Sleep Flashcards

1
Q

What is the homeostatic process of normal sleep regulation

A

Dependent on the amount of sleep and wakefulness
• Balance between the need for sleep (sleep pressure) with increasing duration
of wakefulness

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2
Q

What is the circadian process of normal sleep regulation?

A

Dependent on endogenous circadian pacemaker generating near 24-hour
cycles of behavior
• Regulated by the SCN (suprachiasmatic nucleus) in the hypothalamus to
“consolidate” sleep and wakefulness

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3
Q

What are normal changes in sleep in aging?

A
↓ in N3 [women preserve w/aging]
• ↓ in REM
• Sleep efficiency ↓ 80-85%
• Ability to sleep in consolidated longer sleep bout(s) decreases (homeostatic
dysfunction rather than circadian)
• Need for sleep does not decrease
• Daytime sleepiness ↑
• Napping may increase
• An apparent shift is prevalent w/earlier fall asleep and earlier awakening
(melatonin related; SCN aging)
• Difficulty tolerating phase shifts
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4
Q

What should be included in sleep assessment?

A
Any sleep problems?
• Sleep schedule
• Bedtime
• Awakening time
• Consistency
• Naps
• Sleep latency
• Awakenings & reasons
• Sleep partner’s complaints
• Awake schedule
• Daily activities
• Naps
• Refreshed on awakening?
• Sleep at inappropriate times?
• Abnormal behaviors during sleep/naps
• Driving habits
• Number hrs/day driven
• History of fall asleep accidents/near misses
• History of single vehicle accidents
• Occupational driving
• Sleepiness during activities?
• Short-term memory difficulties?
• Mood changes?
• Relationship and sexual activity changes?
• Cognitive changes?
• Caffeine, ETOH, tobacco, illicit drugs
• Exercise, light exposure, meal times
• Evening & late night activities?
• Past medical history
• Pre-existing sleep disturbances
• CV disease
• Neurologic disorders, particularly of vascular
origin
• Family medical history
• Medications
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5
Q

What are clinically-valuable sleep symptom & assessment instruments?

A
  • Epworth Sleepiness Scale
  • Stanford Sleepiness Scale
  • Functional Outcomes of Sleep Questionnaire (copyrighted)
  • Sleep Diary (Consensus Diary – recommended)
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6
Q

OSA tools

A

OSA Screening Tools
• STOP-BANG (Snore, Tired, Observed apnea, high blood Pressure; Bmi, Age,
Neck circumference, Gender)
• Berlin Questionnaire
• OSA Response to Treatment Tools
• Epworth Sleepiness Scale (ESS)
• Functional Outcomes of Sleep Questionnaire (FOSQ

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7
Q

What does STOP BANG stand for?

A

• STOP-BANG (Snore, Tired, Observed apnea, high blood Pressure; Bmi, Age,
Neck circumference, Gender)

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8
Q

What is the diagnosis for chronic insomnia?

A

One or more reported: Difficulty initiating sleep, difficulty maintaining sleep, waking
up earlier than desired, resistance to going to bed on appropriate schedule, difficulty
sleeping without intervention
• One or more related to nighttime difficulty: fatigue/malaise; attention, concentration
or memory impairment; impaired social, family, occupational or academic
performance; mood disturbance/irritability; daytime sleepiness; behavioral
problems; reduced motivation/energy/initiative; proneness for errors/accidents;
concerns about or dissatisfaction with sleep
• Sleep/wake complaints cannot be explained purely by inadequate opportunity or
circumstances for sleep
• Sleep disturbance and associated daytime symptoms occur at least 3X/week
• Sleep disturbance and associated daytime symptoms present for at least 3mo
• Sleep/wake difficulty is not better explained by another sleep disorder

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9
Q

diagnosis for acute insomnia?

A

Report of one or more: difficulty initiating sleep, difficulty maintaining sleep,
waking up earlier than desired, resistance to going to bed on appropriate
schedule, difficulty sleeping without intervention
• Report of one or more related to nighttime sleep difficulty: fatigue/malaise;
attention, concentration or memory impairment; impaired social, family,
vocational or academic performance; mood disturbance/irritability; daytime
sleepiness; behavioral problems; reduced motivation/energy/initiative;
proneness for errors/accidents; concerns about or dissatisfaction with sleep
• Reported sleep/wake complaints not explained purely by inadequate
opportunity or circumstances for sleep
• Disturbance and associated symptoms present for LESS THAN 3 mo
• Sleep/wake difficulty not better explained by another sleep disorder

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10
Q

What does Other Insomnia Disorder entail?

