Moskavitz Quiz 2 Flashcards
What would be causing exercise induced asthma?
What is the same and different with exercise and non?
LTs and Asthma
Asthma is Characterized by?
Airway inflammation plays a key role in the pathogenesis of asthma this is characterized by what 3 things?
What LT appears to have an important role in asthma? Where are increased levels of this found?
Given this information what effects would you expect LTs to have on inflammatory cell?
LT inhibition Clinical Use
Asthma: What are the 2 drugs that can be used in children or adults?
What are the 5 clinical effects of LT inhibition?
Known inducers of lipoxins? 2 kinds
What are the 4 leukotriene receptors?
Which one mediates bronchoconstrictions, mucus secretion, and airway edema?
Which one is a lower affinity receptor for LTB4?
Which is a high affinity receptor for LTB4, that mediates most of its chemoattractant and proinflammatory action?
Appears to play a role in intestinal barrier function and inflammatory disease?
Contributes to inflammation, vascular permeability, tissue fibrosis?
There are currently no specific antagonists to this receptor?
Presence of AA cysteine?
LT inhibition Pharmacology
CysLT1 antagonists? What are their endings? Which one is preferred?
What medication is a 5-LO inhibitor what does it stop? Why is use limited? Toxicity of this drug is related to?
Isoprotanes
What are they? How are they formed?
Levels in blood are much higher than?
What are the 2 isprostanes? What do they do?
Isoprostane levels might be indicative of?
Dont play a role in?
Epoxygenase Pathway
What enzyme converts AA into 4 EET isomers?
What are the 4 functions of EET?
EETs get converted into certain acids what causes this and what is the product? This decreases what? What inhibition is being evaluated for therapy?
LIPOX PATHWAY
Second major fate of what molecule?
Leads to the formation of what two things?
Synthesis is mediated by what 2 Proteins?
What is the first product of the pathway? This product can be converted into what 4 LTs?
Leukocytes have the ability to?
What diseases are leukotrienes involved in?
Clinical Focus: LTs and Asthma
What are the most potent bronchoconstrictors in human?
Thousands of times more potent than?
What do allergens induce in pts?
Airways Remodeling:
LTs promote the proliferation of what two cell types?
LTs increase the deposition of? Which is an important feature of what disease?
LTs affect the human airway muscle tone, how does this work? 3 points
Lipoxins: Resolution of Inflammation
Lipoxins are? They play a vital role in?
What 3 receptor types do Lipoxins have their effects on?
What are the 6 roles of Lipoxins?
