maintenance Therapy Goals: 3 goals Maintenance regimens?
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Maintenance Therapy 5 major agents available
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Azothioprine Mechanism Treatment indications? AEs?
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Mycophenolate Mechanism? Tx indications? AEs?
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Leflunomide Mechanism Indication AEs?
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Cyclosporine and Tacrolimus what type of drugs? Mechanism Tx indication?
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Calcineurin Inhibitors AEs Vascular
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mTOR Inhibitors 2 Mechanism Tx indication AEs
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Anti CD20 3 meds Mechanism Tx indication AEs
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Belatacept MOA Tx indication AEs
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Antirejection Therapy What are included in the Tx options? Monoclonal Antibodies?
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AntiCD20
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Eculizumab (Soliris) Mechanism Tx Indication AEs
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Pharmacology of Autoimmune diseases In what diseases would immunosuppression be useful? 3 Immunosuppressive drugs? 6 total but 3 classes
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TNF-a inhibitors? 3 Mechanism Tx indication AEs
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Methotrexate MOA Indication AEs
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