A

• Complain of difficulty initiating and maintaining sleep BUT DO NOT meet full
criteria for either chronic or short-term insomnia
• May be applied when gathering more sleep information
• Use this diagnosis sparingly

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11
Q

What is included in an insomnia assessment guide?

A
Circumstances surrounding onset
• Type of insomnia relative to diagnostic criteria (sleep/wake symptoms)
• Severity, Frequency and Course
• Daytime consequences
• Past Treatments
• Factors that ameliorate
• Factors that exacerbate
• Medical factors
• Pharmacologic considerations (activating drugs, sedating drugs, side effects, history of hypnotic use)
• Psychiatric factors
• Work factors
• Family and social factors
• Comorbid sleep disorders
• Behavioral factors including routines, sleep practices, cognitive factors (i.e., worry)
• Environmental factors
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12
Q

How do you make an insomnia diagnosis?

A

Clinical Assessment
• Sleep Diary records
• ± PSG to r/o other sleep disorder with high clinical suspicion or no treatment
response
• ± Actigraphy to obtain objectively measured sleep/wake patterns

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13
Q

What is sleep restriction therapy? Contraindications?

A

Restrict time in bed as close as possible to actual sleep
time, strengthening the homeostatic sleep drive; sleep “window” is then
gradually increased over days/weeks (contraindicated: seizure, parasomnias like
sleepwalking, bipolar; occupational drivers)

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14
Q

What is stimulus control therapy? Contraindications?

A

Standard set of instructions designed to reinforce the
association between bed and bedroom with sleep and to establish consistent
sleep-wake schedule
• Go to bed only when sleepy
• Get out of bed when unable to sleep (may be contraindicated in older adults d/t falls)
• Use bed/bedroom for sleep only
• Arise at same time every morning
• No napping

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15
Q

What is relaxation therapy?

A

• Relaxation Therapy: Progressive muscle relaxation, meditation; require some
professional guidance at outset and daily practice for weeks-months

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16
Q

What is cognitive therapy?

A

Approach using questioning and behavioral
experiments to reduce excessive worrying about sleep and reframe
faulty beliefs about insomnia and daytime consequences. Trained
interventionist required.

17
Q

What is sleep hygiene education?

A

General guidelines about practices and

environmental factors that promote or interfere with sleep.

18
Q

What is cognitive behavioral therapy?

A

Multimodal intervention combining
some of cognitive and behavioral procedures; selection based on
expert evaluation of insomnia

19
Q

Discuss principles of pharm treatment of insomnia

A

Pharmacological Treatment
• SEE p. 488-9 Evaluation and Management of Chronic Insomnia in Adults
• Contraindicated in pregnancy, OSA, substance abuse disorder, liver disease
• In older adults, consider benefits and risks of using pharmacological
treatment for insomnia
• Side effects
• Drug-drug interactions
• Other comorbidities that heighten risks with pharm tx of insomnia
• ALWAYS monitor treatment response with
• Ongoing sleep diary
• Repeated insomnia and sleep quality measures
• Review person-specific goals for treatment on a regular basis with insomnia
treatment

20
Q

What is OSA? Define based on severity as well.

A
Definition & Type by Severity Repetitive hypopneas (partial
airway collapse) and apneas
(complete airway collapse)
during sleep; results in
intermittent hypoxia and sleep
fragmentation
.
Mild: Apnea Hypopnea Index
(AHI) ≥5
-15 events/hr
Moderate: AHI >15
-30
events/hr
Severe: AHI >30 events/hr
21
Q

Discuss the OSA diagnostic criteria.

A

Obstructive Sleep Apnea, Adult (ICD-10-CM G47.33): Requires (A & B)
or C
A. Presence of one or more:
• Complains of sleepiness, nonrestorative sleep, fatigue or insomnia symptoms
• Wakes with breath holding, gasping or choking
• Observed habitual snoring, breath interruptions, or both during sleep
• Diagnosed with HTN, mood disorder, cognitive dysfunction, CAD, stroke, HF,
AF or T2DM
B. Polysomnography (PSG) or Out of Center Sleep Test (OCST)
• ≥5/hr predominantly obstructive events
C. PSG or OCST
• ≥15/hr predominantly obstructive events

22
Q

What is the pathophysiology of OSA?

