Slide Set 2 Moska- Inflammation

Question 1

Acetaminophen a NSAID?

What is it generally considered?

But it Inhibits the synthesis of?

It has effects similar to?

Answer 1

Question 2

How are allergic rxns classified?

Immediate hypersensitivity caused and triggered by?

Antibody mediated?

Immune complex mediated?

T lymphocyte mediated?

Answer 2

Question 3

Review of Allergic Rxns

Answer 3

Question 4

Immediate Hypersensitivity?

Allergies?

Mechanism 3 of them

Answer 4

Question 5

IgE Overview

Is IgE common? Why is this?

IgE instegates immediate? How does it cause this?

Mast cell mediators:

Performed mediators are released de novo synthesis of lipid mediators produces symptoms withiin minutes what happens after?

Answer 5

Question 6

Mast Cell Mediators

Histamine, Serotonin, Vasoactive amines and Lipid mediators what do they cause?

Answer 6

Answer 7

Question 8

Histamine:

Principle mediator in?

What are the 4 receptors?

Metabolism of Histamine? Where is the enzyme that synthesizes it expressed? What can store histamine?

Answer 8

Answer 9

Question 10

Roles of Histamine

Mediator of?

Released in the gut by? Increases?

Stored where? And acts as a? Occur in both?

Answer 10

Question 11

Expressed in many tissues, such as the CNS, vascular smooth muscle and GI tract

General Function of H1R?

Functions in Immune modulation?

Answer 11

Question 12

Physiological Relevance of H1R 5 things its involved in.

Clincal Relevance?

Antagonists? 4

Answer 12

Answer 13

Question 14

H2R

General Functions? 4

Function in Immune Modulation? 5

Answer 14

Question 15

H2R

Physiological Relevance?

Clinical Relevance?

Antagonists?

Answer 15

Question 16

Structure

Answer 16

Question 17

H3R
Functions, Immune modulations, physiologic relevance

Answer 17

Question 18

H3R

Clinical Relevance and Antagonists?

Answer 18

Question 19

H4R

Expressed where?

General functions?

Functions in Immune modulation?

Clinical Relevance?

Antagonists?

Answer 19

Question 20

H Receptor effects

Tissue, Effect, Clinical Effect, Receptors

Answer 20

Question 21

Histamine Receptor Summary

Answer 21

Question 22

Histamine and Asthma

Answer 22

Question 23

Histamine and Itch?

Answer 23

Question 24

Immedicate Hypersensitivity and Anaphylaxis

Immediate Hypersensitivity Background

Clinical Manifestations?

Definition of Anaphylaxis

Answer 24

Question 25

Organ systems in Anaphylaxis?

What drives a sudden drop in blood pressure?

How does death from anaphylaxis usually occur?

Answer 25

Question 26

Anaphylaxis Treatment Goals?

What do you use?

What is the mechanism of this drug? Acts on 3 things

Answer 26

Question 27

Questions to Consider for anaphylaxis

Answer 27

Question 28

questions

Answer 28

Question 29

Pharmacology of Immunosuppression

Immunosuppressive drugs can be grouped into 3 categories?

What are the goals for transplant immunosuppression?

Answer 29

Question 30

Rejection of Transplant Tissues

Hyperacute

Acute

Chronic

Compliment cascade is activated

Inflammation and tissue damage ensues

Inflammation, smooth muscle proliferation, and vessel occlusion ensues

T lymphocytes react with graft antigens and produce cytokines

Performed antibodies react with transplant antigens

T lymphocytes react with transplant antigens

Answer 30

Question 31

Induction Therapy

Goal:

Induction strategies?

What based therapy?

Drug used? Mechanism, Indication, AEs?

Answer 31

Answer 32

Question 33

Induction: Antibody Based Therapies

Drug?

Mechanism:

Indication:

AEs

Answer 33

Answer 34

Question 35

Induction/Rejection Therapy

Horse anti-thymocyte globulin (ATGAM)

Mechanism

Indication

AEs?

Answer 35

Question 36

Maintenance Therapy

Goals: 3 goals

Maintenance regimens?

Answer 36

Question 37

Maintenance Therapy

5 major agents available

Answer 37

Question 38

Azothioprine

Mechanism

Treatment indications?

AEs?

Answer 38

Question 39

Mycophenolate

Mechanism?

Tx indications?

AEs?

Answer 39

Question 40

Leflunomide

Mechanism

Indication

AEs?

Answer 40

Question 41

Cyclosporine and Tacrolimus what type of drugs?

Mechanism

Tx indication?

Answer 41

Question 42

Calcineurin Inhibitors

AEs

Vascular

Answer 42

Question 43

mTOR Inhibitors 2

Mechanism

Tx indication

AEs

Answer 43

Question 44

Anti CD20 3 meds

Mechanism

Tx indication

AEs

Answer 44

Question 45

Belatacept

MOA

Tx indication

AEs

Answer 45

Answer 46

Question 47

Antirejection Therapy

What are included in the Tx options?

Monoclonal Antibodies?

Answer 47

Question 48

AntiCD20

Answer 48

Question 49

Eculizumab (Soliris)

Mechanism

Tx Indication

AEs

Answer 49

Question 50

Pharmacology of Autoimmune diseases

In what diseases would immunosuppression be useful? 3

Immunosuppressive drugs? 6 total but 3 classes

Answer 50

Question 51

TNF-a inhibitors? 3

Mechanism

Tx indication

AEs

Answer 51

Question 52

Methotrexate

MOA

Indication

AEs

Answer 52

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Answer 67