sleep Flashcards

1
Q

neurons in what nucleus generate the circadian rhythm?

A

suprachiasmatic

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2
Q

The protein products from what act as TF’s to increase period and crypto chrome?

A

BMAL1 and CLOCK

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3
Q

The transcription factors BMAL1 and clock act on what?

A

PERIOD and Cryptochrome

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4
Q

eyes opened or closed in alpha waves?

A

Closed

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5
Q

Where do alpha waves come from?

A

Occipital cortex

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6
Q

What is the amplitude and frequency of alpha waves?

A

High frequency, low amplitude

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7
Q

eyes opened or closed in beta waves?

A

Open

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8
Q

Where do beta waves come from?

A

Frontal, parietal cortex

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9
Q

Amplitude and frequency of beta waves?

A

High frequency, low amplitude

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10
Q

Are gamma wave fast or slow?

A

Slow

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11
Q

What are gamma waves associated with?

A

motor response

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12
Q

Theta waves are?

A

Slow, higher amplitude

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13
Q

When do theta waves appear? (3)

A
  1. ) frustration
  2. ) disappointment
  3. ) sleep
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14
Q

Delta waves are the?

A

Slowest, largest

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15
Q

What do delta waves represent?

A

Dissociation of the cortex and thalamus

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16
Q

What does alpha block or alerting response mean?

A

Eyes opened and changed to a B wave

17
Q

What waves predominate in infants?

A

Beta waves

18
Q

Changes in waves come from what 4 things?

A
  1. ) hypoglycemia
  2. ) decreased body temp
  3. ) decreased adrenal function
  4. ) Increased PaCO2
19
Q

What is the EEG in REM?

A

Low amplitude, high frequency

20
Q

Sleep induction involves?

A

PGD2 accumulation in the periphery. This leads to adenosine accumulation in the CSF.

21
Q

Adenosine binds where?

A

Ventral Preoptic Region. VPO

22
Q

VPO neurons inhibit what?

A

ARAS

23
Q

REM sleep is induced by what neurotransmitter?

A

Ach

24
Q

Where is Ach released?

A

Geniculate body

25
Q

Large muscle paralysis requires the?

A

Locus Ceruleus. Inhibitory input into the a-motor neurons

26
Q

Waking up requires the release of? From where?

A

Orexins. Lateral hypothalamus

27
Q

Waking up also requires?

A

Histamine and NE

28
Q

What happens in stage N1 of sleep?

A

EEG slows down

29
Q

What happens in stage N2 of sleep?

A

Sleep spindles and K complexes

30
Q

What happens in stage N3 of sleep?

A

Delta waves

31
Q

Other names for when the eyes opened and waves are changed to beta?

A

alpha block or alerting response

32
Q

You are more likely to awaken from what sleep?

A

REM