A

• Airway narrowing (velopharyngeal space, retropalatal space,
retroglossal space)
• Phasic inspiratory muscle “dullness” during sleep
• Other contributing factors
• anatomically narrow airway
• excess soft tissue
• All of which result in airway partial or complete collapse
• Cortical arousals by EEG
• Protective mechanism
• Fragmentation of sleep

23
Q

What are risk factors for OSA?

A

• Obesity
• >65years
• Male (2-3:1 M:F ratio in community based samples)
• Family history of SDB (2-4 fold increase)
• ETOH exacerbates OSA
• Ethnicity (AA, Mexican Americans, Pacific Islanders, East Asians)
• Disorders of craniofacial abnormalities (e.g., Marfan Syndrome, Down
Syndrome)

24
Q

What is the clinical presentation of OSA?

A

Bed partner most reliable source of information!
• Witnessed snoring, nocturnal snorting, gasping and apneas
• Excessive daytime sleepiness (EDS)
• Fatigue
• Drowsiness as opposed to EDS
• Other Night-time Signs/Symptoms: choking or dyspnea that resolves quickly (as
opposed to PND) in sleep (18-31% c/o), unexplained awakenings and
unrefreshing sleep (older adults), restlessness during sleep, nocturia (28% c/o),
GER, dry mouth (74% c/o)
• Other Daytime Signs/Symptoms: MVA (single), concentration, attention, memory
and/or judgement difficulties (F), personality changes (e.g., aggression, irritability,
anxiety, depression), reduced libido or impotence, morning or nocturnal
headaches (dull, generalized; resolve 1-2hrs after sleep)

25
Q

Discuss screening tools and symptoms evaluation tools for OSA

A

Screening Tools
• Berlin Questionnaire
• Scored as low or high risk based on sum of points within 3 categories; High risk with 2 positive
categories; Low risk with only 1 or no categories scored as positive
• STOP-BANG
• Scored as sum score of 8 YES(1)/NO(0) items; High risk =5-8; Intermediate risk =3-4; Low risk =0-2
• Symptom Evaluation Tools
• Epworth Sleepiness Scale (ESS)
• http://epworthsleepinessscale.com/about-the-ess/
• Sum score of 8 items; >10 suggests excessive daytime sleepiness
• Fatigue Severity Scale
• 7-point Likert Scale; 9 items
• Sum score from 9 item responses
• Score >36 indicates fatigue

26
Q

What is the Home sleep study test monitor for and what does it monitor?

A
"for pts with high likelihood of OSA and no significant comorbidities.
monitors:
-oximetry
-airflow, resp effort
-snoring
-position
-heart rate
**NOT SLEEP
27
Q

OSA treatment options

A

Medical Therapies
• Positive Pressure Therapy
• Oral Appliance
• Surgery (UA)

28
Q

Medical therapy strategies for OSA

A

Weight Loss
• 10% reduction in weight = 50% reduction in AHI
• Position Therapy
• Avoid sleeping supine
• Eliminate ETOH and/or sedative use
• Medication Options
• Oxygen, methylxanthines, progestational agents, SSRIs, mixed serotonin receptor
agonists = NOT EFFICACIOUS OPTIONS
• Wake promoting agents/stimulants are considerations when EDS is present and
consequential
• Amphetamines and methylphenidate (efficacious; s/e, including dependence)
• Modafinil (Provigil) or Armodafinil (Nuvigil) safer wake promoting agents (indirect dopamine
receptor agonists)
• THESE DO NOT TREAT OSA; ONLY OSA-ASSOCIATED EDS
• FDA approved indication: persistent sleepiness ON PAP TREATMENT (and adherent)

29
Q

Discuss PAP therapy

A

Continuous (CPAP), bi-level (inspiratory/expiratory; BPAP), or autoadjusting
(APAP)
• Delivers positive pressure to pneumatically splint upper airway open
• Can add O2 (not indicated in OSA without underlying CVD, HF, COPD,
restrictive pulmonary disease)
• Mask selection important to users
• Heated humidification reduces dry mouth, nasal congestion, excessive
salivation during daytime
• Nasal saline sprays, nasal corticosteroid sprays may be needed
• If using nasal only mask interface, must have patent nasal airway

30
Q

Discuss surgical and laser intervention procedures

A

Most effective in mild-moderate OSA
• F/u polysomnogram 12-15 weeks post-procedure
• May reduce success with CPAP if needed
• BALANCE: Risk-Benefits?

31
Q

Discuss oral appliances

A

Dentist referral
• Recurrent dental f/u to “advance” device
• F/u polysomnogram when final advancement determined by dentist
• Adherence