Pulm Path Lecture 2 Flashcards
What is the radiology finding associated with idiopathic pulmonary fibrosis?
Basilar infiltrates with progression to honeycomb lung.
What are the clinical findings associated with IPF?
Dyspnea, crackles, restrictive pattern on PFT.
What are the 3 contributing factors to IPF?
- ) Environmental
- ) Genetic
- ) Age >50
Diagnosis of IPF requires?
classic findings on high resolution CT or biopsy
Pulmonary biopsy of IPF shows?
Findings of usual interstitial pneumonia (UIP)
What are potential therapies for IPF?
Transplantation & drugs that block fibrosis
What makes non-specific interstitial pneumonia different than IPF?
It has a uniform pattern of fibrosis and inflammation. It also has a better prognosis
What is COP?
Cryptogenic Organizing Pneumonia
What is the histological feature of COP?
Masson bodies (organizing plugs of connective tissue)
How do you diagnose COP?
It is a diagnosis of exclusion
How do you treat COP?
Oral steroids. There is a good prognosis
What is the definition of sarcoidosis?
Systemic disease manifesting as non-caseating granulomas
Desquamative interstitial pneumonia shows?
stuffed alveolar spaces full of macrophages
What is the treatment for DSIP?
Stop smoking and corticosteroids
When does DSIP present?
In smokers in the 4th-5th decade
What is RB-ILD?
respiratory bronchiolitis - interstitial lung disease
When does RB-ILD present?
earlier than DSIP, 3rd-4th decade of life
Describe the 3 stages of RB-ILD
- ) fewer macrophages than DSIP
- ) peri bronchiolar metaplasia with abnormally located cilia cells
- ) Fibrosis in advanced cases
Is RB-ILD reversible?
Yes, if caught early with smoking cessation
LCH stands for what?
Langerhans Cell Histiocytosis
What population is LCH present in?
Young smokers
What does LCH look like histologically?
A stellate lung lesion with eosinophils, langerhans cells, and varying fibrosis and cysts
What can patients with LCH present with?
pneumothorax
What can LCH reverse with?
Smoking cessation
