fibromyalgia Flashcards

1
Q

Define fibromyalgia

A

A chronic health problem that causes diffuse musculoskeletal pain with tenderness to touch or pressure affecting muscles and sometimes joints or even the skin.
It is frequently associated with other symptoms and tends to vary in severity. Stress often worsens the symptoms.

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2
Q

What additional syndromes fall under the umbrella term Amplified Musculoskeletal Pain syndrome? (AMPS)

A
Falls under umbrella term known as Amplified Musculoskeletal Pain syndrome (AMPS)
Fibromyalgia
Complex regional pain syndrome (CRPS)
Myofascial pain syndrome
Neuropathic pain
Psychogenic pain
Reflex neurovascular dystrophy (RND)
Reflex sympathetic dystrophy (RSD)
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3
Q

What are commonly reported symptoms of fibromyalgia?

A

Commonly reported symptoms* include:

Sleep problems (waking up unrefreshed) and severe fatigue
Problems with memory or thinking clearly – “fibro fog”
Depression and/ or anxiety
Migraine or tension headaches
Digestive problems: irritable bowel syndrome (IBS) or gastroesophageal reflux disease (GERD)
Irritable or overactive bladder
Chronic pelvic pain
Temporomandibular (TMJ) complaints which may include jaw pain or clicking
Tinnitus (ringing in the ears)

  • In the absence of another identifiable cause of these symptoms
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4
Q

Describe the different pain sensations and distributions of a person with fibromyalgia.

A

Pain tends to wax and wane, and is often migratory
Patients often complain of feeling achy “all over”
Paresthesia may be present in non-anatomical pattern
Patients may complain of a sensation of weakness but there is no objective weakness on exam (assuming good effort by patient)
Remember that pain is not always the presenting symptom!
 Ask about associated symptoms

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5
Q

What should you see on a PA of a person with fibromyalgia?

A

Multiple tender points
No signs of inflammation (calor, rubor, tumor)
No objective weakness
No signs suggesting structural or systemic disease

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6
Q

What lab testing should be done to evaluate fibromyalgia?

A

CBC w/ differential and CMP
evaluating for evidence of inflammation or organ pathology
ESR (Erythrocyte Sedimentation Rate) and CRP (C-Reactive Protein)
CPK (Creatine Phosphokinase)
TSH (Thyroid Stimulating Hormone)
25(OH)-vit D
Other…

Remember to think about the significance of each test you order!
Do not order an ANA (Anti-Nuclear Antibody) or RF (Rheumatoid Factor) unless you think the patient may have an auto-immune inflammatory condition

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7
Q

What three criteria must be met in order for a person to be diagnosed with fibromyalgia?

A
  1. widespread pain >7
  2. present for at least 3 months
  3. pt does not have disorder that would otherwise explain symptoms
    - may have fatigue, waking unrefreshed, cognitive symptoms
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8
Q

How do you assess tender points?

A
Digital palpation should be performed with an approximate force of 4 kg.  A tender point has to be painful (think distress) at palpation, not just "tender.” 11 Of 18 Tender Points
Occipital
Low Cervical
Trapezius
Supraspinatus
Second Rib
Lateral Epicondyle
Gluteal
Greater Trochanter
Knee
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9
Q

Who is affected by fibromyalgia?

A

2-4 % of population
women > men (7x more likely)
average age onset 30-50 years old
first degree relatives have a higher than expected frequency of fibromyalgia syndrome

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10
Q

Describe the pathogenesis of fibromyalgia

A
Genetically susceptible host exposed to stressor

Aberrant central nervous system functioning
- Enhanced excitability
- Decreased inhibition
 
- Altered sensory processing
- Altered autonomic functioning
- Altered neuroendocrine functioning
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11
Q

Describe hoe generalized sensory processing abnormality manifests in those with fibromyalgia

A

Central pain sensitization rather than a peripheral process
Fibromyalgia patients experience pain at a lower threshold
Sensitivity to noises, bright lights, odors, drugs, chemicals may also exist

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12
Q

Describe the relationship between fibromyalgia and autoimmune disorders

A
There is a high prevalence of fibromyalgia syndrome in patients with underlying chronic painful conditions and autoimmune disease including: 
Systemic lupus erythematosus (SLE)
Rheumatoid arthritis (RA)
Sjogren’s syndrome (a systemic autoimmune disease affecting moisture-secreting glands leading to dryness or “sicca”)
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13
Q

How should a provider approach managing fibromyalgia?

A

Schedule adequate time to explain the diagnosis!

Appreciate that labeling patients can be helpful in most and harmful in others
Try to narrow down and find out what is bothering the patient most
What is the impact of his/her symptoms on their life
What is the patient’s perception of the cause
What are the stressors that exacerbate symptoms
Assist the patient in understanding the goals of therapy
Consider a multidisciplinary approach early

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14
Q

What are three main focuses off fibromyalgia treatment?

A

In addition to the H&P and addressing associated symptoms and underlying “primary” conditions, consider focusing on:
Sleep disturbances
Psychological factors
Importance of physical activity

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15
Q

What are sleep disturbances in fibromyalgia?

A

Fibromyalgia patients experience poor sleep
Sleep studies demonstrate “alpha wave intrusion” into deep delta wave sleep
occurs during NREM (non- rapid eye movement) stage-4 (deep) sleep and causes the patient to awaken or to be aroused into a lighter level of sleep
* not specific to fibromyalgia

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16
Q

What psychological factors are there in fibromyalgia?

A

30-50% current of patients with fibromyalgia have mood disorders
Depression
Anxiety

40-70% lifetime incidence psychiatric co-morbidity

17
Q

What are non-pharm management options for fibromyalgia?

A

1) Referral to Sleep Specialist
2) Referral to Mental Health
Cognitive Behavioral Therapy (CBT)
structured educational program to teach coping skills, gain control over illness
improves outcomes in almost all chronic disease
Techniques include relaxation training, cognitive restructuring, problem solving, goal setting
3) Incorporation of a structured Aerobic Exercise Routine
“Start low and go slow”
may exacerbate symptoms in short run
low impact often most tolerable: aquatic, walk, swim, stationary bike
Trigger point injections
Myofascial release
Acupuncture
Chiropractic manipulation
Meditation

18
Q

What are pharmacological treatment options for fibromyalgia?

A

The U.S. Food and Drug Administration has approved 3 medications for the treatment of fibromyalgia.
duloxetine (Cymbalta) (SNRI)
milnacipran (Savella) (SNRI)
pregabalin (Lyrica) (effects on multiple neurotransmitters)

Other commonly used medications:
amitriptyline (Elavil)
cyclobenzaprine (Flexeril)
gabapentin (Neurontin)

Not helpful for fibromyalgia itself but may be used to treat triggers of fibromyalgia:
NSAIDs, acetaminophen (Tylenol)
sleeping aids

AVOID:
Opioids: may lead to increased pain over time
Steroids (unless indicated for comorbidity)
Remember to set expectations: there is no cure for fibromyalgia